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Akademický článek

Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation

Autor: Dorothy A. Lerit, Conrad W. Shebelut, Kristen J. Lawlor, Nasser M. Rusan, Elizabeth R. Gavis, Paul Schedl, Girish Deshpande

Publikováno v: Cell Reports, Vol 18, Iss 4, Pp 831-839 (2017)

The primordial germ cells (PGCs) specified during embryogenesis serve as progenitors to the adult germline stem cells. In Drosophila, the proper specification and formation of PGCs require both centrosomes and germ plasm, which contains the germline

Externí odkaz: https://doaj.org/article/1ceee6a678d3453296e7b3dd6f825a29

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Supplementary Data from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Autor: Richard Chen, Sekwon Jang, Michael P. Snyder, Rena McClory, Jason Harris, Gabor Bartha, Pamela Milani, Zeid M. Rusan, Rose Santiago, Mengyao Tan, Simo V. Zhang, Dattatreya Mellacheruvu, Fábio C.P. Navarro, Eric Levy, Lee D. McDaniel, Rachel Marty Pyke, Sean M. Boyle, Charles W. Abbott

Supplementary Data from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3144b93620d2d48583a464aa8de5ad50
https://doi.org/10.1158/1078-0432.22480829

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Supplementary Table from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Supplementary Table from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0086be9ebf1ffa1f151bb956bb5512fd
https://doi.org/10.1158/1078-0432.22480817.v1

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Data from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Purpose:While immune checkpoint blockade (ICB) has become a pillar of cancer treatment, biomarkers that consistently predict patient response remain elusive due to the complex mechanisms driving immune response to tumors. We hypothesized that a multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225a2c99cc8f1dfb0ef0bef13b61ae7c
https://doi.org/10.1158/1078-0432.c.6530534

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Supplementary Figure from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Supplementary Figure from Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169244e7842d4c08e035f173b4a751a3
https://doi.org/10.1158/1078-0432.22480823

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Akademický článek

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Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

Autor: Gabor Bartha, Jason B. Harris, Simo V. Zhang, Sean Michael Boyle, Michael Snyder, Rena McClory, Pamela Milani, Fabio C. P. Navarro, Rachel Marty Pyke, Eric Levy, Richard Chen, Zeid M. Rusan, Rose Santiago, Lee D. McDaniel, Mengyao Tan, Charles Abbott, Sekwon Jang, Dattatreya Mellacheruvu

Publikováno v: Clinical Cancer Research. 27:4265-4276

Purpose: While immune checkpoint blockade (ICB) has become a pillar of cancer treatment, biomarkers that consistently predict patient response remain elusive due to the complex mechanisms driving immune response to tumors. We hypothesized that a mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da279827929c541b4969e02547f2b21b
https://doi.org/10.1158/1078-0432.ccr-20-4314

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Akademický článek

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Abstract IA14: Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

Publikováno v: Molecular Cancer Research. 21:IA14-IA14

During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec93a98b43e70c9a8169dd836a658ba1
https://doi.org/10.1158/1557-3125.ras23-ia14

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Traip controls mushroom body size by suppressing mitotic defects

Autor: Ryan S. O'Neill, Nasser M. Rusan

Publikováno v: Development

Microcephaly is a failure to develop proper brain size and neuron number. Mutations in diverse genes are linked to microcephaly, including several with DNA damage repair (DDR) functions; however, it is not well understood how these DDR gene mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8bd1bca25ca6a752a6b10aaade51df
https://doi.org/10.1242/dev.199987

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