Zobrazeno 1 - 10
of 108
pro vyhledávání: '"M. Seiberling"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 45:307-318
Objective Application-site disorders are well-known adverse events (AEs) associated with subcutaneous (s.c.) injection. With high-dose, high-frequency interferon (IFN)-beta1a (Rebif) these AEs are generally mild but may lead to the discontinuation of
Publikováno v:
British Journal of Clinical Pharmacology. 51:429-435
Aims The aims of this study were to determine the effects of the nonsteroidal, selective aromatase inhibitor, anastrozole, at steady-state concentrations, on the pharmacokinetics and pharmacodynamics of warfarin, and to assess whether or not anastroz
Publikováno v:
The Journal of Clinical Pharmacology. 38:1144-1150
In a retrospective analysis of 13 phase I multiple-dose trials, clinical data from 100 volunteers who received placebo were investigated for differences in routine safety laboratory parameters and vital signs between smokers and nonsmokers. Of the 10
Autor:
Jamie J. Zhao, Haiyung Cheng, Amanda Freeman, Sherry D. Holland, Rita Haesen, Raju D. Amin, Patrick Larson, J. Douglas Rogers, M. Merz, M. Seiberling
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:769-777
A study was conducted to (i) characterize the multiple-dose pharmacokinetics of oral montelukast sodium (MK-0476), 10 mg d-1 in healthy young subjects (N = 12), (ii) evaluate the pharmacokinetics of montelukast in healthy elderly subjects (N = 12), a
Publikováno v:
British journal of clinical pharmacology. 51(5)
The aims of this study were to determine the effects of the nonsteroidal, selective aromatase inhibitor, anastrozole, at steady-state concentrations, on the pharmacokinetics and pharmacodynamics of warfarin, and to assess whether or not anastrozole a
Publikováno v:
Journal of clinical pharmacology. 38(12)
In a retrospective analysis of 13 phase I multiple-dose trials, clinical data from 100 volunteers who received placebo were investigated for differences in routine safety laboratory parameters and vital signs between smokers and nonsmokers. Of the 10
Publikováno v:
Arzneimittel-Forschung. 50(1)
In a three-way-crossover study in 18 healthy male and female subjects aged from 20 to 49 years the influence of a 1% and 3% solution of a standardized composition of Citrus limon, succus, and extract from Cydonia oblonga, fructus (Gencydo) on the int
Publikováno v:
Journal of clinical pharmacology. 37(9)
The present study examined the increase in transaminases, especially in ALT in young healthy males during placebo treatment in phase I multiple dose trials. The primary objective was to investigate whether volunteers showing increasing ALT levels als
Autor:
J J, Zhao, J D, Rogers, S D, Holland, P, Larson, R D, Amin, R, Haesen, A, Freeman, M, Seiberling, M, Merz, H, Cheng
Publikováno v:
Biopharmaceuticsdrug disposition. 18(9)
A study was conducted to (i) characterize the multiple-dose pharmacokinetics of oral montelukast sodium (MK-0476), 10 mg d-1 in healthy young subjects (N = 12), (ii) evaluate the pharmacokinetics of montelukast in healthy elderly subjects (N = 12), a
Publikováno v:
Arzneimittel-Forschung. 47(2)
In a two-way crossover study in 18 young female volunteers aged from 22 to 38 years the relative bioavailability and pharmacokinetics of esterified estrogens were investigated after single administration of a sugar-coated tablet formulation (Femavit