Zobrazeno 1 - 10
of 498
pro vyhledávání: '"M. Strolin Benedetti"'
Autor:
P. Espie, Rhys Whomsley, Michael Canning, François-Xavier Mathy, M. Strolin Benedetti, P. Jacques
Publikováno v:
Fundamental & Clinical Pharmacology. 22:19-23
Competition for uptake and/or efflux transporters can be responsible for drug interactions. Cetirizine is mainly eliminated unchanged in urine through both glomerular filtration and tubular secretion. The aim of this study was to investigate whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2c1d5fee9ea2cbbae1adccc4c6c0de
https://doi.org/10.1111/j.1472-8206.2007.00543.x
https://doi.org/10.1111/j.1472-8206.2007.00543.x
Autor:
Jean-Marie Nicolas, P Collart, Rhys Whomsley, René Coupez, Eugène Baltes, M. Strolin Benedetti
Publikováno v:
Xenobiotica. 34:281-300
1: The pharmacokinetics and metabolism of 14C-levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog after a single oral dose were investigated. Moreover, the in vitro hydrolysis of levetiracetam to its major carboxylic metabolite b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d813f053982d4c4d597847c97c49b3
https://doi.org/10.1080/0049825042000196749
https://doi.org/10.1080/0049825042000196749
Autor:
Eugène Baltes, M. Strolin Benedetti
Publikováno v:
Fundamental & Clinical Pharmacology. 17:281-299
Key factors undergoing maturational changes accounting for differences in drug metabolism and disposition in the pediatric population compared with adults are reviewed. Gastric and duodenal pH, gastric emptying time, intestinal transit time, bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6660b146468ecd25706c17cf21767956
https://doi.org/10.1046/j.1472-8206.2003.00140.x
https://doi.org/10.1046/j.1472-8206.2003.00140.x
Publikováno v:
Journal of Controlled Release. 49:115-122
In the early stages of product development for novel colonic delivery systems, considerable time can be lost in establishing the likely potential of any given research strategy because of a lack of suitable in vitro or animal models. We therefore rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da9091ffe46794d6a7480cb4ba8f10fd
https://doi.org/10.1016/s0168-3659(97)00062-x
https://doi.org/10.1016/s0168-3659(97)00062-x
Autor:
R. Spinelli, E. Frigerio, D. Sassella, M. Strolin Benedetti, Italo Poggesi, R. Rimoldi, L. Carrà
Publikováno v:
Journal of Antimicrobial Chemotherapy. 40:291-294
The pharmacokinetics of ritipenem acoxil, the oral prodrug of the antibiotic ritipenem, were studied in volunteers after single and repeated dosing (500 mg, three times daily for 10 days). Concentrations of ritipenem and open beta-lactam ring metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f045f925b671e9c9f3d1a3b41f2280
https://doi.org/10.1093/jac/40.2.291
https://doi.org/10.1093/jac/40.2.291
Autor:
C. Pellizzoni, Philippe Dostert, A. Benecchi, G. Brianceschi, Italo Poggesi, E. Frigerio, M. Strolin Benedetti
Publikováno v:
Chirality. 9:303-306
Reboxetine, (RS)-2-[(RS)-alpha-(2-ethoxyphenoxy)benzyl]morpholine methanesulphonate, is a racemic compound and consists of a mixture of the (R,R)- and (S,S)-enantiomers. The pharmacokinetics of reboxetine enantiomers were determined in a crossover st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::867cf1d6d166d74d09ba5b749556a1d8
https://doi.org/10.1002/(sici)1520-636x(1997)9:3<303::aid-chir17>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1997)9:3<303::aid-chir17>3.0.co
Publikováno v:
Inflammation Research. 54:367-369
The predictive efficacy of drugs in humans is frequently estimated from both a high affinity for their receptor as measured in vitro and a long plasmatic half-life. This is grossly misleading since one key parameter is missing: drug concentration at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08c31dfd82599847d5e42fdba4cc3e8
https://doi.org/10.1007/s00011-005-1368-3
https://doi.org/10.1007/s00011-005-1368-3
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:331-340
A procedure for the determination of exemestane, a new aromatase inhibitor, in biological fluids is described in this paper. Exemestane is extracted from human plasma and urine by solid-phase and liquid-liquid extraction, respectively. The test compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2184365dda5d45e50d132069126617e
https://doi.org/10.1016/s0928-0987(96)00171-6
https://doi.org/10.1016/s0928-0987(96)00171-6
Autor:
C. Pellizzoni, Italo Poggesi, N. P. Jørgensen, D. M. F. Edwards, M. Strolin Benedetti, E. Paus
Publikováno v:
Biopharmaceutics & Drug Disposition. 17:623-633
The pharmacokinetics of reboxetine have been investigated in 12 healthy male volunteers after a single 2 mg dose of reboxetine and at steady state, following the last administration of a multiple-dose regimen (2mg twice a day for 5 1/2 d). Reboxetine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84909d71a9b5a8829257112398521902
https://doi.org/10.1002/(sici)1099-081x(199610)17:7<623::aid-bdd978>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199610)17:7<623::aid-bdd978>3.0.co
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 681:185-190
A new sensitive high-performance liquid chromatographic (HPLC) method with fluorescence detection was developed for the determination of 2-phenylethylamine (PEA) in human urine. The analytical procedure involved a simple extraction of the analyte fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a085b4be9e029762f52f30d42f1a5d
https://doi.org/10.1016/0378-4347(95)00521-8
https://doi.org/10.1016/0378-4347(95)00521-8