Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

Autor: José L. Blaya-Cánovas, Carmen Griñán-Lisón, Isabel Blancas, Juan A. Marchal, César Ramírez-Tortosa, Araceli López-Tejada, Karim Benabdellah, Marina Cortijo-Gutiérrez, M. Victoria Cano-Cortés, Pablo Graván, Saúl A. Navarro-Marchal, Jaime Gómez-Morales, Violeta Delgado-Almenta, Jesús Calahorra, María Agudo-Lera, Amaia Sagarzazu, Carlos J. Rodríguez-González, Tania Gallart-Aragón, Christina Eich, Rosario M. Sánchez-Martín, Sergio Granados-Principal

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)

Abstract Background Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles within the tumor, thereby enhancing drug delivery and efficacy for a successful cancer treatment. However, surfac

Externí odkaz: https://doaj.org/article/7eccea89fef54fdfadb06b2ab6ab804f

Nanomedicine as a Promising Tool to Overcome Immune Escape in Breast Cancer

Autor: Alba Navarro-Ocón, Jose L. Blaya-Cánovas, Araceli López-Tejada, Isabel Blancas, Rosario M. Sánchez-Martín, María J. Garrido, Carmen Griñán-Lisón, Jesús Calahorra, Francisca E. Cara, Francisco Ruiz-Cabello, Juan A. Marchal, Natalia Aptsiauri, Sergio Granados-Principal

Publikováno v: Pharmaceutics, Vol 14, Iss 3, p 505 (2022)

Breast cancer is the most common type of malignancy and leading cause of cancer death among women worldwide. Despite the current revolutionary advances in the field of cancer immunotherapy, clinical response in breast cancer is frequently below expec

Externí odkaz: https://doaj.org/article/92f461a934af4aedbab8bf1bd0d83f0e

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An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems

Autor: Maria Victoria Cano-Cortes, Francisco Javier López-Delgado, José M Espejo-Román, Juan D. Unciti-Broceta, Jose Antonio Laz-Ruiz, Juan J. Díaz-Mochón, Patricia Altea-Manzano, Rosario M. Sánchez-Martín

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

In this manuscript, we report the development of a versatile, robust, and stable targeting nanocarrier for active delivery. This nanocarrier is based on bifunctionalized polymeric nanoparticles conjugated to a monoclonal antibody that allows for acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9205eaf1028a044b0a20db676c17bb1
https://doi.org/10.1039/d0nr07145e