Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. Richard Sayen"'
Autor:
Scott M Robinson, Ginger Tsueng, Jon Sin, Vrushali Mangale, Shahad Rahawi, Laura L McIntyre, Wesley Williams, Nelson Kha, Casey Cruz, Bryan M Hancock, David P Nguyen, M Richard Sayen, Brett J Hilton, Kelly S Doran, Anca M Segall, Roland Wolkowicz, Christopher T Cornell, J Lindsay Whitton, Roberta A Gottlieb, Ralph Feuer
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004045 (2014)
Coxsackievirus B3 (CVB3), a member of the picornavirus family and enterovirus genus, causes viral myocarditis, aseptic meningitis, and pancreatitis in humans. We genetically engineered a unique molecular marker, "fluorescent timer" protein, within ou
Externí odkaz:
https://doaj.org/article/e79e86a49ce14c5d9d2825e8f6674a0b
Autor:
Jennifer Ramil, Roland Wolkowicz, Diana Lui, Roberta A. Gottlieb, Raquel S. Carreira, M. Richard Sayen, Najib Magee, Jon Sin, Christine A Thornton, Aleksandr Stotland, Giovanni Quarato, Allen M. Andres, Genaro Hernandez
Publikováno v:
Autophagy
Fluorescent Timer, or DsRed1-E5, is a mutant of the red fluorescent protein, dsRed, in which fluorescence shifts over time from green to red as the protein matures. This molecular clock gives temporal and spatial information on protein turnover. To v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545543bae8dd74e22ef19b65bfdb99ab
https://doi.org/10.4161/auto.26501
https://doi.org/10.4161/auto.26501
Autor:
Roberta A. Gottlieb, Chengqun Huang, Cynthia N. Perry-Garza, M. Richard Sayen, Hua Yuan, Eri Iwai-Kanai, Lucy Kim
Publikováno v:
Autophagy. 4:322-329
Autophagy, a highly conserved cellular mechanism wherein various cellular components are broken down and recycled through lysosomes, has been implicated in the development of heart failure. However, tools to measure autophagic flux in vivo have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40e915197410be773d6cd74bf495f4e
https://doi.org/10.4161/auto.5603
https://doi.org/10.4161/auto.5603
Autor:
Jeffery D. Molkentin, Jeffrey Robbins, Nicole H. Purcell, Michael Hambleton, Gerald W. Dorn, N. Scott Blair, M. Richard Sayen, Hanna Osinska, Eric W. Brunskill, Roberta A. Gottlieb, Robert A. Kaiser, Christopher P. Baines
Publikováno v:
Nature. 434:658-662
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators. The mPT pore is tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4113d97e8b49e183342b78d6f37f6fe0
https://doi.org/10.1038/nature03434
https://doi.org/10.1038/nature03434
Autor:
Roland Wolkowicz, M. Richard Sayen, Roberta A. Gottlieb, Kelly S. Doran, Vrushali Mangale, Brett J. Hilton, David P. Nguyen, Shahad Rahawi, Scott M. Robinson, Laura L. McIntyre, Ginger Tsueng, Anca M. Segall, Jon Sin, Bryan M. Hancock, Ralph Feuer, Christopher T. Cornell, Casey Cruz, J. Lindsay Whitton, Nelson Kha, Wesley Williams
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004045 (2014)
PLoS Pathogens
PLoS Pathogens
Coxsackievirus B3 (CVB3), a member of the picornavirus family and enterovirus genus, causes viral myocarditis, aseptic meningitis, and pancreatitis in humans. We genetically engineered a unique molecular marker, “fluorescent timer” protein, withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ce1e10b5c08b0706e890ef10995457
http://europepmc.org/articles/PMC3983045?pdf=render
http://europepmc.org/articles/PMC3983045?pdf=render
Autor:
M. Richard Sayen, Ronald Hartong, Anselmo Sigari Moriscot, Patricia S. C. Wu, Wolfgang H. Dillmann
Publikováno v:
Endocrinology. 138:26-32
Thyroid hormone (T3) increases the transcription of the sarcoplasmic reticulum Ca2+ adenosine triphosphatase (ATPase) gene (SERCA 2) through three thyroid hormone response elements. The existence of repetitive cis elements with different configuratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051be4c5b4d4d8ed9b3d5e5a3528c6f6
https://doi.org/10.1210/endo.138.1.4857
https://doi.org/10.1210/endo.138.1.4857
Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd90c0ce844c4f3e421846469749ba63
https://europepmc.org/articles/PMC3427259/
https://europepmc.org/articles/PMC3427259/
Autor:
M. Richard Sayen, Jeffery D. Molkentin, Roberta A. Gottlieb, Youngil Lee, Shivaji Rikka, Melissa N. Quinsay, Åsa B. Gustafsson
Publikováno v:
Journal of molecular and cellular cardiology. 48(6)
Bnip3 is a member of the BH3-only subfamily of pro-apoptotic Bcl-2 proteins and is associated with loss of cardiac myocytes after a myocardial infarction. Previous studies have demonstrated that Bnip3 induces mitochondrial dysfunction, but the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e948da87fc870a10d48c599aee7505d
https://pubmed.ncbi.nlm.nih.gov/20025887
https://pubmed.ncbi.nlm.nih.gov/20025887
Autor:
Melissa N Quinsay, Shivaji Rikka, M Richard Sayen, Jeffery D Molkentin, Roberta A Gottlieb, Asa B Gustafsson
Publikováno v:
Circulation. 118
Bnip3 is a member of the BH3-only subfamily of pro-apoptotic Bcl-2 proteins and is associated with mitochondrial dysfunction and cell death in the myocardium. The pro-apoptotic Bcl-2 proteins mediate mitochondrial dysfunction independent of the mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8674a3caaabc82d184450528c83504e9
https://doi.org/10.1161/circ.118.suppl_18.s_388-b
https://doi.org/10.1161/circ.118.suppl_18.s_388-b
Autor:
M. Richard Sayen, Roberta A. Gottlieb, Åsa B. Gustafsson, Babak Tashakkor, Chengqun Huang, David J. Granville, Mark Yeager, Cindy Takeuchi, Paul Wentworth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(5)
Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when administered before ischemia, few have been shown to be effective when administered at reperfusion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33423704dfe37e36be1b3588937df7c1
https://pubmed.ncbi.nlm.nih.gov/15469397
https://pubmed.ncbi.nlm.nih.gov/15469397