Výsledky vyhledávání

Akademický článek

A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents

Autor: Kashif Haider, Mohd Shafeeque, Shaikh Yahya, M. Shahar Yar

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100042- (2022)

Cancer is one of the leading causes of death globally, around 10 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe emergence of drug resista

Externí odkaz: https://doaj.org/article/02200759c7d44c6a831d8b6b3dc9abfd

Zobrazit plný text záznamu

Akademický článek

Recent advances and SAR study of 2-substituted benzothiazole scaffold based potent chemotherapeutic agents

Autor: Kashif Haider, Neelima Shrivastava, Ankita Pathak, Rikeshwer Prasad Dewangan, Shaikh Yahya, M. Shahar Yar

Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100258- (2022)

In recent times cancer has become one of the leading causes of death. Globally around 11 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe e

Externí odkaz: https://doaj.org/article/fcbe7b4fdf584a69b68723bdca9498d8

Zobrazit plný text záznamu

Akademický článek

Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K

Autor: Prasanna A. Yakkala, Samir R. Panda, Syed Shafi, V. G. M. Naidu, M. Shahar Yar, Philemon N. Ubanako, Samson A. Adeyemi, Pradeep Kumar, Yahya E. Choonara, Eugene V. Radchenko, Vladimir A. Palyulin, Ahmed Kamal

Publikováno v: Molecules, Vol 27, Iss 21, p 7642 (2022)

A series of new 1,2,4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by multistep synthesis and evaluated for their cytotoxic activity against various human cancer cell lines. It was observed that they were more susceptible to colon a

Externí odkaz: https://doaj.org/article/a27cf8f603c54ec78deb587de2126734

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Design, in-silico study and biological evaluation of newly synthesized 3-chlorobenzofuran congeners as antitubercular agents

Autor: Mohammad Mustaqeem Abdullah, Nasir A. Siddiqui, Ramzi A. Mothana, Fahd A. Nasr, Adnan J. Al-Rehaily, Omer M. Almarfadi, Shahid Karim, Kashif Haider, Md Rafi Haider, M. Shahar Yar

Publikováno v: Arabian Journal of Chemistry, Vol 14, Iss 4, Pp 103034- (2021)

Benzofuran is a heterocyclic scaffold present in various natural products and possess excellent pharmacological properties including anti-tubercular activity as well. A novel series 26 compound containing 3-chlorobenzofuran derivatives are designed,

Externí odkaz: https://doaj.org/article/b5bb0777d43249bba953052e5dd26d43

Zobrazit plný text záznamu

Akademický článek

Synthesis and antimycobacterial activity of novel heterocycles

Autor: M. ASHRAF ALI, A. AHMAD SIDDIQUI, M. SHAHAR YAR

Publikováno v: Journal of the Serbian Chemical Society, Vol 72, Iss 1, Pp 5-11 (2007)

In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI–CXI). These chalcones were further reacted with hydrazine hydrate in etha

Externí odkaz: https://doaj.org/article/25282268f10d40ae82a1a7b3b44bceb0

Zobrazit plný text záznamu

Akademický článek

Design of targeted dosage form of ofloxacin

Autor: E. MANOGRAN, M. ASHRAF ALI, A. AHAMED SIDDIQUI, M. SHAHAR YAR

Publikováno v: Journal of the Serbian Chemical Society, Vol 71, Iss 12, Pp 1269-1273 (2006)

The targeted pro-drug is a classical pro-drug design often representing a non-specific chemical approach to mask undesirable drug properties, such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targ

Externí odkaz: https://doaj.org/article/a5bd5f543aa3435e865d0a0c93d4a466

Zobrazit plný text záznamu