Zobrazeno 1 - 10
of 34
pro vyhledávání: '"M. Standiford"'
Autor:
Benjamin D.S. Clarkson, Ethan M. Grund, Miranda M. Standiford, Kanish Mirchia, Maria S. Westphal, Liz S. Muschler, Charles L. Howe
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessar
Externí odkaz:
https://doaj.org/article/d3e995d405734c7cb2114fe8c13949a4
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocytosis on microglial ac
Externí odkaz:
https://doaj.org/article/51cf6a9e5ba6479ca532c06010660dc7
Publikováno v:
SAMPE 2022.
Publikováno v:
The Journal of Immunology. 202:180.1-180.1
Clonally expanded CD8+ T cells outnumber their CD4+ counterparts in MS lesions yet their role in disease pathogenesis and the relevant target antigen(s) remain unknown. We posited that CNS CD8+ T cells are specific for neuronal antigen and may partic
Publikováno v:
Mechanisms of Development. 111:143-147
Polypyrimidine tract binding protein (PTB) is a member of the hnRNP family of RNA binding proteins (Nucleic Acids Res., 20 (1992) 3671) that functions in a number of processes important for the regulation of mRNA metabolism and gene expression (revie
Publikováno v:
Genetics. 157:259-271
Alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts is precisely regulated to ensure the expression of specific MHC isoforms required for the distinctive contractile activities of physiologically specialized muscles. We hav
Publikováno v:
Genetics. 150:1105-1114
Insertions of transposable elements into the myosin heavy chain (Mhc) locus disrupt the regulation of alternative pre-mRNA splicing for multi-alternative exons in the Mhc2, Mhc3, and Mhc4 mutants in Drosophila. Sequence and expression analyses show t
Publikováno v:
Genetics. 147:725-741
The Drosophila muscle myosin heavy chain (Mhc) gene primary transcript contains five alternatively spliced exon groups (exons 3, 7, 9, 11 and 15), each of which contains two to five mutually exclusive members. Individual muscles typically select a sp
Autor:
Koos Miedema, David M. Standiford, Clara Franzini-Armstrong, Mary Beth Davis, Charles P. Emerson
Publikováno v:
Journal of Molecular Biology. 265:40-55
Myosin rod protein (MRP), a 155 kDa protein encoded by a gene internal to the Drosophila muscle myosin heavy chain (Mhc) gene, contains the MHC rod domain, but has 77 unique N-terminal residues that exactly replace the MHC motor and light chain bindi
Autor:
Dean M. Standiford, Mark Lee
Publikováno v:
Flow Measurement and Instrumentation.
Inter-laboratory comparison testing is fundamental to assuring the accuracy of a laboratory’s stated measurement uncertainty, and a requirement for accreditation to ISO/IEC 17025:2005. Inter-laboratory comparisons using Emerson’s Micro Motion® E