Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

Autor: K. L. Becker, V. Aimanianda, X. Wang, M. S. Gresnigt, A. Ammerdorffer, C. W. Jacobs, R. P. Gazendam, L. A. B. Joosten, M. G. Netea, J. P. Latgé, F. L. van de Veerdonk

Publikováno v: mBio, Vol 7, Iss 3 (2016)

ABSTRACT Chitin is an important cell wall component of Aspergillus fumigatus conidia, of which hundreds are inhaled on a daily basis. Previous studies have shown that chitin has both anti- and proinflammatory properties; however the exact mechanisms

Externí odkaz: https://doaj.org/article/40ccab90071b47dabbc8eeb33ac3046b

In vitro infection models to study fungal-host interactions.

Autor: Last A; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Beutenbergstrasse 11a, 07745, Jena, Germany., Maurer M; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.; Institute of Biochemistry II, Jena University Hospital, Nonnenplan 2,07743, Jena, Germany., S Mosig A; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.; Institute of Biochemistry II, Jena University Hospital, Nonnenplan 2,07743, Jena, Germany., S Gresnigt M; Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Beutenbergstrasse 11a, 07745, Jena, Germany., Hube B; Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Beutenbergstrasse 11a, 07745, Jena, Germany.; Institute of Microbiology, Friedrich Schiller University, Neugasse 24, 07743, Jena, Germany.

Publikováno v: FEMS microbiology reviews [FEMS Microbiol Rev] 2021 Sep 08; Vol. 45 (5).