MicroRNA-216a is essential for cardiac angiogenesis

Autor: Rio P. Juni, Jordy M.M. Kocken, Ricardo C. Abreu, Lara Ottaviani, Tim Davalan, Burcu Duygu, Ella M. Poels, Aliaksei Vasilevich, Jana C. Hegenbarth, Mahesh Appari, Nicole Bitsch, Serve Olieslagers, Dorien M. Schrijvers, Monika Stoll, Joerg Heineke, Jan de Boer, Leon J. de Windt, Paula A. da Costa Martins

Publikováno v: Juni, R P, Kocken, J M M, Abreu, R C, Ottaviani, L, Davalan, T, Duygu, B, Poels, E M, Vasilevich, A, Hegenbarth, J C, Appari, M, Bitsch, N, Olieslagers, S, Schrijvers, D M, Stoll, M, Heineke, J, de Boer, J, de Windt, L J & da Costa Martins, P A 2023, ' MicroRNA-216a is essential for cardiac angiogenesis ', Molecular Therapy, vol. 31, no. 6, pp. 1807-1828 . https://doi.org/10.1016/j.ymthe.2023.04.007
Molecular Therapy, 31(6), 1807-1828. Nature Publishing Group

While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis in heart failure rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4cdfbed4c34e65e260ef80ffb25f52
https://research.vumc.nl/en/publications/afc667a8-f509-4264-b38a-61a3f329b22d

Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model.

Autor: Miche Rombouts, Nathalie Cools, Mandy O J Grootaert, Flore de Bakker, Ilse Van Brussel, An Wouters, Guido R Y De Meyer, Benedicte Y De Winter, Dorien M Schrijvers

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169608 (2017)

BACKGROUND AND AIMS:Increased evidence suggests a pro-atherogenic role for conventional dendritic cells (cDC). However, due to the lack of an exclusive marker for cDC, their exact contribution to atherosclerosis remains elusive. Recently, a unique tr

Externí odkaz: https://doaj.org/article/4f05fea76aac41449b58a9d7137cd249

Acetylsalicylic Acid Reduces Passive Aortic Wall Stiffness and Cardiovascular Remodelling in a Mouse Model of Advanced Atherosclerosis

Autor: Lynn Roth, Miche Rombouts, Dorien M. Schrijvers, Besa Emini Veseli, Wim Martinet, Guido R. Y. De Meyer

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 404
International Journal of Molecular Sciences, Vol 23, Iss 404, p 404 (2022)
International Journal of Molecular Sciences
International journal of molecular sciences

Acetylsalicylic acid (ASA) is widely used in secondary prevention of cardiovascular (CV) disease, mainly because of its antithrombotic effects. Here, we investigated whether ASA can prevent the progression of vessel wall remodelling, atherosclerosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc10ce48de63f213837f77334e725878

P1.3 A NEW DYNAMIC ORGAN BATH SETUP TO ASSESS ISOBARIC STIFFNESS PARAMETERS OF PERIODICALLY STRETCHED ISOLATED MOUSE AORTIC SEGMENTS

Autor: Arthur J.A. Leloup, Cor E. Van Hove, Guido R.Y. De Meyer, Dorien M. Schrijvers, Gilles W. De Keulenaer, Paul Fransen

Publikováno v: Artery Research, Vol 12 (2015)

Cyclic stretch is a major contributor of vascular function. However, isolated mouse aortas are frequently studied at low stretch frequency or even isometric conditions. Pacing experiments done in rodents and humans show that arterial compliance is hi

Externí odkaz: https://doaj.org/article/f8526286477e4ef08859033819b9f5c1

Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.

Autor: Paul Fransen, Cor E Van Hove, Arthur J A Leloup, Wim Martinet, Guido R Y De Meyer, Katrien Lemmens, Hidde Bult, Dorien M Schrijvers

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121634 (2015)

L-type Ca2+ channel (VGCC) mediated Ca2+ influx in vascular smooth muscle cells (VSMC) contributes to the functional properties of large arteries in arterial stiffening and central blood pressure regulation. How this influx relates to steady-state co

Externí odkaz: https://doaj.org/article/ab883a644be34d4397516909a7064faf