Zobrazeno 1 - 10
of 46
pro vyhledávání: '"M. Scott Bowers"'
Autor:
Gladys Morrison, Marina N. Asiedu, Jessica M. Priebe, Jacqueline Dunning, Nayereh Ghoreishi-Haack, Roger A. Kroes, M. Scott Bowers, Amanda L. Barth, Cassia N. Cearley, Joseph R. Moskal
Publikováno v:
Neurobiology of Pain, Vol 7, Iss , Pp - (2020)
Previous studies have shown that oral administration of the NMDAR modulator NYX-2925 alleviates pain in several animal models of neuropathic pain and this appears to be through mPFC, but not spinal, mediated mechanisms. While much is known about the
Externí odkaz:
https://doaj.org/article/135d2d36d9074a59aaae40a10aba95ab
Publikováno v:
Neurosignals, Vol 22, Iss 2, Pp 65-78 (2014)
The small- and intermediate-conductance Ca2+-activated potassium (SK/IK) channels play important roles in the regulation of excitable cells in both the central nervous and cardiovascular systems. Evidence from animal models has implicated SK/IK chann
Externí odkaz:
https://doaj.org/article/270d2ce0ce7d473e84c14f7b1ca4fcb4
Autor:
Ryan E Feaver, M Scott Bowers, Banumathi K Cole, Steve Hoang, Mark J Lawson, Justin Taylor, Brian D LaMoreaux, Lin Zhao, Brad R Henke, Brian A Johns, Andrew C Nyborg, Brian R Wamhoff, Robert A Figler
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291330 (2023)
Some health concerns are often not identified until late into clinical development of drugs, which can place participants and patients at significant risk. For example, the United States Food and Drug Administration (FDA) labeled the xanthine oxidase
Externí odkaz:
https://doaj.org/article/73653be581c742099685677071b70e9b
Autor:
Srishti U. Sahu, M. Scott Bowers, Luisa P. Cacheaux, Joseph A. Sennello, Katherine Leaderbrand, Mary E. Schmidt, Joseph R. Moskal, M. Amin Khan, Roger A. Kroes
Publikováno v:
Journal of Neurochemistry
N‐methyl‐d‐aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, although selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but N‐methyl‐d‐aspartate receptor subun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b46cab2807da9a4bb10479a5c931ac
http://europepmc.org/articles/PMC7065110
http://europepmc.org/articles/PMC7065110
Autor:
M. Scott Bowers, Jennifer T. Wolstenholme, Sean P. Farris, Andrew D. van der Vaart, Jennifer S Hill, Angela M. Batman, Fazil Aliev, Michael F. Miles, Xianfang Meng, Danielle M. Dick, Thomas A. Green
Publikováno v:
Neuropsychopharmacology. 43:2521-2531
Understanding how ethanol actions on brain signal transduction and gene expression lead to excessive consumption and addiction could identify new treatments for alcohol dependence. We previously identified glycogen synthase kinase 3-beta (Gsk3b) as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263f44f5a761a805cb6e77d12bbf2408
https://doi.org/10.1038/s41386-018-0202-x
https://doi.org/10.1038/s41386-018-0202-x
Autor:
Jessica M. Priebe, M. Amin Khan, Nayereh Ghoreishi-Haack, M. Scott Bowers, Cassia N. Cearley, Jeffrey Burgdorf, Elizabeth M. Colechio, Jacqueline D. Aguado, Joseph R. Moskal
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:485-497
NYX-2925 [(2S,3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide] is a novel N-methyl-d-aspartate (NMDA) receptor modulator that is currently being investigated in phase 2 clinical studies for the treatment of painful di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef67f98d28d9b4ad7cebba9e1a0e4717
https://doi.org/10.1124/jpet.118.249409
https://doi.org/10.1124/jpet.118.249409
Autor:
M. Scott Bowers, Ryan S. Poland, Alexander B Pais, Jennifer T. Wolstenholme, Andrew G. Davies, Jill C. Bettinger, Justin L. Poklis, A. Christian Pais
Publikováno v:
Alcoholism: Clinical and Experimental Research. 42:1476-1485
BACKGROUND: Complex interactions between environmental and genetic factors influence the risk for developing alcohol use disorder (AUD) in humans. To date, studies of the impact of environment on AUD risk have primarily focused on psychological chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83dbb9d737a721205f754e73207292d
https://doi.org/10.1111/acer.13780
https://doi.org/10.1111/acer.13780
Publikováno v:
Drug and Alcohol Dependence. 180:241-259
Background Substance use disorder (SUD) remains a significant public health issue. A greater understanding of how genes and environment interact to regulate phenotypes comprising SUD will facilitate directed treatments and prevention. Methods The lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c1f7b96d7399d2eaa84c75a288cd11
https://doi.org/10.1016/j.drugalcdep.2017.06.040
https://doi.org/10.1016/j.drugalcdep.2017.06.040
Autor:
Marina N. Asiedu, Gladys Morrison, Roger A. Kroes, Nayereh Ghoreishi-Haack, M. Scott Bowers, Cassia N. Cearley, Joseph R. Moskal, Jacqueline Ann Dunning, Jessica M. Priebe, Amanda Lynn Barth
Publikováno v:
Neurobiology of Pain
Neurobiology of Pain, Vol 7, Iss, Pp-(2020)
Neurobiology of Pain, Vol 7, Iss, Pp-(2020)
Highlights • Direct injection of the NMDAR modulator NYX-2925 in the mPFC, reverses allodynia. • Src activity is downregulated in the mPFC of a CCI neuropathic pain model. • NYX-2925 restores pain induced decrease of phosphorylated NMDAR’s.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f2fd57a0bd84aa843cf81d0e350d10
https://pubmed.ncbi.nlm.nih.gov/31909296
https://pubmed.ncbi.nlm.nih.gov/31909296
Publikováno v:
Neuropharmacology. 109:281-292
There are no FDA-approved pharmacotherapies for cocaine use disorder, indicating a need to identify novel reagents with therapeutic potential. Ibudilast is an anti-inflammatory glial attenuator and non-selective phosphodiesterase inhibitor currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e15793f018b18f7e1815f925c97b1b6
https://doi.org/10.1016/j.neuropharm.2016.06.024
https://doi.org/10.1016/j.neuropharm.2016.06.024