Zobrazeno 1 - 10
of 486
pro vyhledávání: '"M. Shaver"'
Autor:
Kaitlyn C. Chapin, Alexander G. Dragnich, Whitney D. Gannon, Abigail K. Martel, Matthew Bacchetta, David B. Erasmus, Ciara M. Shaver, Anil J. Trindade
Publikováno v:
JHLT Open, Vol 4, Iss , Pp 100046- (2024)
Background: Prolonged intubation following lung transplantation is thought to delay recovery, yet a paucity of data exists regarding risk factors and outcomes related to extubation failure. Methods: We performed a single-center, retrospective analysi
Externí odkaz:
https://doaj.org/article/06631d60118943b2b23f98a61a90e469
Autor:
Ciara M. Shaver, Jinyuan Liu, Ke Xu, Gong Yang, Madeline C. Morrison, Alexis Goree, Heather O’Dell, Roman Perri, Matthew Bacchetta, Loren Lipworth, Anil J. Trindade
Publikováno v:
JHLT Open, Vol 3, Iss , Pp 100029- (2024)
Transplantation of lungs from donors with active hepatitis C viremia with early initiation of antiviral therapy has been shown to have similar short- and medium-term outcomes compared to transplantation of lungs from nonviremic donors. Consideration
Externí odkaz:
https://doaj.org/article/c7285fd52c284fd0813523d18391f7b2
Autor:
Anil J. Trindade, MD, Kaitlyn C. Chapin, AGNP-C, CCTC, Jennifer N. Gray, PharmD, Yuka Furuya, MD, MSCI, Amy Mullican, RN, Haley Hoy, ACNP, PhD, Caitlin T. Demarest, MD, PhD, Ivan M. Robbins, MD, Matthew Bacchetta, MD, MBA, David B. Erasmus, MD, Ciara M. Shaver, MD, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 6, p e1487 (2023)
Background. Donor-derived cell-free DNA (dd-cfDNA%) is a biomarker of early acute lung allograft dysfunction (ALAD), with a value of ≥1.0% indicating injury. Whether dd-cfDNA% is a useful biomarker in patients >2 y posttransplant is unknown. Our gr
Externí odkaz:
https://doaj.org/article/711fae669f77454abf6c75532b107e48
Autor:
Anil J. Trindade, MD, Kaitlyn C. Chapin, AGNP, Amy Mullican, RN, Jennifer N. Gray, PharmD, Haley Hoy, AGNP, PhD, Caitlin T. Demarest, MD, PhD, Eric S. Lambright, MD, Katie A. McPherson, MD, Stephanie G. Norfolk, MD, Ivan M. Robbins, MD, Matthew Bacchetta, MD, MBA, David B. Erasmus, MD, Ciara M. Shaver, MD, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 12, p e1411 (2022)
Background. Donor-derived cell-free DNA (dd-cfDNA) is a useful biomarker for the diagnosis of acute allograft injury within the first 1 to 2 y after lung transplant, but its utility for diagnosing chronic lung allograft dysfunction (CLAD) has not yet
Externí odkaz:
https://doaj.org/article/f0292f4e8b434720bba0eed3fe2670f5
Autor:
Anil J. Trindade, MD, Whitney D. Gannon, MS, MSN, John W. Stokes, MD, Eric S. Lambright, MD, Katie A. McPherson, MD, Stephanie G. Norfolk, MD, Ivan M. Robbins, MD, Ciara M. Shaver, MD, PhD, Matthew Bacchetta, MD, MBA
Publikováno v:
Transplantation Direct, Vol 8, Iss 10, p e1371 (2022)
Externí odkaz:
https://doaj.org/article/b8473b33ef7d4668b64675b21b711cc8
Autor:
Lindsay N. Redman-Rivera, Timothy M. Shaver, Hailing Jin, Clayton B. Marshall, Johanna M. Schafer, Quanhu Sheng, Rachel A. Hongo, Kathryn E. Beckermann, Ferrin C. Wheeler, Brian D. Lehmann, Jennifer A. Pietenpol
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Previous studies report that mutant p53 proteins have gain-of-function activities and cause oncogenic phenotypes. Herein, the authors engineered two isogenic epithelial cell lines to express wild-type or missense mutant p53 or be deficient for p53 pr
Externí odkaz:
https://doaj.org/article/10bdca26a8b945f9a336e6d86641208a
Autor:
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)
Abstract Background Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients. Though most studies of AKI in sepsis have focused on
Externí odkaz:
https://doaj.org/article/690ce3393a3d42309b8cc3845e0e80b5
Autor:
Jamie E. Meegan, Padmini Komalavilas, Joyce Cheung‐Flynn, Tsz Wing Yim, Nathan D. Putz, Jordan J. Jesse, Kyle D. Smith, Tatiana N. Sidorova, Han Noo Ri Lee, Toria Tomasek, Ciara M. Shaver, Lorraine B. Ware, Colleen M. Brophy, Julie A. Bastarache
Publikováno v:
Physiological Reports, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Sepsis is a devastating disease with high morbidity and mortality and no specific treatments. The pathophysiology of sepsis involves a hyperinflammatory response and release of damage‐associated molecular patterns (DAMPs), including adenos
Externí odkaz:
https://doaj.org/article/c442a96d140a4867a2a4fce0591bff3d
Autor:
Vivek D. Gandhi, Jacqueline-Yvonne Cephus, Allison E. Norlander, Nowrin U. Chowdhury, Jian Zhang, Zachary J. Ceneviva, Elie Tannous, Vasiliy V. Polosukhin, Nathan D. Putz, Nancy Wickersham, Amrit Singh, Lorraine B. Ware, Julie A. Bastarache, Ciara M. Shaver, Hong Wei Chu, R. Stokes Peebles Jr., Dawn C. Newcomb
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Women have higher prevalence of asthma compared with men. In asthma, allergic airway inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-13 production and eosinophil infiltration. Foxp3+ Tregs suppress an
Externí odkaz:
https://doaj.org/article/61b7abbe00a848c7a388570da40f9c5b
Autor:
Alicia N. Rizzo, Sarah M. Haeger, Kaori Oshima, Yimu Yang, Alison M. Wallbank, Ying Jin, Marie Lettau, Lynda A. McCaig, Nancy E. Wickersham, J. Brennan McNeil, Igor Zakharevich, Sarah A. McMurtry, Christophe J. Langouët-Astrié, Katrina W. Kopf, Dennis R. Voelker, Kirk C. Hansen, Ciara M. Shaver, V. Eric Kerchberger, Ryan A. Peterson, Wolfgang M. Kuebler, Matthias Ochs, Ruud A.W. Veldhuizen, Bradford J. Smith, Lorraine B. Ware, Julie A. Bastarache, Eric P. Schmidt
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a lay
Externí odkaz:
https://doaj.org/article/31aa2a1550884c5a8f8b113a7914671a