Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics

Autor: Dave Singh, M. Silkey, Brian J. O'Connor, Zuzana Diamant, Patricia N. Sidharta, Brianr R. Leaker, Rob Zuiker, Jasper Dingemanse

Publikováno v: Clinical & Experimental Allergy. 44:1044-1052

SummaryBackground CRTH2 is a G-protein-coupled receptor on T helper2 cells that mediates pro-inflammatory effects of prostaglandin D2 in allergic responses. Objective To investigate the tolerability and pharmacokinetics of setipiprant (ACT-129968), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e8f5ec21752e64afc971c98645a2aa
https://doi.org/10.1111/cea.12357

Scleroderma and related disorders: 223. Long Term Outcome in a Contemporary Systemic Sclerosis Cohort

Autor: S. Nihtyanova, V. Ong, C. Black, C. Denton, P. Lutalo, W. Shattles, H. Jones, R. Nouri, A. Hepburn, M. Chard, N. Horwood, M. Lynn, O. Duke, P. Kiely, L. Zouita, U. Davies, R. Hughes, M. Lloyd, J. Nikitorowicz Buniak, X. Shiwen, D. Abraham, R. Stratton, T. Hugle, P. Schuetz, T. Daikeler, A. Tyndall, M. Matucci-Cerinic, U. A. Walker, J. M. van Laar, J. D. Pauling, V. Flower, N. McHugh, S. Liu, A. Leask, N. Aden, K. Khan, R. Hoyles, S. Bhagat, T. Drummond, C. Goh, R. Busch, F. Hall, P. Meyer, P. Moinzadeh, T. Krieg, M. Hellmich, J. Brinckmann, E. Neumann, U. Mueller-Ladner, A. Kreuter, D. Dumitresco, S. Rosenkranz, N. Hunzelmann, N. Binai, T. Huegle, J. van Laar, S. Sonnylal, A. Tam, J. Norman, B. de Crombrugghe, C. B. Chighizola, P. Luigi Meroni, G. Coghlan, F. Newton, E. C. Derrett-Smith, A. Dooley, R. Baliga, A. Hobbs, R. MacAllister, M. Futema, P. Pantelidis, E. Renzoni, B. E. Schreiber, G. J. Coghlan, A. U. Wells, K. Welsh, C. Fonseca, M. Ponticos, A. Wells, L. Guillevin, B. Schwierin, D. Rosenberg, M. Silkey, S. Parapuram, X. Shi-wen, B. Ahmed Abdi, S. Xu

Publikováno v: Rheumatology. 50:iii129-iii137

Background: We have previously compared outcome in two groups of systemic sclerosis (SSc) patients with disease onset a decade apart and we reported data on 5 year survival and cumulative incidence of organ disease in a contemporary SSc cohort. The p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c29867dffa50678c792af8c925f89c2e
https://doi.org/10.1093/rheumatology/ker033

Evaluation of miglustat as maintenance therapy after enzyme therapy in adults with stable type 1 Gaucher disease: a prospective, open-label non-inferiority study

Autor: Cécile Luzy, Dominick Amato, Carla E. M. Hollak, Timothy M. Cox, Ruben Giorgino, M. Silkey, Robert D. Steiner

Publikováno v: Orphanet Journal of Rare Diseases, Vol 7, Iss 1, p 102 (2012)
Orphanet Journal of Rare Diseases
Orphanet journal of rare diseases, 7(1). BioMed Central

Background Previous studies have provided equivocal data on the use of miglustat as maintenance therapy in Gaucher disease type 1. We report findings from a clinical trial evaluating the effects of miglustat treatment in patients with stable type 1 G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b69e19e6942654e0e4eb80367a1102
https://doi.org/10.1186/1750-1172-7-102

Les patients présentant des ulcères digitaux actifs ont une sclérodermie plus sévère que les patients ayant un antécédent d’ulcères digitaux mais pas d’ulcère actif : résultats du registre « Digital Ulcers Observatory » (DUO)

Autor: Thomas Krieg, M. Matucci Cerinic, Elke Hunsche, B. Schwierin, Christopher P. Denton, Loïc Guillevin, M. Silkey

Publikováno v: La Revue de Médecine Interne. 32:S417

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82c4bfe3b7ee5d35d0cea7d57773e792
https://doi.org/10.1016/j.revmed.2011.10.235

Baseline data from a prospective international disease registry for Niemann-Pick disease type C

Autor: Eugen Mengel, Mercedes Pineda, B. Schwierin, Ed Wraith, Marc C. Patterson, Ruben Giorgino, Frits A. Wijburg, Audrey Muller, Marie T. Vanier, M. Silkey

Publikováno v: Molecular Genetics and Metabolism. 102:S34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dfff2c0dbb8d67adb70d724f73aece1
https://doi.org/10.1016/j.ymgme.2010.11.115