Zobrazeno 1 - 10
of 153
pro vyhledávání: '"M. Schoof"'
Autor:
F. Modemann, L. Ramke, J. Muschhammer, L. Behrmann, V. Thaden, M. Schoof, C. Göbel, S. Neyazi, C. Bokemeyer, J. Wellbrock, U. Schüller, W. Fiedler
Publikováno v:
HemaSphere, Vol 6, Pp 331-332 (2022)
Externí odkaz:
https://doaj.org/article/533f46775789484099a925c532689bc6
Autor:
Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Anne-Katrine Frank, Coline Gentil, Jakob Woessmann, Erwin M. Schoof, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA NT), promoting expression of the leuk
Externí odkaz:
https://doaj.org/article/015f842398434c8ab9d3b64437bd9772
Autor:
Valdemaras Petrosius, Pedro Aragon-Fernandez, Nil Üresin, Gergo Kovacs, Teeradon Phlairaharn, Benjamin Furtwängler, Jeff Op De Beeck, Sarah L. Skovbakke, Steffen Goletz, Simon Francis Thomsen, Ulrich auf dem Keller, Kedar N. Natarajan, Bo T. Porse, Erwin M. Schoof
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state heterogeneity and distinct cellular signaling patterns that remain obscured with population-based techniques. The limited amount of material e
Externí odkaz:
https://doaj.org/article/14054e0093804c9391743fbe1ba55ea0
Autor:
Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla W. Zornhagen, Jan E. Strøbech, Lutz Fleischhauer, Alejandro E. Mayorca-Guiliani, Sebastian R. Nielsen, Dina S. Grønseth, Filip Kuś, Erwin M. Schoof, Luis Arnes, Manuel Koch, Hauke Clausen-Schaumann, Valerio Izzi, Raphael Reuten, Janine T. Erler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as such plays
Externí odkaz:
https://doaj.org/article/1b359b8013e44394a924f6031f8d7cb2
Autor:
Laura Louise Lindqvist, Scott A. Jarmusch, Eva C. Sonnenschein, Mikael Lenz Strube, Janie Kim, Maike Wennekers Nielsen, Paul J. Kempen, Erwin M. Schoof, Sheng-Da Zhang, Lone Gram
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT In the marine environment, surface-associated bacteria often produce an array of antimicrobial secondary metabolites, which have predominantly been perceived as competition molecules. However, they may also affect other hallmarks of surface-
Externí odkaz:
https://doaj.org/article/3d2f46eddfe04f64be71823e7bc0f9f4
Autor:
Klaus Rieneck, Karen Koefoed Rasmussen, Erwin M Schoof, Frederik Banch Clausen, Henrietta Holze, Thomas Bergholt, Marianne Hørby Jørgensen, Vibeke Brix Christensen, Runar Almaas, Peter Lüttge Jordal, Marie Locard-Paulet, Kasper Runager, Leif Kofoed Nielsen, Balthasar Clemens Schlotmann, Joachim Lütken Weischenfeldt, Lars Juhl Jensen, Morten Hanefeld Dziegiel
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0286432 (2023)
The prevailing concept is that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting a currently unknown antigen on the liver of the fetus. This leads to deposition of complement on the fetal hepatocytes and death of
Externí odkaz:
https://doaj.org/article/6c90ac40f7e14cda8962eef73d907e21
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105806- (2023)
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints
Externí odkaz:
https://doaj.org/article/37a3c2b431144addafffad64e750b3d8
Autor:
Valdemaras Petrosius, Erwin M. Schoof
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101556- (2023)
The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-based methods have dominated the field to date, global proteome profiling has also entered the main stage. Single-cell proteomics was facilitated by advancements i
Externí odkaz:
https://doaj.org/article/27cc4e9753ae47f09f09a778521f5dbf
Autor:
Jacek Mikosiński, Konstantinos Kalogeropoulos, Louise Bundgaard, Cathrine Agnete Larsen, Simonas Savickas, Aleksander Moldt Haack, Konrad Pańczak, Katarzyna Rybołowicz, Tomasz Grzela, Michał Olszewski, Piotr Ciszewski, Karina Sitek-Ziółkowska, Krystyna Twardowska-Saucha, Marek Karczewski, Daniel Rabczenko, Agnieszka Segiet, Patrycja Buczak-Kula, Erwin M. Schoof, Sabine A. Eming, Hans Smola, Ulrich auf dem Keller
Publikováno v:
Acta Dermato-Venereologica, Vol 102 (2022)
Venous leg ulcers represent a clinical challenge and impair the quality of life of patients. This study examines impaired wound healing in venous leg ulcers at the molecular level. Protein expression patterns for biomarkers were analysed in venous le
Externí odkaz:
https://doaj.org/article/31658718b32f49b98ef383dab62ffeef
Autor:
Erwin M. Schoof, Benjamin Furtwängler, Nil Üresin, Nicolas Rapin, Simonas Savickas, Coline Gentil, Eric Lechman, Ulrich auf dem Keller, John E. Dick, Bo T. Porse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Single-cell proteomics can provide insights into the molecular basis for cellular heterogeneity. Here, the authors develop a multiplexed single-cell proteomics and computational workflow, and show that their strategy captures the cellular hierarchies
Externí odkaz:
https://doaj.org/article/e6eed179838c43b99f45da74c1d34042