Zobrazeno 1 - 10
of 59
pro vyhledávání: '"M. Schaus"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0192974 (2018)
The ability to rapidly assess the preferred conformation of key fragments in a structure "by visual inspection" is a very useful starting point in the process of drug design. With the ability to do so, one could address questions like: "How could we
Externí odkaz:
https://doaj.org/article/3058a2d0d9ac43dc88a0fd3cea11cd14
Autor:
Junliang, Hao, James P, Beck, John M, Schaus, Joseph H, Krushinski, Qi, Chen, Christopher D, Beadle, Paloma, Vidal, Matthew R, Reinhard, Bruce A, Dressman, Steven M, Massey, Serge L, Boulet, Michael P, Cohen, Brian M, Watson, David, Tupper, Kevin M, Gardinier, Jason, Myers, Anette M, Johansson, Jeffery, Richardson, Daniel S, Richards, Erik J, Hembre, David M, Remick, David A, Coates, Rajni M, Bhardwaj, Benjamin A, Diseroad, David, Bender, Greg, Stephenson, Craig D, Wolfangel, Nuria, Diaz, Brian G, Getman, Xu-Shan, Wang, Beverly A, Heinz, Jeff W, Cramer, Xin, Zhou, Deanna L, Maren, Julie F, Falcone, Rebecca A, Wright, Stephen N, Mitchell, Guy, Carter, Charles R, Yang, Robert F, Bruns, Kjell A, Svensson
Publikováno v:
Journal of medicinal chemistry. 62(19)
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38771cd6f379be26a1a0dc76826df19b
https://pubmed.ncbi.nlm.nih.gov/31532644
https://pubmed.ncbi.nlm.nih.gov/31532644
Autor:
Amy K. Chesterfield, Christian C. Felder, Sean R. Donohue, Lee A. Phebus, Joseph Herman Junio Krushinski, Christer Halldin, Victor W. Pike, Eyassu Chernet, John M. Schaus
Publikováno v:
Journal of Medicinal Chemistry. 51:5833-5842
We have reported that [methyl-11C] (3R,5R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)pyrrolidin-2-one ([11C]8, [11C]MePPEP) binds with high selectivity to cannabinoid type-1 (CB1) receptors in monkey brain in vivo. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd164aebbb1e955655411da4d605d20
https://doi.org/10.1021/jm800416m
https://doi.org/10.1021/jm800416m
Autor:
Deyi, Zhang, Maria-Jesus, Blanco, Bai-Ping, Ying, Daniel, Kohlman, Sidney X, Liang, Frantz, Victor, Qi, Chen, Joseph, Krushinski, Sandra A, Filla, Kevin J, Hudziak, Brian M, Mathes, Michael P, Cohen, DeAnna, Zacherl, David L G, Nelson, David B, Wainscott, Suzanne E, Nutter, Wendy H, Gough, John M, Schaus, Yao-Chang, Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(19)
Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::143e37bcd53bad4bd106dfa8f1aa2e9b
https://pubmed.ncbi.nlm.nih.gov/26271587
https://pubmed.ncbi.nlm.nih.gov/26271587
Autor:
Scott K. Sakaluk, Jennifer M. Schaus
Publikováno v:
Canadian Journal of Zoology. 80:582-585
Although studies of various taxa have shown that males can alter the number of sperm in their ejaculates according to the risk of sperm competition, few studies have examined the extent to which the number of sperm transferred by males across multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e545064e6b2211a9f0235d7bcaeb79c
https://doi.org/10.1139/z02-012
https://doi.org/10.1139/z02-012
Autor:
Scott K. Sakaluk, Jennifer M. Schaus
Publikováno v:
Behavioral Ecology. 12:740-745
Costs incurred in the manufacture of ejaculates may constrain the number of sperm that males can produce, so males should show some economy in their allocation of sperm across multiple matings. In species in which females mate with multiple males and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2fdc864661f94be24600e4c61507646
https://doi.org/10.1093/beheco/12.6.740
https://doi.org/10.1093/beheco/12.6.740
Publikováno v:
The UW National Parks Service Research Station Annual Reports. 21:60-63
The sagebrush cricket, Cyphoderris strepitans, is one of only five extant species belonging to an obscure orthopteran lineage, the Haglidae, closely related to the true crickets (Gryllidae) and katydids (Tettigoniidae) (Morris & Gwynne 1978). C. stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ddb027fee0474c9d61b7f56645dfaa9
https://doi.org/10.13001/uwnpsrc.1997.3327
https://doi.org/10.13001/uwnpsrc.1997.3327
Publikováno v:
Materialwissenschaft und Werkstofftechnik. 25:415-419
Die Funktion und der Wirkungsgrad technischer Anlagen wird begrenzt durch die Reaktion eingesetzter Werkstoffe auf die Betriebsbedingungen. Im Hochtemperatureinsatz sind Korrosionsbestandigkeit, Verschleisfestigkeit und Thermoschockfestigkeit ebenso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c07817552b9aa302938de2781135b5
https://doi.org/10.1002/mawe.19940251007
https://doi.org/10.1002/mawe.19940251007
Autor:
Todd M, Suter, Amy K, Chesterfield, Chun, Bao, John M, Schaus, Joseph H, Krushinski, Michael A, Statnick, Christian C, Felder
Publikováno v:
European journal of pharmacology. 649(1-3)
MePPEP ((3R,5R)-5-(3-methoxy-phenyl)-3-((R)-1-phenyl-ethylamino)-1-(4-trifluoromethyl-phenyl)-pyrrolidin-2-one) is an inverse agonist shown to be an effective PET ligand for labeling cannabinoid CB₁ receptors in vivo. [¹¹C]MePPEP and structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df06c64ad0b2cf28f818ef2bb65612d2
https://pubmed.ncbi.nlm.nih.gov/20851117
https://pubmed.ncbi.nlm.nih.gov/20851117
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