Zobrazeno 1 - 10 of 32 pro vyhledávání: '"M. Strebelow"'
1
Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes
Autor: A. M. Madec, Dong Luo, M. Strebelow, Michael Schlosser, J. P. Banga, Lisa K. Gilliam, Christiane S. Hampe, I. Rjasanowski, Ralf Wassmuth, Katherine A. Binder
Publikováno v: Diabetologia. 48:922-930
Progression to type 1 diabetes is associated with intramolecular epitope spreading to disease-specific antibody epitopes located in the middle region of glutamic acid decarboxylase 65 (GAD65).The relationship between intramolecular epitope spreading
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d844235021fdbc459f97637f8e444b42
https://doi.org/10.1007/s00125-005-1719-1
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2
Prevalence of Diabetes-Associated Autoantibodies in Schoolchildren: The Karlsburg Type 1 Diabetes Risk Study
Autor: Ralf Wassmuth, Michael Schlosser, Wolfgang Kerner, Manfred Ziegler, I. Rjasanowski, M. Strebelow
Publikováno v: Annals of the New York Academy of Sciences. 1037:114-117
This study attempts to assess the prevalence of diabetes-associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3dd7a14e98283ff4bc0a9d0354346
https://doi.org/10.1196/annals.1337.017
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3
A Monoclonal Antibody-Based Characterization of Autoantibodies against Glutamic Acid Decarboxylase in Adults with Latent Autoimmune Diabetes
Autor: Ziegler B, Michael Schlosser, Manfred Ziegler, Rjasanowski I, M. Strebelow
Publikováno v: Autoimmunity. 28:61-68
Autoantibodies to glutamic acid decarboxylase (GAD) are an important marker of the autoimmune-mediated beta-cell destruction in insulin-dependent (Type I) diabetes. However, these autoantibodies are also found in patients with Stiff-man syndrome (SMS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90b69f7c9d185c6d32424d72f787c42
https://doi.org/10.3109/08916939809003868
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4
Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and Stiff-man syndrome
Autor: Michael Schlosser, W. Northemann, M. Strebelow, Manfred Ziegler, Alvin C. Powers, Ziegler B, P. Augstein, F. Lühder
Publikováno v: Acta Diabetologica. 33:225-231
To study the immune response to glutamic acid decarboxylase (GAD) in insulin-dependent diabetes mellitus, monoclonal GAD antibodies after fusion of splenocytes from a nondiabetes-susceptible BALB/c mouse immunized with human recombinant GAD65 were ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d5a65bf913aa2fd5b04eb6540b1556
https://doi.org/10.1007/bf02048548
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5
In insulin-autoantibody-positive children from the general population, antibody affinity identifies those at high and low risk
Autor: M. Strebelow, Peter Achenbach, Anette-G. Ziegler, H. Kenk, Kerstin Koczwara, I. Rjasanowski, Ralf Wassmuth, Michael Schlosser, Ezio Bonifacio
Publikováno v: Diabetologia. 48(9)
Insulin autoantibodies (IAA) precede and predict the onset of type 1 diabetes, but not all children with IAA develop the disease. In affected families, IAA affinity can identify IAA-positive children who are more likely to progress to diabetes. The p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7473c3a0ec416c8ec6352b9848867b23
https://pubmed.ncbi.nlm.nih.gov/16010521
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6
Multiple and high-titer single autoantibodies in schoolchildren reflecting the genetic predisposition for type 1 diabetes
Autor: M. Strebelow, Ilona Rjasanowski, Manfred Ziegler, Michael Schlosser, Ralf Wassmuth
Publikováno v: Annals of the New York Academy of Sciences. 1005
The study aimed to compare the HLA specificities of AAb-positive healthy schoolchildren with those of patients with type 1 diabetes (T1D). HLA-DRB1 and DQB1 alleles were determined in 178 AAb-positive and 339 AAb-negative schoolchildren aged 6-17 yea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e23ccd34291f298db0ccd8690d4e17
https://pubmed.ncbi.nlm.nih.gov/14679044
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7
Karlsburg Type I diabetes risk study of a general population: frequencies and interactions of the four major Type I diabetes-associated autoantibodies studied in 9419 schoolchildren
Autor: Manfred Ziegler, M. Strebelow, Michael Schlosser, Ziegler B, I. Rjasanowski
Publikováno v: Diabetologia. 42(6)
Aims/hypothesis. The Karlsburg Type I (insulin-dependent) diabetes risk study on schoolchildren aims to evaluate the predictive diagnostic value of diabetes-associated autoantibodies in the general population. Methods. We took capillary serum from 94
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca7bee9beea51d974639f126939bb88
https://pubmed.ncbi.nlm.nih.gov/10382585
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8
A monoclonal antibody based enzyme-linked immunosorbent assay for the determination of GAD65, the smaller isoform of glutamic acid decarboxylase
Autor: J, Hamann, J, Hahmann, M, Strebelow, B, Ziegler, M, Ziegler
Publikováno v: Diabetes research (Edinburgh, Scotland). 26(3)
An enzyme-linked immunosorbent assay for GAD65, the smaller form of glutamic acid decarboxylase and an important autoantigen related to Type 1 diabetes, is described. The competitive binding assay is based on a monoclonal antibody specifically reacti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b4fd0231e31595327a8ce7ea834b07f
https://pubmed.ncbi.nlm.nih.gov/7621617
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