Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M. S. Madhusudhan"'
Autor:
Tirtha Mandal, Soorya Gnanasegaran, Golding Rodrigues, Shalini Kashipathi, Anurag Tiwari, Ashvini Kumar Dubey, Sanghamitra Bhattacharjee, Yogendra Manjunath, Subith Krishna, M. S. Madhusudhan, Maloy Ghosh
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-22 (2024)
Abstract Background High levels of LLT1 expression have been found in several cancers, where it interacts with CD161 on NK cells to facilitate tumor immune escape. Targeting LLT1 could potentially relieve this inhibitory signal and enhance anti-tumor
Externí odkaz:
https://doaj.org/article/2711c1481c15447aa9107618730b296c
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The strength of molecular interactions is characterized by their dissociation constants (K D). Only high-affinity interactions (K D ≤ 10−8 M) are extensively investigated and support binary on/off switches. However, such analyses have di
Externí odkaz:
https://doaj.org/article/4096a9a01d364f6e94a974a94769f2af
Autor:
Neeladri Sen, Tejashree Rajaram Kanitkar, Ankit Animesh Roy, Neelesh Soni, Kaustubh Amritkar, Shreyas Supekar, Sanjana Nair, Gulzar Singh, M S Madhusudhan
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007419 (2019)
Despite Nipah virus outbreaks having high mortality rates (>70% in Southeast Asia), there are no licensed drugs against it. In this study, we have considered all 9 Nipah proteins as potential therapeutic targets and computationally identified 4 putat
Externí odkaz:
https://doaj.org/article/5191642367954908be944f3704404b8d
Autor:
Yogendra Ramtirtha, M. S. Madhusudhan
SUMOylation is a post translational modification that involves covalent attachment of SUMO C-terminus to side chain amino group of lysine residues in target proteins. Disruption of the modification has been linked to neurodegenerative diseases and ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e2dbeb9cc79d004f8badda74121ba12
https://doi.org/10.1101/2022.08.19.504577
https://doi.org/10.1101/2022.08.19.504577
Autor:
Kinya Hotta, Soumya Ranganathan, Ruchuan Liu, Fei Wu, Hiroaki Machiyama, Rong Gao, Hiroaki Hirata, Neelesh Soni, Takashi Ohe, Christopher W V Hogue, M S Madhusudhan, Yasuhiro Sawada
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003532 (2014)
Mechanical stretch-induced tyrosine phosphorylation in the proline-rich 306-residue substrate domain (CasSD) of p130Cas (or BCAR1) has eluded an experimentally validated structural understanding. Cellular p130Cas tyrosine phosphorylation is shown to
Externí odkaz:
https://doaj.org/article/5ef1f265b25545e49fcbeed1b7bc74e3
Autor:
Tejashree Rajaram, Kanitkar, Neeladri, Sen, Sanjana, Nair, Neelesh, Soni, Kaustubh, Amritkar, Yogendra, Ramtirtha, M S, Madhusudhan
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2305
Biological processes are often mediated by complexes formed between proteins and various biomolecules. The 3D structures of such protein-biomolecule complexes provide insights into the molecular mechanism of their action. The structure of these compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8080216129e7415ee808415394cbcc80
https://pubmed.ncbi.nlm.nih.gov/33950384
https://pubmed.ncbi.nlm.nih.gov/33950384
Autor:
Kanika Bajaj, M S Madhusudhan, Bharat V Adkar, Purbani Chakrabarti, C Ramakrishnan, Andrej Sali, Raghavan Varadarajan
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 12, p e241 (2007)
When incorporated into a polypeptide chain, proline (Pro) differs from all other naturally occurring amino acid residues in two important respects. The phi dihedral angle of Pro is constrained to values close to -65 degrees and Pro lacks an amide hyd
Externí odkaz:
https://doaj.org/article/5dae1fd646224f5cbc4ecd953189ed0a
Autor:
Ursula, Pieper, Narayanan, Eswar, Fred P, Davis, Hannes, Braberg, M S, Madhusudhan, Andrea, Rossi, Marc, Marti-Renom, Rachel, Karchin, Ben M, Webb, David, Eramian, Min-Yi, Shen, Libusha, Kelly, Francisco, Melo, Andrej, Sali
Publikováno v:
Nucleic Acids Research
MODBASE (http://salilab.org/modbase) is a database of annotated comparative protein structure models for all available protein sequences that can be matched to at least one known protein structure. The models are calculated by MODPIPE, an automated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27518478d6d3ce887b9d1b79a3cc0abc
https://pubmed.ncbi.nlm.nih.gov/16381869
https://pubmed.ncbi.nlm.nih.gov/16381869
Autor:
M. S. Madhusudhan, Marc A. Marti-Renom, Narayanan Eswar, Bino John, Ursula Pieper, Rachel Karchin, Min-Yi Shen, Andrej Sali
Publikováno v:
The Proteomics Protocols Handbook ISBN: 9781588293435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27cd006a786c5d7f11fab322d892915d
https://doi.org/10.1385/1-59259-890-0:831
https://doi.org/10.1385/1-59259-890-0:831
Autor:
Yi, Yang, Lixin, Li, Guang W, Wong, Steven A, Krilis, M S, Madhusudhan, Andrej, Sali, Richard L, Stevens
Publikováno v:
The Journal of biological chemistry. 277(28)
A cDNA was isolated from interleukin 3-developed, mouse bone marrow-derived mast cells (MCs) that contained an insert (designated mRasGRP4) that had not been identified in any species at the gene, mRNA, or protein level. By using a homology-based clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0e3a9d6682c3e38155b5d374c5587b3
https://pubmed.ncbi.nlm.nih.gov/11956218
https://pubmed.ncbi.nlm.nih.gov/11956218