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Akademický článek

Extraction of nanometer-scale displacements from noisy signals at frequencies down to 1 mHz obtained by differential laser Doppler vibrometry

Autor: D. Kohlmann, M. Schewe, H. Wulfmeier, C. Rembe, H. Fritze

Publikováno v: Journal of Sensors and Sensor Systems, Vol 13, Pp 167-177 (2024)

A method is presented by which very small, slow, anharmonic signals can be extracted from measurement data overlaid with noise that is orders of magnitude larger than the signal of interest. To this end, a multi-step filtering process is applied to a

Externí odkaz: https://doaj.org/article/6b5573f15832472abb4deaf0a731f21c

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Akademický článek

Improved demodulated phase signal resolution for carrier signals with small modulation index by clipping and synchronous sampling for heterodyne interferometers

Autor: M. Yu, M. Schewe, G. Bauer, C. Rembe

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)

Abstract Digitization of phase-modulated carrier signals with a commercially available analog-to-digital converter (ADC) is a common task in many communication and sensor applications. ADCs deliver phase-modulated digital carrier signals, which are n

Externí odkaz: https://doaj.org/article/b7c09fa1443b48459d22260857d04e48

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Akademický článek

Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by ‘Don´t Eat Me!’ signals such as CD47 expressed by cancer cells. Yet, human leukocyte antigen (HLA) class

Externí odkaz: https://doaj.org/article/741297763a5b405c9c2232db5b220176

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Akademický článek

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify indiv

Externí odkaz: https://doaj.org/article/6e797a213a574904a9cff02ded829844

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Akademický článek

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab

Autor: Niklas Baumann, Christian Arndt, Judith Petersen, Marta Lustig, Thies Rösner, Katja Klausz, Christian Kellner, Miriam Bultmann, Lorenz Bastian, Fotini Vogiatzi, Jeanette H. W. Leusen, Renate Burger, Denis M. Schewe, Matthias Peipp, Thomas Valerius

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Antibody-based immunotherapy is increasingly employed to treat acute lymphoblastic leukemia (ALL) patients. Many T-ALL cells express CD38 on their surface, which can be targeted by the CD38 antibody daratumumab (DARA), approved for the treatment of m

Externí odkaz: https://doaj.org/article/aae84b3dbc6245b599a09797f9b180bc

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Akademický článek

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)

Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment

Externí odkaz: https://doaj.org/article/45d481a21f3e44e49b4f84076c7e9181

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Akademický článek

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism,

Externí odkaz: https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9

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