Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions

Autor: M. S. Drenichev, E. O. Dorinova, I. V. Varizhuk, V. E. Oslovsky, M. A. Varga, R. S. Esipov, D. D. Lykoshin, C. S. Alexeev

Publikováno v: Doklady. Biochemistry and biophysics. 503(1)

Abstract In this work, a comparative analysis of the conditions of transglycosylation reactions catalyzed by E. coli nucleoside phosphorylases was carried out, and the optimal conditions for the formation of various nucleosides were determined. Under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fb8caf9c863f9eb8ed1e56ab978e28
https://pubmed.ncbi.nlm.nih.gov/35538278

Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

Autor: A A, Zenchenko, M S, Drenichev, I A, Ilyicheva, S N, Mikhailov

Publikováno v: Molecular Biology

The emergence of new viruses and resistant strains of pathogenic microorganisms has become a powerful stimulus in the search for new drugs. Nucleosides are a promising class of natural compound, and more than a hundred drugs have already been created

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4545a71449c0a3010c8e5c2f5cccfe64
https://pubmed.ncbi.nlm.nih.gov/34955556

Einseitige Borat‐Veresterung während enzymatischer Nukleosid‐phosphorolyse: Scheinbare Gleichgewichtsverschiebungen und kinetische Auswirkungen**.

Autor: Kaspar, Felix^1,2 (AUTHOR) felix.kaspar@tu-bs.de, Brandt, Felix³ (AUTHOR), Westarp, Sarah^2,4 (AUTHOR), Eilert, Lea^1,5 (AUTHOR), Kemper, Sebastian⁶ (AUTHOR), Kurreck, Anke^2,4 (AUTHOR), Neubauer, Peter² (AUTHOR), Jacob, Christoph R.³ (AUTHOR), Schallmey, Anett¹ (AUTHOR)

Publikováno v: Angewandte Chemie. 5/8/2023, Vol. 135 Issue 20, p1-8. 8p.

Biased Borate Esterification during Nucleoside Phosphorylase-Catalyzed Reactions: Apparent Equilibrium Shifts and Kinetic Implications.

Autor: Kaspar F; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.; Chair of Bioprocess Engineering, Institute of Biotechnology, Faculty III Process Sciences, Technische Universität Berlin, Ackerstraße 76, 13355, Berlin, Germany., Brandt F; Institute of Physical and Theoretical Chemistry, Technische Universität Braunschweig, Gaußstraße 17, 38106, Braunschweig, Germany., Westarp S; Chair of Bioprocess Engineering, Institute of Biotechnology, Faculty III Process Sciences, Technische Universität Berlin, Ackerstraße 76, 13355, Berlin, Germany.; BioNukleo GmbH, Ackerstraße 76, 13355, Berlin, Germany., Eilert L; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.; Present address: Department Structure and Function of Proteins, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany., Kemper S; Institute for Chemistry, Technische Universität Berlin, Straße des 17. Juni 135, 10623, Berlin, Germany., Kurreck A; Chair of Bioprocess Engineering, Institute of Biotechnology, Faculty III Process Sciences, Technische Universität Berlin, Ackerstraße 76, 13355, Berlin, Germany.; BioNukleo GmbH, Ackerstraße 76, 13355, Berlin, Germany., Neubauer P; Chair of Bioprocess Engineering, Institute of Biotechnology, Faculty III Process Sciences, Technische Universität Berlin, Ackerstraße 76, 13355, Berlin, Germany., Jacob CR; Institute of Physical and Theoretical Chemistry, Technische Universität Braunschweig, Gaußstraße 17, 38106, Braunschweig, Germany., Schallmey A; Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 May 08; Vol. 62 (20), pp. e202218492. Date of Electronic Publication: 2023 Feb 24.

Synthesis of Fluorine-Containing Analogues of Purine Deoxynucleosides: Optimization of Enzymatic Transglycosylation Conditions.

Autor: Drenichev, M. S.¹ (AUTHOR), Dorinova, E. O.¹ (AUTHOR), Varizhuk, I. V.¹ (AUTHOR), Oslovsky, V. E.¹ (AUTHOR), Varga, M. A.¹ (AUTHOR), Esipov, R. S.² (AUTHOR), Lykoshin, D. D.² (AUTHOR), Alexeev, C. S.¹ (AUTHOR) micelle@mail.ru

Publikováno v: Doklady Biochemistry & Biophysics. Apr2022, Vol. 503 Issue 1, p52-58. 7p.