Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi

Autor: Abdelbasset A. Farahat, J. Green, Rubem F. S. Menna-Barreto, M. R. Simões-Silva, Maria de Nazaré Correia Soeiro, Arvind Kumar, A. S. G. Nefertiti, D. W. Boykin, J. S. De Araújo, P. B. Da Silva, M. M. F. Batista, M. T. Bahia, Beatriz Philot Pavão

Publikováno v: Antimicrobial Agents and Chemotherapy. 60:4701-4707

The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz), is unsatisfactory. In this context, we performed the phenotypic in vitro screening of novel mono- and diamidines and drug interaction assays with selected compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8921464f8ff5c12615c1f0b96ee272db
https://doi.org/10.1128/aac.01788-15

Trypanosoma cruzi: Immunoglobulin isotype profiles during the acute phase of canine experimental infection with metacyclic or blood trypomastigotes

Autor: Helen Rodrigues Martins, Olindo Assis Martins-Filho, M. de Lana, Wendel Coura-Vital, Washington Luiz Tafuri, Alexandre Barbosa Reis, Cláudia Martins Carneiro, Rodrigo Correa-Oliveira, M. T. Bahia, Vanja Maria Veloso, Andréa Teixeira-Carvalho

Publikováno v: Experimental Parasitology. 120:269-274

A detailed investigation has been carried out about the serological profiles of groups of dogs experimentally infected with metacyclic (MT) or blood (BT) trypomastigotes of Berenice-78 Trypanosoma cruzi strain. Peripheral blood was collected from inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195c32db5d0f7f254fdbfb505165cc27
https://doi.org/10.1016/j.exppara.2008.08.001

Impairment of Interleukin-17A Expression in Canine Visceral Leishmaniosis is Correlated with Reduced Interferon-γ and Inducible Nitric Oxide Synthase Expression

Autor: M. T. Bahia, Maria Adelaide Do-Valle-Matta, Ivo Santana Caldas, Janeusa Trindade de Souto, Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes, Álvaro Fernando da Silva do Nascimento, Antônia Cláudia Jácome da Câmara, T.D.R. Albuquerque, Lúcia Maria da Cunha Galvão, André Talvani

Publikováno v: Journal of comparative pathology. 153(4)

Dogs are the primary urban reservoir of Leishmania infantum and play a crucial role in the transmission of this parasite to man via sandflies. The spleen and liver are the main target organs of L. infantum infection, but few studies have evaluated th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a1f13521e95fc49be5d68ec926dff9
https://pubmed.ncbi.nlm.nih.gov/26590047

Persistence of PCR-positive tissue in benznidazole-treated mice with negative blood parasitological and serological tests in dual infections with Trypanosoma cruzi stocks from different genotypes

Autor: J. C. O. Valamiel-Silva, L. M. Figueiredo, Danielle Marquete Vitelli-Avelar, Olindo Assis Martins-Filho, Marta de Lana, Helen Rodrigues Martins, Andrea M. Macedo, M. T. Bahia, George Luiz Lins Machado-Coelho, Cláudia Martins Carneiro

Publikováno v: The Journal of antimicrobial chemotherapy. 61(6)

Received 16 November 2007; returned 1 January 2008; revised 28 January 2008; accepted 12 February 2008Objectives: To assess different methodologies to better define an early post-therapeutic cure criterionafter benznidazole treatment in BALB/c mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6c50ddada1507f96058e49e59ea054
https://pubmed.ncbi.nlm.nih.gov/18343804

Quantitative analysis of cardiac lesions in chronic canine chagasic cardiomyopathy

Autor: Ivan Barbosa Machado Sampaio, Raquel do Pilar Machado, Rosângela Aparecida França Cajá, Marta de Lana, Marcelo Vidigal Caliari, M. T. Bahia, Washington Luiz Tafuri, Gustavo Albergaria de Magalhães, Cláudia Martins Carneiro, César Augusto Bueno dos Santos

Publikováno v: Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 No. 5 (2002); 273-278
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 44 Núm. 5 (2002); 273-278
Revista do Instituto de Medicina Tropical de São Paulo; v. 44 n. 5 (2002); 273-278
Revista do Instituto de Medicina Tropical de São Paulo
Instituto de Medicina Tropical (IMT)
instacron:IMT
Repositório Institucional da UFOP
Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
Revista do Instituto de Medicina Tropical de São Paulo, Volume: 44, Issue: 5, Pages: 273-278, Published: OCT 2002
Revista do Instituto de Medicina Tropical de São Paulo, Vol 44, Iss 5, Pp 273-278 (2002)

Lesions observed in chronic chagasic cardiopathy frequently produce electrocardiographic alterations and affect cardiac function. Through a computerized morphometrical analysis we quantified the areas occupied by cardiac muscle, connective and adipos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64ddc42adc272d8a305a4c129353bad
https://www.revistas.usp.br/rimtsp/article/view/30641