Zobrazeno 1 - 10
of 99
pro vyhledávání: '"M. SHAHAR YAR"'
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100042- (2022)
Cancer is one of the leading causes of death globally, around 10 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe emergence of drug resista
Externí odkaz:
https://doaj.org/article/02200759c7d44c6a831d8b6b3dc9abfd
Autor:
Kashif Haider, Neelima Shrivastava, Ankita Pathak, Rikeshwer Prasad Dewangan, Shaikh Yahya, M. Shahar Yar
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100258- (2022)
In recent times cancer has become one of the leading causes of death. Globally around 11 million deaths are reported every year due to cancer. Some clinically approved anticancer drugs play a riveting role in its treatment. Still, due to the severe e
Externí odkaz:
https://doaj.org/article/fcbe7b4fdf584a69b68723bdca9498d8
Autor:
Prasanna A. Yakkala, Samir R. Panda, Syed Shafi, V. G. M. Naidu, M. Shahar Yar, Philemon N. Ubanako, Samson A. Adeyemi, Pradeep Kumar, Yahya E. Choonara, Eugene V. Radchenko, Vladimir A. Palyulin, Ahmed Kamal
Publikováno v:
Molecules, Vol 27, Iss 21, p 7642 (2022)
A series of new 1,2,4-triazolo-linked bis-indolyl conjugates (15a–r) were prepared by multistep synthesis and evaluated for their cytotoxic activity against various human cancer cell lines. It was observed that they were more susceptible to colon a
Externí odkaz:
https://doaj.org/article/a27cf8f603c54ec78deb587de2126734
Autor:
Mohammad Mustaqeem Abdullah, Nasir A. Siddiqui, Ramzi A. Mothana, Fahd A. Nasr, Adnan J. Al-Rehaily, Omer M. Almarfadi, Shahid Karim, Kashif Haider, Md Rafi Haider, M. Shahar Yar
Publikováno v:
Arabian Journal of Chemistry, Vol 14, Iss 4, Pp 103034- (2021)
Benzofuran is a heterocyclic scaffold present in various natural products and possess excellent pharmacological properties including anti-tubercular activity as well. A novel series 26 compound containing 3-chlorobenzofuran derivatives are designed,
Externí odkaz:
https://doaj.org/article/b5bb0777d43249bba953052e5dd26d43
Publikováno v:
Journal of the Serbian Chemical Society, Vol 72, Iss 1, Pp 5-11 (2007)
In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI–CXI). These chalcones were further reacted with hydrazine hydrate in etha
Externí odkaz:
https://doaj.org/article/25282268f10d40ae82a1a7b3b44bceb0
Publikováno v:
Journal of the Serbian Chemical Society, Vol 71, Iss 12, Pp 1269-1273 (2006)
The targeted pro-drug is a classical pro-drug design often representing a non-specific chemical approach to mask undesirable drug properties, such as limited bioavailability, lack of site specificity, and chemical instability. On the other hand, targ
Externí odkaz:
https://doaj.org/article/a5bd5f543aa3435e865d0a0c93d4a466
Autor:
Gourav Grover, Rohit Pal, Rohit Bhatia, M. Shahar Yar, Rajarshi Nath, Shamsher Singh, Khadga Raj, Bhupinder Kumar, Md Jawaid Akhtar
Publikováno v:
Medicinal Chemistry Research. 31:781-793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a249c07b66ad8cd2431b55b315d8124b
https://doi.org/10.1007/s00044-022-02880-4
https://doi.org/10.1007/s00044-022-02880-4
Autor:
Kashif Haider, Anku Sharma, M Shahar Yar, Prasanna Anjaneyulu Yakkala, Syed Shafi, Ahmed Kamal
Publikováno v:
Expert Opinion on Drug Discovery. 17:247-257
Hyperactivated RAS signaling is reported in 13% of all human cancers, in which ~80% resulted due to KRAS mutations alone. Direct inhibition of KRAS is an important aspect in treating KRAS-related tumors. Despite the efforts of more than four decades,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2138982c1d1846fbf1d9ddfd9fe9c2dc
https://doi.org/10.1080/17460441.2022.2029842
https://doi.org/10.1080/17460441.2022.2029842
Publikováno v:
Expert Opinion on Drug Discovery. 15:823-832
A novel anticancer therapy is the need of the hour due to growing incidences of resistance to first line cancer chemotherapy. Synthetic lethality (SL) is one of the new age treatment methods being explored for combating the resistance to anticancer a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691fd7744bad82db7d5673b502bce2e3
https://doi.org/10.1080/17460441.2020.1744560
https://doi.org/10.1080/17460441.2020.1744560
Publikováno v:
Archiv der PharmazieREFERENCES. 355(10)
A new series of 2-aminobenzothiazole derivatives was designed, synthesized and evaluated for their anticancer activity against the MCF7, MDAMB-231, and HepG2 cancer cell lines. All synthesized derivatives (8a-8n) demonstrated moderate to high antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db41fa742390da06d8d810c5a7328617
https://pubmed.ncbi.nlm.nih.gov/35665957
https://pubmed.ncbi.nlm.nih.gov/35665957