CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression

Autor: Martin Franke, Elisa De la Calle-Mustienes, Ana Neto, María Almuedo-Castillo, Ibai Irastorza-Azcarate, Rafael D. Acemel, Juan J. Tena, José M. Santos-Pereira, José L. Gómez-Skarmeta

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

CTCF is as an architectural protein involved in 3D genome folding; however its contribution to animal development has not been well characterized. Here the authors show that CTCF is not only pivotal for 3D chromatin structure and enhancer-promoter in

Externí odkaz: https://doaj.org/article/df452f901a8b424b89ef96928d45625f

Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification

Autor: José M. Santos-Pereira, Lourdes Gallardo-Fuentes, Ana Neto, Rafael D. Acemel, Juan J. Tena

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

The transcription factor p63 is a master regulator of ectoderm development. Here the authors show that zebrafish p63 binds enhancers associated with neural genes to limit Sox3 binding and gene expression while also acting as a pioneer factor by promo

Externí odkaz: https://doaj.org/article/58356b9f31a8417baac5d84a98baac31

Genome-Wide Mapping of Histone H3 Lysine 4 Trimethylation (H3K4me3) and Its Involvement in Fatty Acid Biosynthesis in Sunflower Developing Seeds

Autor: Antonio J. Moreno-Pérez, José M. Santos-Pereira, Raquel Martins-Noguerol, Cristina DeAndrés-Gil, M. Adrián Troncoso-Ponce, Mónica Venegas-Calerón, Rosario Sánchez, Rafael Garcés, Joaquín J. Salas, Juan J. Tena, Enrique Martínez-Force

Publikováno v: Plants, Vol 10, Iss 4, p 706 (2021)

Histone modifications are of paramount importance during plant development. Investigating chromatin remodeling in developing oilseeds sheds light on the molecular mechanisms controlling fatty acid metabolism and facilitates the identification of new

Externí odkaz: https://doaj.org/article/00ea13bf8a4a4290a0e488252302dc68

Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.

Autor: Sandra Gavaldá, José M Santos-Pereira, María L García-Rubio, Rosa Luna, Andrés Aguilera

Publikováno v: PLoS Genetics, Vol 12, Iss 4, p e1005966 (2016)

Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed impairs mRNA export and cell growth. To investigate further the relevance of proper Yra1 stoichiometry in the cell, we ove

Externí odkaz: https://doaj.org/article/c205675b42a1431dac4e7d75841168a4

The Nup84 complex coordinates the DNA damage response to warrant genome integrity

Autor: Hélène Gaillard, Andrés Aguilera, José M. Santos-Pereira

Publikováno v: Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to warrant genome integrity. Beyond their primary role in molecule transport, nuclear pore complexes (NPCs) function in other proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c18e721528c88ff2f5e5db3cf5e2eb
https://doi.org/10.1093/nar/gkz066