Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Derivation of integration‐free iPSCs from a Klinefelter syndrome patient

Autor: M. Shiohara, T. Shimizu, Hideyuki Kobayashi, Toshihiro Tai, Koichi Nagao, Koichi Nakajima

Publikováno v: Reproductive Medicine and Biology

Purpose Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome abnormality in humans. KS is characterized by gynecomastia, tall stature, small testes, low testosterone levels, learning disabilities, and behavioral problems. KS is also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3812d5bb27e834fe7d69ca64868c6
http://europepmc.org/articles/PMC4686545

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development

Autor: K, Sakashita, K, Koike, T, Kinoshita, M, Shiohara, T, Kamijo, S, Taniguchi, T, Kubota

Publikováno v: Journal of Clinical Investigation. 108:1195-1204

We examined the kenetics of p15 methylation and expression during myeloid development. We treated human cord blood CD34+ cells with either GM-CSF alone or in combination with stem cell factor and followed methylation at this locus using bisulfite gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438264d319e24e44dc955f6ea61d5432
https://doi.org/10.1172/jci200113030

Zobrazit plný text záznamu

Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas

Autor: M Shiohara, Rosella Elisei, James A. Fagin, H P Koeffler

Publikováno v: Cancer. 83:2185-2193

BACKGROUND D-type cyclins, in association with the cyclin-dependent kinases CDK4 and CDK6, promote progression through the G1 phase of the cell cycle. CDK activity is modulated by inhibitors such as p15INK4b and p16INK4a. Loss of function of p15INK4b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5e5e9b28d326ff097ef63d60aae7760
https://doi.org/10.1002/(sici)1097-0142(19981115)83:10<2185::aid-cncr18>3.0.co

Zobrazit plný text záznamu

Vitamin D Receptor: No Evidence for Allele-Specific mRNA Stability in Cells Which Are Heterozygous for the Taq I Restriction Enzyme Polymorphism

Autor: W Verbeek, H P Koeffler, Adrian F. Gombart, M Shiohara, Moray J. Campbell

Publikováno v: Biochemical and Biophysical Research Communications. 238:77-80

Allelic variations of the vitamin D receptor (VDR) gene have been associated with the risk of developing prostate cancer in men and osteoporosis in postmenopausal women. Three RFLP's (TaqI, ApaI, BsmI) define two common haplotypes: BAt and baT. None

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932ae659cc383f12b6bd66de7b307d05
https://doi.org/10.1006/bbrc.1997.7239

Zobrazit plný text záznamu

Id2 expression increases with differentiation of human myeloid cells

Autor: Adrian F. Gombart, A Tobler, M A Israel, M. Shiohara, John D Norton, H P Koeffler, K S Spirin, Akira Ishiguro

Publikováno v: Blood. 87:5225-5231

Id proteins are helix-loop-helix (HLH) transcriptional factors that lack the basic DNA binding domain. The Id proteins have been reported generally to function as inhibitors of cell differentiation, and their gene expression is often downregulated du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4832530802d65619235314af0681233
https://doi.org/10.1182/blood.v87.12.5225.bloodjournal87125225

Zobrazit plný text záznamu

Tumor necrosis factor α: Posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells

Autor: M. Akashi, H P Koeffler, Rong Yang, Adrian F. Gombart, M. Shiohara

Publikováno v: Journal of Cellular Physiology. 166:568-576

The p53 protein directly regulates the expression of the WAF1 (wild-type p53-activated fragment 1) protein which is a cyclin-dependent kinase inhibitor (CDK1). DNA damaging agents such as ionizing or UV radiation, and some chemical agents induce WAF1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0314952e1643186f1ce316326be59d57
https://doi.org/10.1002/(sici)1097-4652(199603)166:3<568::aid-jcp11>3.0.co

Zobrazit plný text záznamu

Expression of Id2 and Id3 mRNA in human lymphocytes

Autor: M Rigolet, Akira Ishiguro, John D. Norton, Andreas Tobler, Toshikazu Shimbo, H. P. Koeffler, M Shiohara, K S Spirin

Publikováno v: Leukemia Research. 19:989-996

Helix-loop-helix (HLH) transcription factors are involved in cellular growth and differentiation. The Id (inhibitor of DNA binding and differentiation) HLH proteins, in a dominantly negative fashion, regulate transcriptional activities of basic HLH p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed53e8817db7191400623d9c199dbc4
https://doi.org/10.1016/0145-2126(95)00084-4

Zobrazit plný text záznamu

Absence of WAF1 mutations in a variety of human malignancies

Autor: B. Vogelstein, M. Wada, Dan-Lin Chen, H P Koeffler, Rong Yang, Wafik S. El-Deiry, T. Nakamaki, Seisho Takeuchi, M. Shiohara

Publikováno v: Blood. 84:3781-3784

A newly cloned gene named wild-type p53-activated fragment 1 (WAF1; also known as p21, Pic-1, Cip-1, or SDI1) is directly regulated by p53 and can itself suppress tumor cell growth in culture. Induction of expression of WAF1 may be an important means

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8f1863e09bb9c7cf2a2d75c4415c39f
https://doi.org/10.1182/blood.v84.11.3781.bloodjournal84113781

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání