Zobrazeno 1 - 10
of 58
pro vyhledávání: '"M. Schach von Wittenau"'
Autor:
M. Schach Von Wittenau
Publikováno v:
Regulatory Toxicology and Pharmacology. 7:113-119
The long-term bioassay for carcinogenic potential is a valuable tool for assessing human hazard, but suffers from severe limitations. Some of these follow directly from the use of animals as surrogates for man; others are created by study design and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094f7efa4b62d9804fd1526d58c025fb
https://doi.org/10.1016/0273-2300(87)90051-1
https://doi.org/10.1016/0273-2300(87)90051-1
Autor:
W. Gordon Walker, Thomas M. Twomey, Andrew Whelton, M. Schach von Wittenau, Joseph R. Bianchine
Publikováno v:
Kidney International. 5(5):365-371
Doxycycline pharmacokinetics in the absence of renal function. Doxycycline is a new tetracycline that is now in widespread clinical use. It differs from the other tetracycline drugs in many important respects including small daily dosage schedules, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4174f2378aa7ff48329730dcb268b658
Publikováno v:
Xenobiotica. 7:357-364
1. [2-14C]Prazosin is rapidly distributed into tissues of the dog including heart, lung and vascular tissues. 2. Urinary excretion by rats and dogs is low, biliary secretion being the major route of elimination. 3. Biotransformation of prazosin in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba494f557eea2e672605df73f7891d18
https://doi.org/10.3109/00498257709035794
https://doi.org/10.3109/00498257709035794
Publikováno v:
Journal of the American Chemical Society. 82:5934-5937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d63056a7c8feac206a19cd553e7f5988
https://doi.org/10.1021/ja01507a034
https://doi.org/10.1021/ja01507a034
Autor:
M. Schach von Wittenau, T.F. Brewer
Publikováno v:
Pharmacology. 6:173-185
Piquizil, a 4-aminoquinazoline causing relaxation of respiratory smooth muscle in animals, appeared to be a bronchodilator in man. A metabolite of piquizil was isolated from human urine and identified. This metabolite, named hoquizil, had a longer pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1efc5a49eceebdb5a679b8ff3736c12c
https://doi.org/10.1159/000136240
https://doi.org/10.1159/000136240
Autor:
M. Schach von Wittenau, T. M. Twomey
Publikováno v:
Chemotherapy. 16:217-228
The disposition of doxycycline by man and dog was investigated with the aid of labeled drug. Isotope dilution methods were instrumental in the successful identification of fecal excretion products. More than 90% of dose was recovered as undegraded dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e065453d3e37789a0922f22f9e2b1f
https://doi.org/10.1159/000220730
https://doi.org/10.1159/000220730
Publikováno v:
Tetrahedron Letters. 1:14-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1a376af20e4cb4b85f431dc1b8019af
https://doi.org/10.1016/s0040-4039(01)99422-5
https://doi.org/10.1016/s0040-4039(01)99422-5
Publikováno v:
Journal of the American Chemical Society. 81:1968-1980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1abe637eeab0c007e2a3fe6a23c622b
https://doi.org/10.1021/ja01517a047
https://doi.org/10.1021/ja01517a047
Autor:
M. Schach von Wittenau
Publikováno v:
Chemotherapy. 13:41-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d262a98a515562d6fbfd9539b16c099b
https://doi.org/10.1159/000220581
https://doi.org/10.1159/000220581
Publikováno v:
The Journal of Organic Chemistry. 30:1231-1234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36e45094f5f6195bfc78531784b96b4
https://doi.org/10.1021/jo01015a065
https://doi.org/10.1021/jo01015a065