Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. Rhyan Puno"'
Autor:
Yuhki Saito, Ben R. Hawley, M. Rhyan Puno, Shreya N. Sarathy, Christopher D. Lima, Samie R. Jaffrey, Robert B. Darnell, Scott Keeney, Devanshi Jain
Publikováno v:
Genes & Development. 36:180-194
Mechanisms regulating meiotic progression in mammals are poorly understood. The N6-methyladenosine (m6A) reader and 3′ → 5′ RNA helicase YTHDC2 switches cells from mitotic to meiotic gene expression programs and is essential for meiotic entry,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa0a85f8cc77c9b57f29c1d63f9b34bd
https://doi.org/10.1101/gad.349190.121
https://doi.org/10.1101/gad.349190.121
Autor:
Devanshi Jain, M Rhyan Puno, Cem Meydan, Nathalie Lailler, Christopher E Mason, Christopher D Lima, Kathryn V Anderson, Scott Keeney
Publikováno v:
eLife, Vol 7 (2018)
Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, ‘ketu’, caused by a Ythdc2 missense mutation. Mutant germ cells enter meiosis but
Externí odkaz:
https://doaj.org/article/08ec398323f14159913426dc55b9377a
Autor:
M Rhyan, Puno, Christopher D, Lima
Publikováno v:
Methods in enzymology. 673
The nuclear RNA exosome collaborates with the MTR4 helicase and RNA adaptor complexes to process, surveil, and degrade RNA. Here we outline methods to characterize RNA translocation and strand displacement by exosome-associated helicases and adaptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dffee62ce7a1aacf34acaed8c2c2dcc
https://pubmed.ncbi.nlm.nih.gov/35965016
https://pubmed.ncbi.nlm.nih.gov/35965016
Autor:
M. Rhyan Puno, Christopher D. Lima
Publikováno v:
Cell
RNA quality control relies on co-factors and adaptors to identify and prepare substrates for degradation by ribonucleases such as the 3' to 5' ribonucleolytic RNA exosome. Here, we determined cryogenic electron microscopy structures of human nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b2f8fb29e63fd2027f1cee8f2dba11
https://europepmc.org/articles/PMC9210550/
https://europepmc.org/articles/PMC9210550/
Autor:
M. Rhyan Puno, Christopher D. Lima
Publikováno v:
Helicase Enzymes Part B ISBN: 9780323997737
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beeff94f0f4420f5ed06836abed45e19
https://doi.org/10.1016/bs.mie.2022.03.060
https://doi.org/10.1016/bs.mie.2022.03.060
Autor:
Yuhki, Saito, Ben R, Hawley, M Rhyan, Puno, Shreya N, Sarathy, Christopher D, Lima, Samie R, Jaffrey, Robert B, Darnell, Scott, Keeney, Devanshi, Jain
Publikováno v:
Genesdevelopment. 36(3-4)
Mechanisms regulating meiotic progression in mammals are poorly understood. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5227ee7d460bd9c2bbbc54bd9af7ef34
https://pubmed.ncbi.nlm.nih.gov/35058317
https://pubmed.ncbi.nlm.nih.gov/35058317
Autor:
M. Rhyan Puno, Christopher D. Lima, John C. Zinder, Michael A. DiMattia, Eva-Maria Weick, Kurt Januszyk
Publikováno v:
Cell. 173(7)
Summary The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we reconstituted 14-subunit Mtr4-containing RNA exosomes from Saccharomyces cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d24bd8e7a7f1036021a7439c66d72b
https://pubmed.ncbi.nlm.nih.gov/29906447
https://pubmed.ncbi.nlm.nih.gov/29906447
Autor:
Scott Keeney, Christopher D. Lima, Cem Meydan, Nathalie Lailler, Christopher E. Mason, Kathryn V. Anderson, Devanshi Jain, M. Rhyan Puno
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Mechanisms regulating mammalian meiotic progression are poorly understood. Here we identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant, “ketu”, caused by aYthdc2missense mutation. Mutant germ cells enter meiosis but p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e898f9f98684fd526c878c59f4d237b3
https://doi.org/10.7554/elife.30919
https://doi.org/10.7554/elife.30919
Autor:
Devanshi Jain, Christopher E. Mason, Scott Keeney, Cem Meydan, Kathryn V. Anderson, Nathalie Lailler, M. Rhyan Puno, Christopher D. Lima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90575b4a135d97afffaebfc2a6dbb1f8
https://doi.org/10.7554/elife.30919.049
https://doi.org/10.7554/elife.30919.049
Publikováno v:
Cell. 179:282-282.e1
The RNA exosome is a 3' to 5' ribonuclease that plays a fundamental role in maturation, quality control, and turnover of nearly all types of RNA produced in eukaryotic cells. Here, we present an overview of the structure, composition, and functions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504a0056c2142f4edcfb7b9fb4b07831
https://doi.org/10.1016/j.cell.2019.09.005
https://doi.org/10.1016/j.cell.2019.09.005