NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

Autor: Peter Vandenabeele, Sandrine Marchetti, Jorge Caamano, F. Mair, Jacques Piette, Caroline Remouchamps, Cécile Bénézech, Layla Boutaffala, Mathias Heikenwalder, Mathieu J.M. Bertrand, Florian Reisinger, Jean-Ehrland Ricci, A. Hupalowska, Gitta Maria Seleznik, Marianne K. Janas, M. T. Fernandes, Emmanuel Dejardin, Corinne Ganeff, Burkhard Becher, Percy A. Knolle

Publikováno v: Cell Death Differ. 22, 2020-2033 (2015)
Cell death and differentiation

NF-κB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-κB2 processing into p52, a process defined as the alternative, or non-canonical, NF-κB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eca7c065b0fc4d9e0112acaf23025a
https://doi.org/10.1038/cdd.2015.69

VALUE ANALYSIS: Going into a Further Dimension

Autor: M. T. Fernandes

Publikováno v: Engineering, Technology & Applied Science Research, Vol 5, Iss 2 (2015)
Engineering, Technology & Applied Science Research, Vol 5, Iss 2, Pp 781-789 (2015)

Value Analysis (VA), as it was originally conceived, was defined and applied as a cost cutting tool, in order to make products more competitive. That short scope was early identified as limiting further developments and applications of the concept, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78c06f7ad5e1f01312bb512c137dd18
https://etasr.com/index.php/ETASR/article/view/535

A spontaneous increase in intracellular Ca2+in metaphase II human oocytesin vitrocan be prevented by drugs targeting ATP-sensitive K+channels

Autor: Aleksandar Jovanović, Mandy Gall, Katherine M. Whalley, Oladipo A. Madamidola, Natalia Kozlova, Evelyn Barratt, Sarah Martins da Silva, Alison M. Milne, Albaraa Mojadadi, Goncalo M T Fernandes, Christopher L.R. Barratt, Ellen Drew, Sean G. Brown, Navin Dasai

Publikováno v: Human Reproduction (Oxford, England)

STUDY QUESTION Could drugs targeting ATP-sensitive K(+) (K(ATP)) channels prevent any spontaneous increase in intracellular Ca(2+) that may occur in human metaphase II (MII) oocytes under in vitro conditions? SUMMARY ANSWER Pinacidil, a K(ATP) channe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa573879d79803b93d9ae20a3c6acbe1
https://doi.org/10.1093/humrep/dev300

A comparison of cycle control and effect on well-being of monophasic gestodene-, triphasic gestodene- and monophasic desogestrel-containing oral contraceptives. Gestodene Study Group

Autor: V, Bruni, H, Croxatto, J, De La Cruz, M, Dhont, F, Durlot, M T, Fernandes, R P, Andrade, E, Weisberg, M, Rhoa

Publikováno v: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 14(2)

This was an open-label multicenter study to compare the cycle control and effect on well-being of two oral contraceptives containing gestodene and one containing desogestrel. A total of 2419 healthy womenor = 41 years of age were randomized to receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14eb4e4fa4676892173df1cb91a567b7
https://pubmed.ncbi.nlm.nih.gov/10836195

[Norplant, new method of contraception in Portugal]

Autor: M E, Malheiro, M S, Santos, M T, Fernandes

Publikováno v: Sexualidade e planeamento familiar. (7)

The Norplant contraceptive implant is a long-term, reversible method containing levonorgestrel (LNG) and became available in Portugal as of January 1996. It consists of six silastic capsules, which contain a 36 mg dose of LNG, and when inserted under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a925cdbc9b1ab9ab60821e6f0cb61afd
https://pubmed.ncbi.nlm.nih.gov/12179258