Zobrazeno 1 - 10
of 43
pro vyhledávání: '"M. Semko"'
Autor:
G. Leslie Burnett, Yu C. Yang, James B. Aggen, Jennifer Pitzen, Micah K. Gliedt, Chris M. Semko, Abby Marquez, James W. Evans, Gang Wang, Walter S. Won, Aidan C. A. Tomlinson, Gert Kiss, Christos Tzitzilonis, Arun P. Thottumkara, James Cregg, Kevin T. Mellem, Jong S. Choi, Julie C. Lee, Yongyuan Zhao, Bianca J. Lee, Justin G. Meyerowitz, John E. Knox, Jingjing Jiang, Zhican Wang, David Wildes, Zhengping Wang, Mallika Singh, Jacqueline A. M. Smith, Adrian L. Gill
Publikováno v:
Journal of Medicinal Chemistry. 66:149-169
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric inhibitors of mTORC1 and orthosteric dual inhibitors of mTORC1 and mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cb750ad287b7aa33c649c1e4fa24c0
https://doi.org/10.1021/acs.jmedchem.2c01658
https://doi.org/10.1021/acs.jmedchem.2c01658
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Iryna Demchenko, Borys Maksymchuk, O. Maliar, L. Vysochan, O. Zharovska, M. Semko, T. Branitska, Iryna Maksymchuk
Publikováno v:
Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports). :20-26
Until now, higher educational institutions trained pedagogical personnel for work in the field of physical education and in the field of sports training, which was implemented in the systems of training of sports reserves and sports of the highest ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a568951791c3a70dfc7ee114029d97f4
https://doi.org/10.31392/npu-nc.series15.2020.2(122).04
https://doi.org/10.31392/npu-nc.series15.2020.2(122).04
Autor:
Lesya Filonenko, T. Branitska, Iryna Maksymchuk, Iryna Demchenko, Borys Maksymchuk, O. Zharovska, M. Semko, M. Yuzyk
Publikováno v:
Scientific Journal of National Pedagogical Dragomanov University. Series 15. Scientific and pedagogical problems of physical culture (physical culture and sports). :63-70
The development of the Ukrainian democratic state requires the creation of a qualitatively new national education system in order to ensure revival of intellectual and spiritual potential of the Ukrainian people. Teacher’s personality formation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af33780db6d5163c2e6ae31b64700f6
https://doi.org/10.31392/npu-nc.series15.2019.1(121)20.12
https://doi.org/10.31392/npu-nc.series15.2019.1(121)20.12
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v:
Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t
https://doi.org/10.1021/jm301741t
Autor:
Chris M. Semko, Danielle L. Aubele, Guriqbal S. Basi, Wes Zmolek, Gary Probst, Matthew N. Mattson, Elizabeth F. Brigham, Erich Goldbach, Karina Wong, William A Wallace, John-Michael Sauer, Hing L. Sham, Lan K. Nguyen, Michael P. Bova, Andrei W. Konradi, Albert W. Garofalo, Susanna S. Hemphill, Darren B. Dressen, Kevin P. Quinn, Minghua Sun, Anh P. Truong, Simeon Bowers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5791-5794
The structure–activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate β-amyloid peptide synthesis via γ-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c797a2f9e3d425d83f37dc2fbd3a6ac
https://doi.org/10.1016/j.bmcl.2011.08.008
https://doi.org/10.1016/j.bmcl.2011.08.008
Autor:
Ashutosh S. Jogalekar, Mellem Kevin, Chris M. Semko, Andreas Buckl, Elena S. Koltun, Jacqueline Smith, Naing Aay, Mallika Singh, Christos Tzitzilonis, Robert J. Nichols, Won Walter, Nidhi Tibrewal, Zhengping Wang, Kasia Mordec, Adrian Liam Gill, Gert Kiss, Abby Marquez, Susan E. Wilson, Mae Saldajeno-Concar, David Wilds
Publikováno v:
Cancer Research. 78:4878-4878
Genetic and pharmacologic evidence has shown that SHP2, a non-receptor protein tyrosine phosphatase (PTP) and scaffold protein encoded by the PTPN11 gene, is a convergent signal transduction node that integrates growth factor signals from multiple re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9799dbbd6e549ae1405a9baa4fbc959
https://doi.org/10.1158/1538-7445.am2018-4878
https://doi.org/10.1158/1538-7445.am2018-4878
Autor:
Adrian Liam Gill, Gert Kiss, Daphne Hsieh, Jacqueline Smith, Robert J. Nichols, Chris M. Semko, Naing Aay, Ashutosh S. Jogalekar, Mellem Kevin, Mae Saldajeno-Concar, David Wildes, Won Walter, Andreas Buckl, Christopher J. Schulze, Carlos Stahlhut, Jason Romero, Christos Tzitzilonis, Elena S. Koltun, Abby Marquez
Publikováno v:
Cancer Research. 78:4877-4877
SHP2 (PTPN11) is a non-receptor protein tyrosine phosphatase and scaffold protein that functions in multiple signal transduction pathways. Genetic and pharmacologic evidence supports a role for SHP2 in driving the proliferation of cancer cells depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ded4958643dc44622b33737ce5fb4d
https://doi.org/10.1158/1538-7445.am2018-4877
https://doi.org/10.1158/1538-7445.am2018-4877
Autor:
Xiaocong M, Ye, Andrei W, Konradi, Jenifer, Smith, Danielle L, Aubele, Albert W, Garofalo, Jennifer, Marugg, Marty L, Neitzel, Chris M, Semko, Hing L, Sham, Minghua, Sun, Anh P, Truong, Jing, Wu, Hongbin, Zhang, Erich, Goldbach, John-Michael, Sauer, Elizabeth F, Brigham, Michael, Bova, Guriqbal S, Basi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3502-3506
Significant improvement in metabolic stability on the pyrazolopiperidine scaffold over the original series were achieved and this stability improvement translated in an improved in vivo efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864d25ea6d9242d49f72de8a339b07d1
https://doi.org/10.1016/j.bmcl.2010.04.148
https://doi.org/10.1016/j.bmcl.2010.04.148