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Akademický článek

Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization

Autor: Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle, John Q. Trojanowski, Virginia M.-Y. Lee

Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that exhibits pathological changes in both tau and synaptic function. AD patients display increases in hyperphosphorylated tau and synaptic activity. Previous studies have individual

Externí odkaz: https://doaj.org/article/6701d14350d140dbb6bdce7263329ac0

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Akademický článek

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Autor: Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle, Susan N. Leight, Lakshmi Changolkar, Hong Xu, Emily S. Meymand, Mia O’Reilly, Bin Zhang, Kurt R. Brunden, John Q. Trojanowski, Virginia M. Y. Lee

Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)

Abstract Background The spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve

Externí odkaz: https://doaj.org/article/09dd55fddba54de1b0145828289b3cae

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Akademický článek

Fundamentals of Scholarly Peer Review: A Workshop for Health Professions Educators on Practicing Scholarly Citizenship

Autor: David P. Way, S. Beth Bierer, Anna T. Cianciolo, Larry Gruppen, Janet M. Riddle, Brian Mavis

Publikováno v: MedEdPORTAL, Vol 17 (2021)

Introduction Education scholarship requires peer reviewers. For novice scholars, reviewing is an important developmental activity that cultivates deeper participation in the scholarship community. Yet getting started with reviewing is challenging for

Externí odkaz: https://doaj.org/article/4817aef7ce7c4266ab12fa04313f864d

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Akademický článek

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Autor: Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk

Publikováno v: Neurobiology of Disease, Vol 136, Iss , Pp 104712- (2020)

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is

Externí odkaz: https://doaj.org/article/2065928935b24bed8f41f6623a293ece

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Supplementary Figures 1 - 6 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

Autor: Brian J. Druker, Michael W. Deininger, Jeffrey W. Tyner, John Apgar, Dennis R. Koop, Kurt W. Vogel, Bryan D. Marks, Steven M. Riddle, Jenny Luo, Huihong You, Kara J. Johnson, Dorian H. LaTocha, Ryan J. MacKenzie, Matthew S. Zabriskie, Lauren T. Adrian, Anupriya Agarwal, Christopher A. Eide, Thomas O'Hare

PDF file - 1469K, Different ABL TKIs demonstrate potency differences in relative cellular and biochemical target inhibition (S1); Incomplete restoration of BCR-ABL signaling activity following washout of dasatinib or ponatinib tracks with intracellul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bb2f349dbdbd12daa46b5865710272
https://doi.org/10.1158/0008-5472.22396247

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Supplementary Tables 1 - 2 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

PDF file - 337K, Summary of mean fluorescence intensity values for levels of CrkL and STAT5 phosphorylation in K562 cells following acute ABL TKI exposure followed by standard and expanded washout (S1); Kinase:inhibitor dissociation off-rates for ABL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464ff7a97c638799f3fd2f9fd2378704
https://doi.org/10.1158/0008-5472.22396238.v1

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Supplementary Figure Legend from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e7b60dba00e64f41fe83e32b81c9f
https://doi.org/10.1158/0008-5472.22396250.v1

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