Zobrazeno 1 - 10 of 10 pro vyhledávání: '"M. Ray V. Finlay"'
1
Total synthesis of 26-hydroxy-epothilone B and related analogs via a macrolactonization based strategy
Autor: S. Ninkovic, Kyriacos C. Nicolaou, F. Sarabia, M. Ray V. Finlay
Publikováno v: Tetrahedron. 54:7127-7166
The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxy-epothilone B ( 7 ), prepared via the macrolactonization strategy, served as a common precursor to the designed epothilones described. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80c8e7d756496df45d70491d6bbf2296
https://doi.org/10.1016/s0040-4020(98)00352-4
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2
Probing the Ring Size of Epothilones: Total Synthesis of [14]-, [15]-, [17]-, and [18]Epothilones A
Autor: M. Ray V. Finlay, Christopher N. Boddy, Kyriacos C. Nicolaou, F. Sarabia, S. Ninkovic
Publikováno v: Angewandte Chemie International Edition. 37:81-84
Unfamiliar rings. The pharmocophore of epothilone A does not tolerate changes in ring size. The 14-, 15-, 17-, and 18-membered ring analogues 1 (n = 1, 2, 4, 5) of epothilone and their deoxy counterparts show only low levels of activity in tubulin po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe412a8b64a5feb45e0b4bd01f3def82
https://doi.org/10.1002/(sici)1521-3773(19980202)37:1/2<81::aid-anie81>3.0.co
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7
Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells
Autor: Nicolas Winssinger, Yun He, S. Ninkovic, Joaquin Pastor, Dionisios Vourloumis, Pascal Verdier-Pinard, Pareskevi Giannakakou, Frank Roschangar, Kyriacos C. Nicolaou, F. Sarabia, N. Paul King, M. Ray V. Finlay, Tianhu Li, Ernest Hamel, Hans Vallberg
Publikováno v: Angewandte Chemie: International Edition, Vol. 36, No 19 (1997) pp. 2097-2103
A library of epothilone A and B analogues, which was constructed by solid-phase combinatorial synthesis using SMART Microreactors and solution chemistry, was screened in two different tubulin binding assays. Selected compounds were subjected to cytot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d3a74ddd8560d9c47c7f528829ee23
https://archive-ouverte.unige.ch/unige:24442
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8
Synthesis of 16-desmethylepothilone B: improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues
Autor: Antony Bigot, M. Ray V. Finlay, Kyriacos C. Nicolaou, David Hepworth, N. Paul King, Barbara Werschkun
Publikováno v: Chemical Communications. :519-520
During a synthesis of 16-desmethylepothilone B new methods for the convergent and highly stereoselective synthesis of epothilone B and analogues were developed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0cbafca794afce8bee3c7d79910f96c
https://doi.org/10.1039/a809954e
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9
Total synthesis of 26-hydroxyepothilone B and related analogues
Autor: M. Ray V. Finlay, Francisco Sarabia, S. Ninkovic, Tianhu Li, Kyriacos C. Nicolaou
Publikováno v: Chemical Communications. :2343-2344
A series of 26-substituted epothilones B (3, 22, 23a–n and 24a–h,j–l,o) have been constructed by total synthesis involving a selective Wittig olefination, an aldol reaction and a macrolactonization as key steps.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7390f91d29addb1efcb60e54556aad85
https://doi.org/10.1039/a705845d
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10
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