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Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

Autor: Herbert Yu, Natasha A. Barry, Carmen J. Booth, Thomas W. Cullen, Andrew L. Goodman, Patrick H. Degnan, Emily E. Putnam, M. S. Trent, E. A. Rundell, Whitman B. Schofield

Publikováno v: Science. 347:170-175

Gut microbes resist inflammation It is vital to human well-being that our gut microbiota can be distinguished from harmful, but often very similar, organisms. Cullen et al. begin to analyze how one dominant symbiont, Bacteroidetes thetaiotaomicron ,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49742983883d9f880298adc0153d4aaf
https://doi.org/10.1126/science.1260580

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Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance

Autor: M. S. Lee, Marcelo C. Sousa, Toni Kline, Samuel I. Miller, Heather B. Felise, Christopher M. Stead, H.V. Nguyen, M. S. Trent

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:1507-1510

Three sets of novel 4-deoxy-l-arabinose analogs were synthesized and evaluated as potential inhibitors of the bacterial resistance mechanism in which lipid A, on the outer membrane, is modified with 4-amino-4-deoxy-l-arabinose (l-Ara4N). One compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ca63204ea47af0676224ae8aeba89
https://doi.org/10.1016/j.bmcl.2007.12.061

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Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

Autor: T W, Cullen, W B, Schofield, N A, Barry, E E, Putnam, E A, Rundell, M S, Trent, P H, Degnan, C J, Booth, H, Yu, A L, Goodman

Publikováno v: Science (New York, N.Y.). 347(6218)

Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well understood. We have found that human gut microbes from all dominant phyla are resistant to high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7001d37a2b731f1b38fbcb8b57c9d683
https://pubmed.ncbi.nlm.nih.gov/25590752

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An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor

Autor: M S, Trent, A A, Ribeiro, S, Lin, R J, Cotter, C R, Raetz

Publikováno v: The Journal of biological chemistry. 276(46)

Attachment of the cationic sugar 4-amino-4-deoxy-l-arabinose (l-Ara4N) to lipid A is required for the maintenance of polymyxin resistance in Escherichia coli and Salmonella typhimurium. The enzymes that synthesize l-Ara4N and transfer it to lipid A h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efe666506df430fa7464c3de980ec2d6
https://pubmed.ncbi.nlm.nih.gov/11535604

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Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm

Autor: M S, Trent, A A, Ribeiro, W T, Doerrler, S, Lin, R J, Cotter, C R, Raetz

Publikováno v: The Journal of biological chemistry. 276(46)

Polymyxin-resistant mutants of Escherichia coli and Salmonella typhimurium accumulate a novel minor lipid that can donate 4-amino-4-deoxy-l-arabinose units (l-Ara4N) to lipid A. We now report the purification of this lipid from a pss(-) pmrA(C) mutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b18c3ddbcc6f488a7de99ad77e9ab1b7
https://pubmed.ncbi.nlm.nih.gov/11535605

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HlyC, the internal protein acyltransferase that activates hemolysin toxin: roles of various conserved residues in enzymatic activity as probed by site-directed mutagenesis

Autor: M. L. Ernst-Fonberg, Lesa M.S. Worsham, M. S. Trent

Publikováno v: Biochemistry. 38(29)

Hemolysin, a toxic protein produced by pathogenic Escherichia coli, is one of a family of homologous toxins and toxin-processing proteins produced by Gram-negative bacteria. HlyC, an internal protein acyltransferase, converts it from nontoxic prohemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e284591838bc9d23d83e79d3e3cd439f
https://pubmed.ncbi.nlm.nih.gov/10413532

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The biochemistry of hemolysin toxin activation: characterization of HlyC, an internal protein acyltransferase

Autor: M. L. Ernst-Fonberg, Lesa M.S. Worsham, M. S. Trent

Publikováno v: Biochemistry. 37(13)

Hemolysin toxin produced and secreted by pathogenic Escherichia coli is one of a family of cytolytic, structurally homologous protein toxins known as RTX (repeats in toxin) toxins. RTX toxins are products of a gene cluster, CABD. The A gene product,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b49bf30b19b191eefab47f4874357e0
https://pubmed.ncbi.nlm.nih.gov/9521785

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A balloon-expandable intravascular stent for obliterating experimental aortic dissection

Autor: M S, Trent, V, Parsonnet, R, Shoenfeld, B J, Brener, D E, Eisenbud, A S, Novick, A Y, Campbell, M, Ferrara-Ryan, A, Villanueva

Publikováno v: Journal of vascular surgery. 11(5)

Acute aortic dissection is a life-threatening condition. Aggressive hypotensive drug therapy is the initial treatment of choice, although emergent surgical intervention is often warranted. We evaluated the efficacy of a balloon-expandable intravascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12f34be8fada1a9c0a0a309b10b4656f
https://pubmed.ncbi.nlm.nih.gov/2335837

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