Zobrazeno 1 - 10
of 15
pro vyhledávání: '"M. Reza Ahmadian"'
Autor:
Larissa Lamertz, M. Reza Ahmadian, Heinrich J. Huber, Paul Baran, Mohammad Akbarzadeh, Jens M. Moll, Jürgen Scheller, Selina Hansen, Georg H. Waetzig
Publikováno v:
Journal of Biological Chemistry. 293:6762-6775
Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively. Whereas infl
Publikováno v:
Materials & Design. 32:2317-2327
The object of the present work is the development and application of a totally general approach to optimal design of composite laminates where all the required properties for the laminate are explicitly expressed as criteria of the optimisation proce
Autor:
Roland P. Piekorz, Klaus Schulze-Osthoff, Anja Kletke, Fabian Kuck, Constanze Wiek, Reiner U. Jänicke, Stephan Schmidt, Bernd Nürnberg, Harish C. Thakur, M. Reza Ahmadian, Madhurendra Singh, Ion C. Cirstea, Helmut Hanenberg, Frank Essmann
Publikováno v:
Cell Cycle. 9:4469-4473
Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in partic
Publikováno v:
ChemBioChem. 2:570-575
The small guanosine triphosphate (GTP) binding protein Ras is involved in many cellular signal transduction processes leading to cell growth, differentiation and apoptosis. Mutations in ras genes are found in a large number of human tumours. GTP hydr
Publikováno v:
Nature reviews. Molecular cell biology. 13(2)
The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulatio
Autor:
Alexey Rak, Miguel C. Seabra, Kasia Smolarczyk, Filipe C. Maximiano, Marieke A. M. Frasa, Martha Betson, M. Reza Ahmadian, James R. Goldenring, Vania M.M. Braga, Encarnación Lozano, Richard E. Francis
Publikováno v:
Current biology : CB. 20(3)
Summary Background Cell-cell adhesion and intracellular trafficking are regulated by signaling pathways from small GTPases of the Rho, Arf, and Rab subfamilies. How signaling from distinct small GTPases are integrated in a given process is poorly und
Akademický článek
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Autor:
Ioanna-Maria, Karaguni, Peter, Herter, Philip, Debruyne, Slava, Chtarbova, Alice, Kasprzynski, Ulrike, Herbrand, M-Reza, Ahmadian, Karl-Heinz, Glüsenkamp, Günther, Winde, Marc, Mareel, Tarik, Möröy, Oliver, Müller
Publikováno v:
Cancer research. 62(6)
The nonsteroidal anti-inflammatory drug Sulindac has chemopreventive and antitumorigenic properties. Its metabolites induce apoptosis and inhibit signaling pathways critical for malignant transformation, including the Ras pathway. Here we show that t
Autor:
M. Reza Ahmadian, Lars C. Haeusler, Onno Kranenburg, Francis P.G. van Horck, Wouter H. Moolenaar
Publikováno v:
The Journal of biological chemistry. 276(7)
Rho family GTPases control numerous cellular processes including cytoskeletal reorganization and transcriptional activation. Rho GTPases are activated by guanine nucleotide exchange factors (GEFs) which stimulate the exchange of bound GDP for GTP. We
Publikováno v:
FEBS Letters. (2):253-257
The invariant threonine-62, which occurs in the effector region of all GTP/GDP-binding regulatory proteins, was substituted via site-directed mutagenesis by alanine and serine in the elongation factor Tu from Thermus thermophilus. The altered protein