Zobrazeno 1 - 10
of 933
pro vyhledávání: '"M. Schmiedel"'
Autor:
Lukas Junk, Volker M. Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Vill, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V. Krishnamurthy, Shridhar Narayanan, Radha Krishan Shandil, Mayas Singh, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerhard Gmaschitz, Uli Kazmaier, Anton Meinhart, Julia Leodolter, David Hoi, Sabryna Junker, Francesca Ester Morreale, Tim Clausen, Rainer Kalscheuer, Harald Weinstabl, Guido Boehmelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence of new resistance mechanisms. Targeted
Externí odkaz:
https://doaj.org/article/762402cfc91745d09f200167975e5d00
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Deep mutational scanning (DMS) enables multiplexed measurement of the effects of thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a customizable pipeline, DiMSum, that represents an end-to-end solution for o
Externí odkaz:
https://doaj.org/article/00c2de803bfe4d1cb9a45d70315f62d2
Autor:
Benedetta Bolognesi, Andre J. Faure, Mireia Seuma, Jörn M. Schmiedel, Gian Gaetano Tartaglia, Ben Lehner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formati
Externí odkaz:
https://doaj.org/article/0fca2a044c88458bacfb8b409c6af5b7
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Quantifying the effects of noise in gene expression is difficult since noise and mean expression are coupled. Here the authors determine fitness landscapes in mean-noise expression space to uncouple these two parameters and show that changes in noise
Externí odkaz:
https://doaj.org/article/10feb400f6b84630a3dac2896ceecceb
Autor:
David M. Hoi, Sabryna Junker, Lukas Junk, Kristin Schwechel, Katharina Fischel, David Podlesainski, Paige M.E. Hawkins, Lasse van Geelen, Farnusch Kaschani, Julia Leodolter, Francesca Ester Morreale, Stefan Kleine, Somraj Guha, Klaus Rumpel, Volker M. Schmiedel, Harald Weinstabl, Anton Meinhart, Richard J. Payne, Markus Kaiser, Markus Hartl, Guido Boehmelt, Uli Kazmaier, Rainer Kalscheuer, Tim Clausen
Publikováno v:
Cell. 186:2176-2192.e22
The ClpC1:ClpP1P2 protease is a core component of the proteostasis system in mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease, we characterized the mechanism of the antibiotics cyclomarin A and ecumicin. Quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4481cf8ebafba582647015548944c2d4
https://doi.org/10.1016/j.cell.2023.04.009
https://doi.org/10.1016/j.cell.2023.04.009
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2564-2569 (2013)
Herein we present the synthesis of the anhydrophytosphingosine jaspine B and three of its stereoisomers using a carbohydrate-derived alkoxyallene in order to obtain the products in enantiopure form. Key step of the reaction sequence is the addition o
Externí odkaz:
https://doaj.org/article/eab829edb2694e7dac41f52f07e3a8ec
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Genome Biology
Genome Biology
Deep mutational scanning (DMS) enables multiplexed measurement of the effects of thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a customizable pipeline, DiMSum, that represents an end-to-end solution for obtaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f75735282e1164ff3e37e174f340596
http://link.springer.com/article/10.1186/s13059-020-02091-3
http://link.springer.com/article/10.1186/s13059-020-02091-3
Autor:
Andre J. Faure, Júlia Domingo, Jörn M. Schmiedel, Cristina Hidalgo-Carcedo, Guillaume Diss, Ben Lehner
Allosteric communication between distant sites in proteins is central to biological regulation but still poorly characterized, limiting understanding, engineering and drug development1-6. An important reason for this is the lack of methods to compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c3827adbe93c3a6947eb2b5845d561
http://hdl.handle.net/10230/53077
http://hdl.handle.net/10230/53077
Autor:
Guillaume Diss, Jörn M. Schmiedel, Júlia Domingo, Ben Lehner, Andre J. Faure, Cristina Hidalgo-Carcedo
Allosteric communication between distant sites in proteins is central to nearly all biological regulation but still poorly characterised for most proteins, limiting conceptual understanding, biological engineering and allosteric drug development. Typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19cf3753fde33d31fa03a4c5af419f78
https://doi.org/10.1101/2021.09.14.460249
https://doi.org/10.1101/2021.09.14.460249
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications
The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean expression and noise we deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed12f6696c667c9fe10b681f95e793d
http://link.springer.com/article/10.1038/s41467-019-11116-w
http://link.springer.com/article/10.1038/s41467-019-11116-w