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Publikováno v:
Colorectal Disease. 9:146-150
Objective Over the last 6 years, multidisciplinary teams (MDTs) have been established and play a key role in organizing the delivery of cancer care in the UK. There are no published data on the roles of their co-coordinators. To seek the views of col
Autor:
Ben P. Haynes, G. W. Halbert, M. Brampton, B. Nutley, P. Canney, T. J. Powles, L. A. Gumbrell, J. Haviland, T. R. J. Evans, M. Soukop, Helena M. Earl, Mitch Dowsett, Anthony Howell, D. W. Rea, M. Jarman, I. E. Smith, Roger Grimshaw, R. C. Coombes, S. R. D. Johnston, C. J. Twelves, Robert E. Coleman, A. Jones
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:341-348
Idoxifene is a novel selective oestrogen receptor modulator (SERM) which had greater binding affinity for the oestrogen receptor (ER) and reduced agonist activity compared with tamoxifen in preclinical studies. In a randomized phase II trial in 56 po
Autor:
R. Blackie, N. Raby, Grant Fullarton, A. C. McDonald, G. Pentheroudakis, R. Morrison, M. Soukop, T. R. J. Evans, A. McInnes, James Paul
Publikováno v:
Annals of Oncology. 13:1469-1478
Background: The purpose of this study was to evaluate the dose-limiting toxicity (DLT) and maximum tolerated dose of capecitabine when used in combination with epirubicin and cisplatin (ECC) in patients with oesophageal or gastric adenocarcinoma. Res
Autor:
Malcolm R Ranson, Alan T McGown, Barry W. Hancock, A Robbins, Gordon C Jayson, Gavin Halbert, Fiona H Blackhall, John Radford, M. Soukop
Publikováno v:
British Journal of Cancer
Bryostatin 1 is a naturally occurring macrocyclic lactone with promising antitumour and immunomodulatory function in preclinical and phase I clinical investigations. In this phase II study, 17 patients with progressive non-Hodgkin's lymphoma of indol
Autor:
Thomas R. Jeffry Evans, D A Anthony, P. Wilson, Martin Eatock, M El-Abassi, James Paul, M. Soukop, M Smith
Publikováno v:
British Journal of Cancer. 82:1925-1931
A dose-finding study of raltitrexed (tomudex) with cisplatin and epirubicin in advanced gastro-oesophageal adenocarcinoma
Autor:
N. S. Reed, D. Dunlop, M. Soukop, W. Steward, M. M. Eatock, Eric J Fitzsimmons, S. Anderson, N. P. Lucie, P. Tansey, James Paul
Publikováno v:
Clinical Oncology. 10:107-114
This study was intended to ascertain whether the adjunctive administration of filgrastim (r metHuG-CSF, Amgen) would influence the dose intensity of chemotherapy or the morbidity of myelosuppression in patients receiving MOPP or MOPP/EVAP hybrid chem
Autor:
Allan B. MacLean, CR Lewis, Stan B. Kaye, Derek Cruickshank, S. M. Crawford, J. Kennedy, David E. Parkin, James Paul, Henry C Kitchener, T. K. Sarkar, N. S. Reed, H.K. Gordon, M. Soukop, R. Atkinson, R P Symonds, Jim Cassidy, I. D. Duncan, E M Rankin, J. Davis
Publikováno v:
Journal of Clinical Oncology. 14:2113-2119
PURPOSE In 1992, we reported the first results of a randomized study in ovarian cancer, comprising two doses of cisplatin and indicated a significant difference (P = .0008) in median survival. Four years later, we now describe the results of this tri
Autor:
M. Ossi, A. Freeman, Ronald de Wit, Fausto Roila, Benny Zee, Jaap Verweij, H. G. Meerpohl, C. Bountra, Michele Cronin, M. Soukop, Jean Latreille, Leonard Kaizer, David Osoba, J. Casper, Marion Kiechle, H.-J. Schmoll, Pieter H.M. De Mulder, Linda Lettow, Richard J. Gralla, Paul Ward, Mario Dicato, Adam Stewart, C.J. Gardner, John A. Rudd, Joseph L. Pater, E. Anderson, Cindy Rittenberg, Miguel Martin, U. Cramer-Giraud, Gary R. Morrow, A. du Bois, Paul J. Hesketh, Ian N. Olver, Jeremy D. Gale, C.C. Jordan, Robert J. Naylor, Susan Rosenthal, Werner Vach, David Warr, D.J. Twissell, Gavin J. Kilpatrick, Luigi X. Cubeddu, Mel Peralta
Publikováno v:
Oncology. 53:I-IV
Autor:
J. Kennedy, R. Atkinson, J.A. Davis, Stan B. Kaye, M. Soukop, A.B. MacLean, R.I. Lopez, Jim Cassidy, James Paul, HC Kitchener, W. Fullerton, E. Pyper, I. D. Duncan
Publikováno v:
International Journal of Gynecological Cancer. 6:8-14
Although the results from chemotherapy for advanced ovarian carcinoma have improved over the past 15 years with the introduction of platinum compounds, there are still a large number of patients who will relapse from complete response (clinical or pa