Zobrazeno 1 - 10 of 548 pro vyhledávání: '"M. Siegfried"'
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Data from Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation
Autor: Gutian Xiao, Jill M. Siegfried, Lin-Feng Chen, Laura P. Stabile, Shapei Yan, Liwen Li, Lei Han, Fan Sun, Zhaoxia Qu, Jingjiao Zhou
One of the most fundamental and challenging questions in the cancer field is how immunity in patients with cancer is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identify the transcription factor STAT3 as the cu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a97714ca4d19a632cedde4135b8e6809
https://doi.org/10.1158/2326-6066.c.6548764.v1
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Supplementary Figures 1 through 16 and Supplementary Tables 1 through 3 from Myeloid STAT3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance into Tumor-Promoting Inflammation
Autor: Gutian Xiao, Jill M. Siegfried, Lin-Feng Chen, Laura P. Stabile, Shapei Yan, Liwen Li, Lei Han, Fan Sun, Zhaoxia Qu, Jingjiao Zhou
Supplementary Figure S1. Decreased survival rate of lung cancer patients who are older than 65 and with high STAT3 activation in TAMs Supplementary Figure S2. STAT3 knockout in myeloid cells in STAT3DMye mice Supplementary Figure S3. STAT3 knockout i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc2d1878963f2d16031329c2ecbf044
https://doi.org/10.1158/2326-6066.22538389
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Data from STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non–Small Cell Lung Cancer
Autor: Jill M. Siegfried, Jennifer R. Grandis, Daniel E. Johnson, Adam Kornberg, Mariya Farooqui, Christian Njatcha
Constitutively activated STAT3 plays a critical role in non–small cell lung carcinoma (NSCLC) progression by mediating proliferation and survival. STAT3 activation in normal cells is transient, making it an attractive target for NSCLC therapy. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a442db930bf11518af1470001aa394
https://doi.org/10.1158/1535-7163.c.6538144.v1
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Data from Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor
Autor: Jill M. Siegfried, Abdulaziz A. Almotlak, Mariya Farooqui, Christian Njatcha
The STAT3 pathway is frequently overactive in non–small cell lung cancer (NSCLC), an often fatal disease with known risk factors including tobacco and chemical exposures. Whether STAT3 can be downmodulated to delay or prevent development of lung ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3126f49bf72267200884661c8782bc6d
https://doi.org/10.1158/1940-6207.c.6546970.v1
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