Zobrazeno 1 - 10
of 378
pro vyhledávání: '"M. SOUTHERN"'
Autor:
A.T. Pettersson-Klein, M. Izadi, D.M.S. Ferreira, I. Cervenka, J.C. Correia, V. Martinez-Redondo, M. Southern, M. Cameron, T. Kamenecka, L.Z. Agudelo, M. Porsmyr-Palmertz, U. Martens, B. Lundgren, M. Otrocka, A. Jenmalm-Jensen, P.R. Griffin, J.L. Ruas
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 28-42 (2018)
Objective: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic me
Externí odkaz:
https://doaj.org/article/469ce0c9cf6946c19bed00689a2af9b7
Autor:
Lauren J. Sundby, William M. Southern, Jiao Sun, Xiaobai Patrinostro, Wei Zhang, Jeongsik Yong, James M. Ervasti
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151397- (2024)
The cytoplasmic actin proteins, β- and γ-actin, are 99% identical but thought to perform non-redundant functions. The nucleotide coding regions of cytoplasmic actin genes, Actb and Actg1, are 89% identical. Knockout (KO) of Actb by Cre-mediated del
Externí odkaz:
https://doaj.org/article/213c04ad534c416084dde9f9fa09cb67
Autor:
Claudia Canales Holzeis, Paul Gepts, Robert Koebner, Prem Narain Mathur, Sonia Morgan, María Muñoz-Amatriaín, Travis A. Parker, Edwin M. Southern, Michael P. Timko
Publikováno v:
Plants, Vol 13, Iss 13, p 1818 (2024)
This manuscript reviews two decades of projects funded by the Kirkhouse Trust (KT), a charity registered in the UK. KT was established to improve the productivity of legume crops important in African countries and in India. KT’s requirements for su
Externí odkaz:
https://doaj.org/article/50405c38b22b4823943294243ca23369
Autor:
Maria Razzoli, Angus Lindsay, Michelle L. Law, Christopher M. Chamberlain, William M. Southern, Madeleine Berg, John Osborn, William C. Engeland, Joseph M. Metzger, James M. Ervasti, Alessandro Bartolomucci
Publikováno v:
EBioMedicine, Vol 55, Iss , Pp - (2020)
Background: Duchenne muscular dystrophy (DMD) is caused by the loss of dystrophin. Severe and ultimately lethal, DMD progresses relatively slowly in that patients become wheelchair bound only around age twelve with a survival expectancy reaching the
Externí odkaz:
https://doaj.org/article/67a91b5560474402bcbe5aa9b03fbaf4
Autor:
William M Southern, Anna S Nichenko, Daniel D Shill, Corey C Spencer, Nathan T Jenkins, Kevin K McCully, Jarrod A Call
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172551 (2017)
We tested the hypothesis that a 6-week regimen of simvastatin would attenuate skeletal muscle adaptation to low-intensity exercise. Male C57BL/6J wildtype mice were subjected to 6-weeks of voluntary wheel running or normal cage activities with or wit
Externí odkaz:
https://doaj.org/article/39aa892590d0421a95a66bbb4069d67b
Autor:
Lauren J. Sundby, William M. Southern, Katelin M. Hawbaker, Jesús M. Trujillo, Benjamin J. Perrin, James M. Ervasti
Publikováno v:
Molecular Biology of the Cell. 33
Actbc–g Actg1–/– mice expressing only γ-actin from an edited Actbc–g allele have growth and survival defects despite expressing normal levels of γ-actin. Cell and auditory phenotypes associated with Actg1 KO were rescued by γ-actin express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64bc16fb64b5cf2a9ba8ec152a563f86
https://doi.org/10.1091/mbc.e22-02-0054
https://doi.org/10.1091/mbc.e22-02-0054
Autor:
Franciane Chevot, Claire Fergus, Mathias O. Senge, John M. Southern, Stephen J. Connon, Mashael A. Alqasem, Vincent P. Kelly, Emiliano Sorrentino, Ciara McDonnell, Michelle Cotter, Karsten Hokamp
Publikováno v:
Nucleic Acids Research
Base-modification can occur throughout a transfer RNA molecule; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. Previously, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17835b015b59f2a046cdfd5f31bb5607
https://doi.org/10.1093/nar/gkab289
https://doi.org/10.1093/nar/gkab289
Publikováno v:
Current Biology
Self-medication refers to the process by which a host suppresses or prevents the deleterious effects of parasitism and other causes of illness via behavioural means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13804f9199d60c04bab3e4590ba8a5f7
https://pubmed.ncbi.nlm.nih.gov/35134354
https://pubmed.ncbi.nlm.nih.gov/35134354
Autor:
Alexandra Pokhilko, Aurora Piñas Fernández, Kieron D Edwards, Megan M Southern, Karen J Halliday, Andrew J Millar
Publikováno v:
Molecular Systems Biology, Vol 8, Iss 1, Pp 1-13 (2012)
Abstract Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can b
Externí odkaz:
https://doaj.org/article/9c97ca926dd3484daf1944f77a75b81c
Autor:
Anna Flis, Aurora Piñas Fernández, Tomasz Zielinski, Virginie Mengin, Ronan Sulpice, Kevin Stratford, Alastair Hume, Alexandra Pokhilko, Megan M. Southern, Daniel D. Seaton, Harriet G. McWatters, Mark Stitt, Karen J. Halliday, Andrew J. Millar
Publikováno v:
Open Biology, Vol 5, Iss 10 (2015)
Our understanding of the complex, transcriptional feedback loops in the circadian clock mechanism has depended upon quantitative, timeseries data from disparate sources. We measure clock gene RNA profiles in Arabidopsis thaliana seedlings, grown with
Externí odkaz:
https://doaj.org/article/4ee84592a7124c0c979fa3f37779edac