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Cellular engineering and therapy in combination with cord blood allografting in pediatric recipients

Autor: M S Cairo, Dean A. Lee, Colleen Delaney, Nidale Tarek

Publikováno v: Bone marrow transplantation. 51(1)

Cord blood (CB) transplantation is an alternate source of human hematopoietic progenitor cells for allogeneic stem cell transplantation in children and adolescents with both malignant and nonmalignant diseases. Current limitations included delay in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b0137272fb784d689c686bb1ed4d5d
https://pubmed.ncbi.nlm.nih.gov/26367220

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Promoting Education, Mentorship, and Support for Pediatric Research

Autor: P. Van Dyck, A. E. Kohrt, C. I. Dungy, B. P. Dreyer, D. P. Orr, Beth K. Yudkowsky, Russell W. Chesney, Elizabeth R. McAnarney, David J. Schonfeld, E. Rothstein, Matthew W. Gillman, M. S. Cairo, Duane Alexander, F. P. Rivara, P. Ferrieri, L. H. Margolis, John I. Takayama, L. Simpson, Michael Weitzman

Publikováno v: Pediatrics. 107:1447-1450

Pediatricians have an important role to play in the advancement of child health research and should be encouraged and supported to pursue research activities. Education and training in child health research should be part of every level of pediatric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85818cf5532a1de25d79bd94a3928291
https://doi.org/10.1542/peds.107.6.1447

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A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities

Autor: F, Bracho, M D, Krailo, V, Shen, S, Bergeron, V, Davenport, W, Liu-Mares, B R, Blazar, A, Panoskaltsis-Mortari, C, van de Ven, R, Secola, M M, Ames, J M, Reid, G H, Reaman, M S, Cairo

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(1)

A Phase I trial was conducted to determine the safety, biological activity, and hematopoietic recovery by the combination of interleukin 6 (IL-6) and granulocyte-colony stimulating factor (G-CSF) after myelosuppressive chemotherapy in children. Patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::291872cd83c5c9892813844de2a17516
https://pubmed.ncbi.nlm.nih.gov/11205919

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Dose reductions and delays: limitations of myelosuppressive chemotherapy

Autor: M S, Cairo

Publikováno v: Oncology (Williston Park, N.Y.). 14(9 Suppl 8)

Thrombocytopenia occurs at various grades of severity in patients with nonmyeloid malignancies undergoing chemotherapy with myelosuppressive agents. Frequently, it is the major dose-limiting hematologic toxicity, especially in the treatment of potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfa3e20add937131df094df0b8e9eceb
https://pubmed.ncbi.nlm.nih.gov/11033835

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T-cell-rich large B-cell lymphoma in children and adolescents: a clinicopathologic report of six cases from the Children's Cancer Group Study CCG-5961

Autor: M A, Lones, M S, Cairo, S L, Perkins

Publikováno v: Cancer. 88(10)

T-cell-rich large B-cell lymphoma (TCRLBCL) is a morphologic subset of diffuse large B-cell lymphoma that has been confused with Hodgkin disease and reactive lymphadenopathies. To the authors' knowledge the majority of reports of TCRLBCL are from adu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51acddc94657b25d817ea7a8e61c6f2f
https://pubmed.ncbi.nlm.nih.gov/10820362

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A Phase I study of granulocyte-macrophage-colony stimulating factor/interleukin-3 fusion protein (PIXY321) following ifosfamide, carboplatin, and etoposide therapy for children with recurrent or refractory solid tumors: a report of the Children's Cancer Group

Autor: M S, Cairo, M D, Krailo, J A, Weinthal, R, Secola, S, Bergeron, C, van de Ven, B R, Blazar, L, Garrison, G H, Reaman

Publikováno v: Cancer. 83(7)

This Phase I trial was developed to determine the safety, biologic activity, and effects on hematopoietic recovery of PIXY321 following ifosfamide, carboplatin, and etoposide chemotherapy for children with recurrent or refractory solid tumors.Childre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dee2eacfee01af7a4adcb8d50bccc7f1
https://pubmed.ncbi.nlm.nih.gov/9762948

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Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood

Autor: J X, Qian, S M, Lee, Y, Suen, E, Knoppel, C, van de Ven, M S, Cairo

Publikováno v: Blood. 90(8)

Interleukin-15 (IL-15) is an important lymphokine regulating natural killer (NK) activity, T-cell proliferation, and T-cell cytotoxic activities. We hypothesized that the reduced expression and production of IL-15 from cord blood (CB) may contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59b21b765ff43058dca1d76bea89e880
https://pubmed.ncbi.nlm.nih.gov/9376592

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Sequential treatment with rmIL-3 or simultaneous treatment with rmIL-3 or rhIL-11 with thrombopoietin (TPO) fails to enhance in vivo neonatal rat thrombocytopoiesis

Autor: C, van de Ven, G W, Fernandez, T, Herbst, A, Knoppel, M S, Cairo

Publikováno v: Experimental hematology. 25(9)

Multipotent-lineage nondominant growth factors, acting alone or in combination with lineage-dominant cytokines, are known to influence both myelopoiesis and thrombocytopoiesis. Interleukin (IL)-3 and IL-11 stimulate and expand multilineage progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::605d89199c997e78a921397be465e51c
https://pubmed.ncbi.nlm.nih.gov/9257814

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