Výsledky vyhledávání

Reduced expression of annexin A2 is associated with impaired cell surface fibrinolysis and venous thromboembolism

Autor: Katherine A. Hajjar, Mary M. Ruisi, Maria T. DeSancho, Neha Kumar, Huigen Chen, Hannah Fassel

Publikováno v: Blood. 137:2221-2230

Reduced plasma fibrinolysis has been identified as a potential risk factor for venous thromboembolism (VTE), but the role of cell surface fibrinolysis in VTE is unknown. The annexin A2/S100A10 complex serves as a coreceptor for plasminogen and tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c921e0668723b241024010dfbb3b8b
https://doi.org/10.1182/blood.2020008123

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Digital pathology to evaluate PD-L1 IHC scoring as a predictor of outcome with second-line avelumab treatment in patients with non-small cell lung cancer (NSCLC)

Autor: Aslihan Gerhold-Ay, Elena Svenson, Corinna M Wolf, Anja von Heydebreck, Glenn Beeman, P. Alexander Rolfe, Marcus Otte, Juergen Scheuenpflug, M. Ruisi, Ti Cai, Thomas Mrowiec, Parantu K. Shah, Hans Juergen Grote, Violeta Labarta-Beceiro

Publikováno v: Journal of Clinical Oncology. 38:e21539-e21539

e21539 Background: Assessment of programmed death ligand-1 (PD-L1) protein expression using immunohistochemistry (IHC)-based tests is currently the only approved biomarker guiding treatment of non-small cell lung cancer (NSCLC) with checkpoint inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1871395067c3b5ae324480cb0077a92
https://doi.org/10.1200/jco.2020.38.15_suppl.e21539

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Long-term avelumab treatment in patients with advanced non-small cell lung cancer (NSCLC): Post hoc analyses from JAVELIN solid tumour

Autor: David R. Spigel, Karen Kelly, Deborah Jean Lee Wong, Marcis Bajars, Joseph Leach, M. Ruisi, Jaafar Bennouna, Claire F. Verschraegen, Swati Goel, Matthew H. Taylor, Borys Hrinczenko, Juliane Manitz, Nicholas Iannotti, J.L. Gulley, Howard Safran

Publikováno v: Annals of Oncology. 30:v612-v613

Background Avelumab, a human IgG1 anti–PD-L1 monoclonal antibody, is an approved treatment for metastatic Merkel cell carcinoma and platinum-treated urothelial carcinoma. We performed descriptive post hoc analyses to explore characteristics of pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::286002807662de6a531656e78c360553
https://doi.org/10.1093/annonc/mdz260.015

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Assessing the impact of subsequent checkpoint inhibitor (CPI) treatment on overall survival: Post hoc analyses from the phase III JAVELIN Lung 200 study of avelumab vs docetaxel in platinum-treated locally advanced/metastatic non-small cell lung cancer (NSCLC)

Autor: Johan Vansteenkiste, Marcis Bajars, Mustafa Ozguroglu, David R. Spigel, M. Ruisi, J. Manitz, J.C-H. Yang, Kwang Bo Park, Fabrice Barlesi

Publikováno v: Annals of Oncology. 30:v611-v612

Background JAVELIN Lung 200, a randomized, open-label, phase III study, did not meet its primary endpoint of significantly improving overall survival (OS) with avelumab vs docetaxel in patients with PD-L1+ NSCLC. However, OS may have been affected by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59a16fdc0551f1bb437da347999385ff
https://doi.org/10.1093/annonc/mdz260.014

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Markedly Reduced Expression of Annexin A2 Is Associated with Hypofibrinolysis and Provoked and Unprovoked Venous Thromboembolism

Autor: Hannah Fassel, Mary M. Ruisi, Huigen Chen, Maria Teresa De Sancho, Katherine A. Hajjar

Publikováno v: Blood. 134:443-443

Introduction: Recent evidence indicates that plasma hypofibrinolysis, as measured by clot lysis times (CLT) at or above the 90th percentile, can double the risk of venous thromboembolism (VTE). To our knowledge, there are no studies on the role of ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4840011dc6d13ee75e83ebb0b21b7af5
https://doi.org/10.1182/blood-2019-127426

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Abstract 2725: Galectin-9 drives TIM-3 mediated immune suppression

Autor: M. Ruisi, Amit M. Deshpande, Rachel E. Fontana, Dong Zhang, Tilo Senger, Yue Zhang, P. Alexander Rolfe

Publikováno v: Cancer Research. 78:2725-2725

Purpose: Following recent Immunotherapy successes by targeting the checkpoints PD1, PD-L1, and CTLA-4, additional checkpoint inhibitors and their counter-structures are being explored as therapeutic targets to reverse T cell exhaustion and increase T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d0dfe823cea2ad87a76923c3857fb8f
https://doi.org/10.1158/1538-7445.am2018-2725

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European aquifer typology: a practical framework for an overview of major groundwater composition at European scale

Autor: Jsa Vermooten, Jasper Griffioen, P Traversa, F. Wendland, Andres Marandi, Klaus Hinsby, Kristine Walraevens, Andreas Panagopoulos, Marleen Coetsiers, T Melo, M Ruisi, Hélène Pauwels, J Grima, Ralf Kunkel, Ariane Blum, R Gorova

Publikováno v: Environmental Geology
Environmental Geology, Springer-Verlag New York, Inc., 2008, 55 (1), pp.77-85. ⟨10.1007/s00254-007-0966-5⟩

International audience; Groundwater quality is determined by a variety of factors. Petrographic properties of the rocks in the vadose and in the groundwater saturated zones as well as the regional hydrological and hydrodynamic conditions are regarded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20aebb36b769ffe5fa8f2ced640e52c1
https://doi.org/10.1007/s00254-007-0966-5

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