Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome

Autor: Li Gao, Ryutaro Kuraji, Martin Jinye Zhang, April Martinez, Allan Radaic, Pachiyappan Kamarajan, Charles Le, Ling Zhan, Changchang Ye, Hélène Rangé, M. Reza Sailani, Yvonne L. Kapila

Publikováno v: npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-14 (2022)

Abstract Dysbiosis of the oral microbiome mediates chronic periodontal disease. Realignment of microbial dysbiosis towards health may prevent disease. Treatment with antibiotics and probiotics can modulate the microbial, immunological, and clinical l

Externí odkaz: https://doaj.org/article/872ae624483a402e94d7d729efe09138

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Autor: Wei Cao, Hayan Lee, Wei Wu, Aubhishek Zaman, Sean McCorkle, Ming Yan, Justin Chen, Qinghe Xing, Nasa Sinnott-Armstrong, Hongen Xu, M. Reza Sailani, Wenxue Tang, Yuanbo Cui, Jia liu, Hongyan Guan, Pengju Lv, Xiaoyan Sun, Lei Sun, Pengli Han, Yanan Lou, Jing Chang, Jinwu Wang, Yuchi Gao, Jiancheng Guo, Gundolf Schenk, Alan Hunter Shain, Fred G. Biddle, Eric Collisson, Michael Snyder, Trever G. Bivona

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)

The epigenetic landscape of esophageal squamous cell carcinoma (ESCC) at genome-wide high resolution is incompletely studied. Here, the authors performed an integrated multi-omics analysis of ESCC and non-tumor tissues to define the genome-wide methy

Externí odkaz: https://doaj.org/article/2d7895e7d5f748e48174da98ff21c531

Isolated Congenital Anosmia and CNGA2 Mutation

Autor: M. Reza Sailani, Inlora Jingga, Seyed Hashem MirMazlomi, Fatemeh Bitarafan, Jonathan A. Bernstein, Michael P. Snyder, Masoud Garshasbi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)

Abstract Isolated congenital anosmia (ICA) is a rare condition that is associated with life-long inability to smell. Here we report a genetic characterization of a large Iranian family segregating ICA. Whole exome sequencing in five affected family m

Externí odkaz: https://doaj.org/article/252479d40f074f6aa2129cbca893ef7e

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

Autor: M. Reza Sailani, Hongyan Guan, Jia Liu, Ming Yan, Nasa Sinnott-Armstrong, Pengju Lv, Eric A. Collisson, Yuanbo Cui, Aubhishek Zaman, Hongen Xu, Qinghe Xing, Jinwu Wang, Michael Snyder, Trever G. Bivona, Justin Chen, Pengli Han, Chang Jing, Jiancheng Guo, Wei Cao, Gundolf Schenk, Yanan Lou, Yuchi Gao, X B Sun, Alan Hunter Shain, Hayan Lee, Wenxue Tang, Sean R. McCorkle, Wei Wu, Lei Sun, Fred G. Biddle

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature communications, vol 11, iss 1

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad307da3ae5049cd674af54c79ee724
http://link.springer.com/article/10.1038/s41467-020-17227-z

Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle

Autor: M. Reza Sailani, Henrik Møller, Hayan Lee, Henriette Pilegaard, Michael Snyder, Birgitte Regenberg, Peter Plomgaard, Jens Frey Halling

Publikováno v: Scientific Reports
Sailani, M R, Halling, J F, Møller, H D, Lee, H, Plomgaard, P, Pilegaard, H, Snyder, M P & Regenberg, B 2019, ' Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle ', Scientific Reports, vol. 9, 3272, pp. 1-11 . https://doi.org/10.1038/s41598-018-37895-8
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D), maintenance of muscle mass and increased metabolic capacity. However, little is known about epigenetic mechanisms that might contribute to these beneficial e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de519b99fcf6eaad6f7650c28c001bb
http://europepmc.org/articles/PMC6397284