Zobrazeno 1 - 10
of 30
pro vyhledávání: '"M. S. Wolin"'
Publikováno v:
Journal of Applied Physiology. 81:349-354
In this study we tested the hypothesis that lactate, independent of changes in pH, can affect skeletal muscle blood flow through arteriolar dilation that may be mediated by guanosine 3',5'-cyclic monophosphate. Isolated, cannulated, and pressurized f
Publikováno v:
Journal of Cardiovascular Pharmacology. 23:664-668
We investigated the vasoactive actions of the wound-healing agent tetrachlorodecaoxygen (TCDO). TCDO (20 microM) had no direct effect on tone in isolated calf pulmonary arteries precontracted with potassium with or without 1 microM reduced hemoglobin
Publikováno v:
The Journal of Immunology. 147:3096-3103
It is currently thought that pulmonary eosinophils play a proinflammatory role in bronchial asthma. Leukotriene B4 (LTB4) is being considered as an important mediator in regulating eosinophil function because of its potent activities in inducing leuk
Publikováno v:
Cellular and molecular biology (Noisy-le-Grand, France). 51(4)
Hyperglycemia represents the main cause of complication of diabetes mellitus and oxidative stress, resulting from increased generation of reactive oxygen species (ROS), and plays a crucial role in their pathogenesis. Impairment of vascular responses
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
Nitric oxide (NO)-derived species could potentially react with arachidonic acid to generate novel vasoactive metabolites. We studied the reaction of arachidonic acid with nitrogen dioxide (NO2), a free radical that originates from NO oxidation. The r
Autor:
K M, Mohazzab, M S, Wolin
Publikováno v:
Advances in experimental medicine and biology. 475
Publikováno v:
Advances in experimental medicine and biology. 471
In summary, NO is capable of decreasing mitochondrial respiration in a variety of mammalian tissues. This effect is mediated primarily via binding of NO to the O2 binding site of cytochrome oxidase. This highly sensitive interaction presumably reflec
Publikováno v:
Biochemistry. Biokhimiia. 63(7)
Nitric oxide has several signalling mechanisms that can potentially control force generation by vascular smooth muscle. Some of these mechanisms include the stimulation of cGMP production by the soluble heme-containing form of guanylate cyclase (sGC)
Publikováno v:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 16(10)
It is well documented that nitric oxide (NO) suppresses the function of a number of mitochondrial enzymes. Our recent studies found that endogenous NO may play an important role in the modulation of tissue oxygen (O2) consumption and cellular respira
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
The coronary vasodilator effect of bradykinin (BK) in the rat is independent of NO but dependent on activation of phospholipases with involvement of cytochrome P450 mono-oxygenase (P450) and stimulation of Ca++-activated K+ channels, implicating an u