Zobrazeno 1 - 10
of 774
pro vyhledávání: '"M. Rybak"'
Autor:
M. Rybak
Publikováno v:
Zemleustrìj, Kadastr ì Monìtorìng Zemelʹ, Vol 0, Iss 2-3, Pp 85-97 (2020)
The article is devoted to the issue of solving the important problem of finding effective methods for organization of land-use in protected areas. Effective economic development is not possible without the organization of rational use and protection
Externí odkaz:
https://doaj.org/article/a26e8fbd65254ecb9e10c90814bdd920
Autor:
Jinhong Xie, Jeffrey M. Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Josie E. Parker, Steven L. Kelly, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methylt
Externí odkaz:
https://doaj.org/article/5bf67aaf3a334a329c3a9686785bf735
Autor:
Jeffrey M. Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I. Thorn, Ashley V. Nywening, Wenbo Ge, Ana C. O. Souza, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno, Josie E. Parker, Steven L. Kelly, Hannah M. Snell, Christina A. Cuomo, P. David Rogers, Jarrod R. Fortwendel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Triazole antifungals function as ergosterol biosynthesis inhibitors and are frontline therapy for invasive fungal infections, such as invasive aspergillosis. The primary mechanism of action of triazoles is through the specific inhibition of
Externí odkaz:
https://doaj.org/article/f05294528fb640d8a22b184dae7ef4b2
Autor:
Yue Zhou, Gregory A. Phelps, Mikayla M. Mangrum, Jemma McLeish, Elise K. Phillips, Jinchao Lou, Christelle F. Ancajas, Jeffrey M. Rybak, Peter M. Oelkers, Richard E. Lee, Michael D. Best, Todd B. Reynolds
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTSystemic infections by Candida spp. are associated with high mortality rates, partly due to limitations in current antifungals, highlighting the need for novel drugs and drug targets. The fungal phosphatidylserine synthase, Cho1, from Candida
Externí odkaz:
https://doaj.org/article/78c37e13beb64762ba0868b9367af010
Autor:
Junyan Liu, Amanda K. Vogel, Jian Miao, Jennifer A. Carnahan, David J. Lowes, Jeffrey M. Rybak, Brian M. Peters
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT As increasing evidence emerges that interstrain genetic diversity among Candida albicans clinical isolates underpins phenotypic variation compared to the reference isolate SC5314, new genetic tools are required to interrogate gene function a
Externí odkaz:
https://doaj.org/article/fadc0234ced749d7b7812a4bc018db12
Autor:
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris
Externí odkaz:
https://doaj.org/article/11fc8a65bf524a0eb9afa9a462436f19
Autor:
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown wh
Externí odkaz:
https://doaj.org/article/57743729eb0c454497ebc0dcd700562d
Autor:
Brooke D. Esquivel, Jeffrey M. Rybak, Katherine S. Barker, Jarrod R. Fortwendel, P. David Rogers, Theodore C. White
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for their roles as transporters. The A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI were cloned into plasmids and overexpressed in a Saccharo
Externí odkaz:
https://doaj.org/article/d8fc063efb164397b16c0f643c17c6f3
Autor:
Tiffany M Rybak, Avani C Modi, Constance A Mara, Rachel B Herbst, Brea A Lauer, Mary Carol Burkhardt, Lori J Stark
Publikováno v:
J Pediatr Psychol
Objective Rapid infant weight gain is associated with later obesity. Novel interventions to prevent rapid infant weight gain that are accessible to infants and families are needed, especially for those at the highest risk. Our aims were to examine: (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27d742a9ff577d5e3d5568701420576
https://doi.org/10.1093/jpepsy/jsac075
https://doi.org/10.1093/jpepsy/jsac075
Autor:
Jeffrey M. Rybak, Katherine S. Barker, José F. Muñoz, Josie E. Parker, Suhail Ahmad, Eiman Mokaddas, Aneesa Abdullah, Rehab S. Elhagracy, Steve L. Kelly, Christina A. Cuomo, P. David Rogers
Publikováno v:
Clin Microbiol Infect
OBJECTIVE: Candida auris has emerged as a health-care-associated and multidrug-resistant fungal pathogen of great clinical concern. As many as 50% of C. auris clinical isolates are reported to be resistant to amphotericin B, but no mechanisms contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3c856fd34db6f84f7f07fe9090cd21
https://doi.org/10.1016/j.cmi.2021.11.024
https://doi.org/10.1016/j.cmi.2021.11.024