Regulatory T Cells Contribute to Resistance against Lyme Arthritis

Autor: Dean T. Nardelli, Emily M. Siebers, Ronald F. Schell, Elizabeth S. Liedhegner, Michael W. Lawlor

Publikováno v: Infect Immun

The symptoms of Lyme disease are caused by inflammation induced by species of the Borrelia burgdorferisensu lato complex. The various presentations of Lyme disease in the population suggest that differences exist in the intensity and regulation of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489c5588f00e26ce32605733c3a0f188
https://doi.org/10.1128/iai.00160-20

Myostatin Inhibition Using ActRIIB-mFc Does Not Produce Weight Gain or Strength in the Nebulin Conditional KO Mouse

Autor: Samuel Ayres, Lin Yang, Emily M. Siebers, Jennifer Tinklenberg, Margaret Beatka, Michael W. Lawlor, Hui Meng, Henk Granzier, Pippa Simpson, Brittany A Fickau

Mutations in at least 12 genes are responsible for a group of congenital skeletal muscle diseases known as nemaline myopathies (NMs). NMs are associated with a range of clinical symptoms and pathological changes often including the presence of cytopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116353e74dd98cd1e84209d36804d84c
https://europepmc.org/articles/PMC6804412/

Pathological Issues in Dystrophinopathy in the Age of Genetic Therapies

Autor: Emily M. Siebers, Nazima Shahnoor, Michael W. Lawlor, Kristy J. Brown

Publikováno v: Annual review of pathology. 14

Dystrophinopathy is a class of genetic skeletal muscle disease characterized by myofiber degeneration and regeneration due to insufficient levels or functioning of dystrophin. Pathological evaluation for dystrophinopathy includes the identification o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe89de3d4a6a027ee20b513ed559fd6
https://pubmed.ncbi.nlm.nih.gov/30148687

Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgACTA1D286G nemaline myopathy mice

Autor: Zizhao Zhang, Hui Meng, Jane Owens, Jennifer Tinklenberg, Nigel G. Laing, Margaret Beatka, Emily M. Siebers, Carl Morris, Kristen J. Nowak, Jacob A. Ross, Lin Yang, Julien Ochala, Michael W. Lawlor

Publikováno v: Tinklenberg, J, Siebers, E, Beatka, M, Meng, H, Yang, L, Zhang, Z, Ross, A J, Ochala, J B E, Morris, C, Owens, J, Laing, N, Nowak, K & Lawlor, M 2018, ' Myostatin inhibition using mRK35 produces skeletal muscle growth and tubular aggregate formation in wild type and TgA CTA1 D286G nemaline myopathy mice ', Human Molecular Genetics, vol. 27, no. 4, pp. 638–648 . https://doi.org/10.1093/hmg/ddx431

Nemaline myopathy (NM) is a heterogeneous congenital skeletal muscle disease with cytoplasmic rod-like structures (nemaline bodies) in muscle tissue. While weakness in NM is related to contractile abnormalities, myofiber smallness is an additional ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f2c101e5732736384a969b4d3666bc
https://kclpure.kcl.ac.uk/en/publications/b2d09aad-233a-4758-989d-fe87c6089cc7

Effects of ketoconazole or rifampin on the pharmacokinetics of tivozanib hydrochloride, a vascular endothelial growth factor receptor tyrosine kinase inhibitor

Autor: Nicholas M. Siebers, Strahs Andrew, William Slichenmyer, James Miller, Monette M. Cotreau

Publikováno v: Clinical Pharmacology in Drug Development. 4:137-142

The vascular endothelial growth factor (VEGF) pathway is associated with the promotion of endothelial cell proliferation, migration, and survival necessary for angiogenesis. VEGF and its three receptor isoforms are often overexpressed in many human s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2603ba66682825b006423bcfc5ba79b4
https://doi.org/10.1002/cpdd.145