Zobrazeno 1 - 10
of 104
pro vyhledávání: '"M. T. Fleming"'
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Many studies have reported metabolomic analysis of different bio-specimens from Parkinson’s disease (PD) patients. However, inconsistencies in reported metabolite concentration changes make it difficult to draw conclusions as to the role o
Externí odkaz:
https://doaj.org/article/99aa8c8bfcb746ab8d44e4a7599a90a8
Autor:
Alise Zagare, German Preciat, Sarah. L. Nickels, Xi Luo, Anna S. Monzel, Gemma Gomez-Giro, Graham Robertson, Christian Jaeger, Jafar Sharif, Haruhiko Koseki, Nico J. Diederich, Enrico Glaab, Ronan M. T. Fleming, Jens C. Schwamborn
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The vast majority of Parkinson’s disease cases are idiopathic. Unclear etiology and multifactorial nature complicate the comprehension of disease pathogenesis. Identification of early transcriptomic and metabolic alterations consistent acr
Externí odkaz:
https://doaj.org/article/1c777ab6bc7a41ed91833568c4533468
Autor:
Almut Heinken, Dmitry A. Ravcheev, Federico Baldini, Laurent Heirendt, Ronan M. T. Fleming, Ines Thiele
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background The human gut microbiome performs important functions in human health and disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of primary bile acids and their subsequent deconjugation and transforma
Externí odkaz:
https://doaj.org/article/dcf614623d0b44eeaf0e6e3d45e6b03b
Autor:
Nicolas Sompairac, Jennifer Modamio, Emmanuel Barillot, Ronan M. T. Fleming, Andrei Zinovyev, Inna Kuperstein
Publikováno v:
BMC Bioinformatics, Vol 20, Iss S4, Pp 1-14 (2019)
Abstract Background The interplay between metabolic processes and signalling pathways remains poorly understood. Global, detailed and comprehensive reconstructions of human metabolism and signalling pathways exist in the form of molecular maps, but t
Externí odkaz:
https://doaj.org/article/69c337f7518147d289a3e882b455e2ff
Autor:
Andrea Sturchio, Luca Marsili, Joaquin A. Vizcarra, Alok K. Dwivedi, Marcelo A. Kauffman, Andrew P. Duker, Peixin Lu, Michael W. Pauciulo, Benjamin D. Wissel, Emily J. Hill, Benjamin Stecher, Elizabeth G. Keeling, Achala S. Vagal, Lily Wang, David B. Haslam, Matthew J. Robson, Caroline M. Tanner, Daniel W. Hagey, Samir El Andaloussi, Kariem Ezzat, Ronan M. T. Fleming, Long J. Lu, Max A. Little, Alberto J. Espay
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Ongoing biomarker development programs have been designed to identify serologic or imaging signatures of clinico-pathologic entities, assuming distinct biological boundaries between them. Identified putative biomarkers have exhibited large variabilit
Externí odkaz:
https://doaj.org/article/6d424a4d86364f5683f8e545b0af57fb
Publikováno v:
npj Parkinson's Disease, Vol 3, Iss 1, Pp 1-13 (2017)
Abstract A specific set of brainstem nuclei are susceptible to degeneration in Parkinson’s disease. We hypothesise that neuronal vulnerability reflects shared phenotypic characteristics that confer selective vulnerability to degeneration. Neuronal
Externí odkaz:
https://doaj.org/article/660046ffff8a480d94d9d334de4ddb98
Autor:
German A. Preciat Gonzalez, Lemmer R. P. El Assal, Alberto Noronha, Ines Thiele, Hulda S. Haraldsdóttir, Ronan M. T. Fleming
Publikováno v:
Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-15 (2017)
Abstract The mechanism of each chemical reaction in a metabolic network can be represented as a set of atom mappings, each of which relates an atom in a substrate metabolite to an atom of the same element in a product metabolite. Genome-scale metabol
Externí odkaz:
https://doaj.org/article/97b1456dd67b450cb0c7455af3d39027
Autor:
Almut Heinken, Johannes Hertel, Geeta Acharya, Dmitry A. Ravcheev, Malgorzata Nyga, Onyedika Emmanuel Okpala, Marcus Hogan, Stefanía Magnúsdóttir, Filippo Martinelli, Bram Nap, German Preciat, Janaka N. Edirisinghe, Christopher S. Henry, Ronan M. T. Fleming, Ines Thiele
Publikováno v:
Nature Biotechnology.
The human microbiome influences the efficacy and safety of a wide variety of commonly prescribed drugs. Designing precision medicine approaches that incorporate microbial metabolism would require strain- and molecule-resolved, scalable computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fad18818c255c25d6cf5be36628b1e6
https://doi.org/10.1038/s41587-022-01628-0
https://doi.org/10.1038/s41587-022-01628-0
Autor:
K. I. W. Kane, E. Lucumi Moreno, C. M. Lehr, S. Hachi, R. Dannert, R. Sanctuary, C. Wagner, R. M. T. Fleming, J. Baller
Publikováno v:
AIP Advances, Vol 8, Iss 12, Pp 125332-125332-11 (2018)
Hydrogels are increasingly used as a surrogate extracellular matrix in three-dimensional cell culture systems, including microfluidic cell culture. Matrigel is a hydrogel of natural origin widely used in cell culture, particularly in the culture of s
Externí odkaz:
https://doaj.org/article/a2b3cf3394664bf6b5217d3afc89ab1d
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005698 (2017)
The metabolic phenotype of cancer cells is reflected by the metabolites they consume and by the byproducts they release. Here, we use quantitative, extracellular metabolomic data of the NCI-60 panel and a novel computational method to generate 120 co
Externí odkaz:
https://doaj.org/article/fa1b987fe15c4f63b5c4ad46c7bdbee5