Zobrazeno 1 - 10
of 43
pro vyhledávání: '"M. Sulecki"'
Autor:
Joan H. Schiller, Athanassios Argiris, W. Song, Nicholas Choong, R. M. Hansen, Ju-Whei Lee, V. Hugec, Suresh S. Ramalingam, Joel N. Saltzman, James P. Stevenson, Tracey L. Evans, M. Sulecki
Publikováno v:
Annals of Oncology. 28:3037-3043
Background Cixutumumab is a fully human IgG1 monoclonal antibody to the insulin-like growth factor type I receptor that can potentially reverse resistance and enhance the efficacy of chemotherapy. Methods Bevacizumab-eligible patients with stage IV o
Publikováno v:
Chemosphere. 112:34-41
6:2 Fluorotelomer iodide [6:2 FTI, F(CF2)(6)CH2CH2I] is the industrial raw material used to manufacture 6:2 fluorotelomer alcohol [6:2 FTOH, F(CF2)(6)CH2CH2OH] and 6:2 FTOH-based products. During its manufacture and industrial use, workers may be exp
Autor:
R. Radkowski, Hussein Tawbi, Ahmad A. Tarhini, F. Viverette, Liza C. Villaruz, Stergios J. Moschos, John M. Kirkwood, M. Sulecki, Janice Shipe-Spotloe
Publikováno v:
British Journal of Cancer
Background: The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) reverses the O6-methylguanine (O6-meG) lesion induced by dacarbazine. Depletion of MGMT can be achieved using O6-meG pseudosubstrates. Herein, we report the first phase
Autor:
Jinxia Liu, Patrick W. Folsom, Lisa M. Sulecki, Ning Wang, Barry W. Wolstenholme, Robert C. Buck, Cheryl A. Bellin
Publikováno v:
Chemosphere. 80:716-723
The aerobic biodegradation of [1,2-(14)C] 6:2 FTOH [F(CF(2))(6)(14)CH(2)(14)CH(2)OH] in a flow-through soil incubation system is described. Soil samples dosed with [1,2-(14)C] 6:2 FTOH were analyzed by liquid scintillation counting, LC/ARC (liquid ch
Autor:
Jinxia Liu, Robert C. Buck, Lisa M. Sulecki, Patrick W. Folsom, Ning Wang, Cheryl A. Bellin, Bogdan Szostek, Patricia K. Panciroli
Publikováno v:
Chemosphere. 78:437-444
The first studies to explore 6-2 fluorotelomer alcohol [6-2 FTOH, F(CF(2))(6)CH(2)CH(2)OH] aerobic biodegradation are described. Biodegradation yields and metabolite concentrations were determined in mixed bacterial culture (90d) and aerobic soil (18
Publikováno v:
Chemosphere. 75:1089-1096
The biodegradation pathways and metabolite yields of [3-(14)C] 8-2 fluorotelomer alcohol [8-2 FTOH, F(CF(2))(7)(14)CF(2)CH(2)CH(2)OH) in aerobic soils were investigated. Studies were conducted under closed (static) and continuous headspace air flow t
Autor:
Allan Tsung, James J. Lee, J. Wallis Marsh, Herbert J. Zeh, Edward Chu, Summer Drummond, Krishna Patel, Weijing Sun, John P. Morcos, Nathan Bahary, M. Sulecki, James Ohr, Barry C. Lembersky, Daniel P. Normolle, Natalie Streeter, David A. Geller, Anuj K. Patel
Publikováno v:
Journal of Clinical Oncology. 35:4081-4081
4081 Background: Biliary adenocarcinoma/cholangiocarcinoma is a rare but aggressive neoplasm. Most patients present with unresectable or metastatic disease with 5-year survival rate ~5%. No second-line regimen has demonstrated clinical benefit in thi
Publikováno v:
Chemosphere. 87(5)
The polyfluorinated carboxylic acids 5:3 acid (C(5)F(11)CH(2)CH(2)CO(2)H) and 7:3 acid (C(7)F(15)CH(2)CH(2)CO(2)H) are major products from 6:2 FTOH (C(6)F(13)CH(2)CH(2)OH) and 8:2 FTOH (C(8)F(17)CH(2)CH(2)OH) aerobic biotransformation, respectively.
Autor:
Jinxia Liu, Patrick W. Folsom, Lisa M. Sulecki, Stephen H. Korzeniowski, Barry W. Wolstenholme, Robert C. Buck, Ning Wang
Publikováno v:
Chemosphere. 82(6)
The aerobic biotransformation of 6:2 FTS salt [F(CF2)6CH2CH2SO3- K+] was determined in closed bottles for 90d in diluted activated sludge from three waste water treatment plants (WWTPs) to compare its biotransformation potential with that of 6:2 FTOH
Autor:
William Gooding, Terry Evans, Judy Foster, Suresh S. Ramalingam, Chandra P. Belani, M. Sulecki
Publikováno v:
Cancer. 116(5)
BACKGROUND: Patients with extensive stage small cell lung cancer (SCLC) who develop disease progression with standard cisplatin-based therapy are reported to have a poor overall prognosis. Irinotecan and paclitaxel are active as single agents and exh