Zobrazeno 1 - 10
of 224
pro vyhledávání: '"M. Schewe"'
Publikováno v:
Journal of Sensors and Sensor Systems, Vol 13, Pp 167-177 (2024)
A method is presented by which very small, slow, anharmonic signals can be extracted from measurement data overlaid with noise that is orders of magnitude larger than the signal of interest. To this end, a multi-step filtering process is applied to a
Externí odkaz:
https://doaj.org/article/6b5573f15832472abb4deaf0a731f21c
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Digitization of phase-modulated carrier signals with a commercially available analog-to-digital converter (ADC) is a common task in many communication and sensor applications. ADCs deliver phase-modulated digital carrier signals, which are n
Externí odkaz:
https://doaj.org/article/b7c09fa1443b48459d22260857d04e48
Autor:
Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt-Supprian, Vera Binder, Irmela Jeremias
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify indiv
Externí odkaz:
https://doaj.org/article/6e797a213a574904a9cff02ded829844
Autor:
Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig, Thies Rösner, Katja Klausz, Christian Kellner, Miriam Bultmann, Lorenz Bastian, Fotini Vogiatzi, Jeanette H. W. Leusen, Renate Burger, Denis M. Schewe, Matthias Peipp, Thomas Valerius
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibody-based immunotherapy is increasingly employed to treat acute lymphoblastic leukemia (ALL) patients. Many T-ALL cells express CD38 on their surface, which can be targeted by the CD38 antibody daratumumab (DARA), approved for the treatment of m
Externí odkaz:
https://doaj.org/article/aae84b3dbc6245b599a09797f9b180bc
Autor:
Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Ahmad Mayar, Anna Dietterle, Gina Münch, Christian Vokuhl, Julia Richter, Andrew G. Polson, Thomas Schüler, Ulf D. Kahlert, Matthias Peipp, Thomas Valerius, Martin Schrappe, Gunnar Cario, Hassan Jumaa, Elias Hobeika, Monika Brüggemann, Ameera Alsadeq, Denis M. Schewe
Publikováno v:
HemaSphere, Vol 6, Iss 8, p e754 (2022)
Externí odkaz:
https://doaj.org/article/ee2a0191775641108c609751c3210508
Autor:
Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq, Denis M. Schewe
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment
Externí odkaz:
https://doaj.org/article/45d481a21f3e44e49b4f84076c7e9181
Autor:
Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,
Externí odkaz:
https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
Autor:
Ž. Antić, P. Chouvarine, J. Lentes, C. Schröder, J. Alten, A. Möricke, M. Brüggemann, E. Carrillo-de Santa Pau, T. Illig, T. Laguna, D. M. Schewe, M. Stanulla, M. Tang, M. Zimmermann, M. Schrappe, B. Schlegelberger, G. Cario, A. K. Bergmann
Publikováno v:
HemaSphere, Vol 6, Pp 206-207 (2022)
Externí odkaz:
https://doaj.org/article/b5728b249bb141ac92747ae418d8d243
Autor:
Martin Stanulla, Denis M. Schewe, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert, Wolfgang Eberl, Saskia Wolf, Julian Wolf, Fotini Vogiatzi, Anke K. Bergmann, Gunnar Cario, Rita Beier, Martin Sauer, Christian P. Kratz, Britta Maecker-Kolhoff
Publikováno v:
Annals of Hematology. 102:669-672
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d6130bb4364d32e6865047812cb0b8
https://doi.org/10.1007/s00277-023-05083-y
https://doi.org/10.1007/s00277-023-05083-y
Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc1d67bb85567d28d48decb91162f8
https://doi.org/10.1182/blood.2021015036
https://doi.org/10.1182/blood.2021015036