Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M. Reza Anari"'
Autor:
Vanessa L. Sherman, M. Reza Anari, Catherine M. Wiscount, Julie A. Krueger, Christopher J. Kochansky, Bobby J. Lucas, Tran Lekhanh O, Joseph P. Vacca, Terry A. Lyle, Bradley K. Wong, Sanderson Philip E, Heidi L. Shimp, Peter D. Williams, Sean Yu, Donnette D. Staas, Kelly L. Savage, S. Dale Lewis, Rebecca B. White, Youwei Yan, Daniel R. McMasters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6900-6916
Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1 position. Using these as lead compounds for further optimization, we identified sites of me
Autor:
Tony K. L. Kiang, Thomas K. H. Chang, M. Reza Anari, Frank S. Abbott, Ping C. Ho, Vincent Tong
Publikováno v:
Toxicological Sciences. 94:261-271
The present study investigated the role of specific human cytochrome P450 (CYP) enzymes in the in vitro metabolism of valproic acid (VPA) by a complementary approach that used individual cDNA-expressed CYP enzymes, chemical inhibitors of specific CYP
Autor:
George A. Doss, Nathan X. Yu, Yohannes Teffera, Suzanne L. Ciccotto, Stella H. Vincent, Wei Tang, Mellissa Creighton, M. Reza Anari, Richard Tschirret-Guth, Donald F. Hobra, John B. Coleman, Jason S. Ngui, David C. Evans
Publikováno v:
Drug Metabolism and Disposition. 34:1367-1375
The pharmacokinetics and metabolism of 1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid (MRL-A), a selective agonist for the sphingosine-1-phosphate 1 (S1P1) receptor, were investigated in rats and dogs. In both
Publikováno v:
Analytical Chemistry. 76:823-832
Despite recent advances in the application of data-dependent liquid chromatography/tandem mass spectrometry (LC/MS/MS) to the identification of drug metabolites in complex biological matrixes, a prior knowledge of the likely routes of biotransformati
Publikováno v:
Analytical Chemistry. 75:469-478
The application of liquid chromatography tandem mass spectrometry for simultaneous analysis of major human cytochrome P450 activities via a single atmospheric pressure ionization (API) LC/MS/MS method has been hampered by the preferred detection of 6
Publikováno v:
Analytical Chemistry. 74:4136-4144
The extensive metabolism and administration of low doses of ethinylestradiol (EE) in preclinical animal species necessitates a sensitive analytical method to quantify the drug at low picogram-per-milliliter concentrations in biological matrixes. A hi
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 742:217-227
A sensitive negative ion chemical ionization (NCI) gas chromatographic-mass spectrometric (GC-MS) method was modified for the quantitation of valproic acid (VPA) metabolites generated from in vitro cDNA-expressed human microsomal cytochrome P450 incu
Autor:
M. Reza Anari, Xiaoxin Cai, Matthew P. Braun, Yuexia Liang, Xiaoyan Chu, Raymond Evers, Magang Shou, Ronda K. Rippley, George A. Doss, Karla G. Cuevas-Licea, Kelem Kassahun
Publikováno v:
Pharmaceutical research. 26(2)
Gaboxadol, a selective extrasynaptic agonist of the delta-containing gamma-aminobutyric acid type A (GABAA) receptor, is excreted in humans into the urine as parent drug and glucuronide conjugate. The goal of this study was to identify the UDP-Glucur
Autor:
Lori J. Gabryelski, Mark Embrey, Thorsten E. Fisher, Alysha M. Day, Linda T. Ecto, John S. Wai, Christopher J. Kochansky, Donnette D. Staas, Carl F. Homnick, Catherine M. Wiscount, Kara A. Stillmock, Michael D. Miller, Joseph P. Vacca, Tran Lekhanh O, Daria J. Hazuda, Peter J. Felock, Vanessa L. Sherman, Terry A. Lyle, M. Reza Anari, ZiQiang Wang, Daniel J. DiStefano, Peter D. Williams, William A. Schleif, Marc V. Witmer
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(16)
A series of 10-hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3- d ]pyridazine-1,9(2 H ,6 H )-diones was synthesized and tested for their inhibition of HIV-1 replication in cell culture. Structure–activity studies indicated that high antiviral
Autor:
Lori J. Gabryelski, Daria J. Hazuda, Thorsten E. Fisher, M. Reza Anari, Terry A. Lyle, Joseph P. Vacca, John S. Wai, Steven D. Young, Boyoung Kim, Matthew M. Zrada, William A. Schleif, Donnette D. Staas, Christopher J. Kochansky, Peter J. Felock
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(23)
A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 12 is active a