Zobrazeno 1 - 10 of 13 pro vyhledávání: '"M. R. Sanderson"'
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Akademický článek
Norms and values in sociohydrological models
Autor: M. Roobavannan, T. H. M. van Emmerik, Y. Elshafei, J. Kandasamy, M. R. Sanderson, S. Vigneswaran, S. Pande, M. Sivapalan
Publikováno v: Hydrology and Earth System Sciences, Vol 22, Pp 1337-1349 (2018)
Sustainable water resources management relies on understanding how societies and water systems coevolve. Many place-based sociohydrology (SH) modeling studies use proxies, such as environmental degradation, to capture key elements of the social co
Externí odkaz: https://doaj.org/article/663fb7a205c44dd2b03f48bdce71f689
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2
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands
Autor: J N, Champness, M S, Bennett, F, Wien, R, Visse, W C, Summers, P, Herdewijn, E, de Clerq, T, Ostrowski, R L, Jarvest, M R, Sanderson
Publikováno v: Proteins. 32(3)
Antiherpes therapies are principally targeted at viral thymidine kinases and utilize nucleoside analogs, the triphosphates of which are inhibitors of viral DNA polymerase or result in toxic effects when incorporated into DNA. The most frequently used
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::881a4ff63faff86e8db6a53ca36cfcf2
https://pubmed.ncbi.nlm.nih.gov/9715911
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6
Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir
Autor: D G, Brown, R, Visse, G, Sandhu, A, Davies, P J, Rizkallah, C, Melitz, W C, Summers, M R, Sanderson
Publikováno v: Nature structural biology. 2(10)
The crystal structures of thymidine kinase from herpes simplex virus type-1 complexed with its natural substrate deoxythymidine (dT) and complexed with the guanosine analogue Ganciclovir have been solved. Both structures are in the C222(1) crystal fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96324ab21b2861838501c791659f823c
https://pubmed.ncbi.nlm.nih.gov/7552712
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7
Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features
Autor: D G, Brown, M R, Sanderson, E, Garman, S, Neidle
Publikováno v: Journal of molecular biology. 226(2)
The AT-selective drug berenil has been co-crystallized with the dodecanucleotide sequence d(CGCAAATTTGCG)2. The crystal structure has been solved to a resolution of 2.0 A and an R factor of 18.3%, with the location of 65 water molecules. The drug is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::423bf7417049db049478aa3f1b9ab857
https://pubmed.ncbi.nlm.nih.gov/1640462
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9
Preparation of heavy-atom derivatives using site-directed mutagenesis. Introduction of cysteine residues into gamma delta resolvase
Autor: G F, Hatfull, M R, Sanderson, P S, Freemont, P R, Raccuia, N D, Grindley, T A, Steitz
Publikováno v: Journal of molecular biology. 208(4)
The ability to determine protein structures by X-ray crystallography is often thwarted by the difficulty of finding isomorphous heavy-atom derivatives. The crystal structure of the site-specific recombinase, resolvase, has been difficult to determine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc6f460f5777bd71ac75a5246456c5b6
https://pubmed.ncbi.nlm.nih.gov/2553982
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