Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M. R. Kasimov"'
Publikováno v:
Acta Naturae. 9:26-37
In our previous review, we described brain cholesterol metabolism in control conditions and in the case of some rare neurological pathologies linked to defects in the genes which are directly involved in the synthesis and/or traffic of cholesterol. H
Publikováno v:
Acta Naturae. 8:58-73
Cholesterol is an important constituent of cell membranes and plays a crucial role in the compartmentalization of the plasma membrane and signaling. Brain cholesterol accounts for a large proportion of the bodys total cholesterol, existing in two poo
Autor:
Guzel F. Zakyrjanova, Kamilla A. Mukhutdinova, Alexey M. Petrov, M. R. Kasimov, Milausha R. Gumerova
Publikováno v:
Neuropharmacology. 150
Elimination of brain cholesterol occurs in the form of 24S-hydroxycholesterol (24S-HCh) that may modulate physiological processes outside the brain. Here, using microelectrode recording of postsynaptic responses (end-plate potentials, EPPs) and fluor
Autor:
M. R. Kasimov, Kamilla A. Mukhutdinova, Alexey M. Petrov, A. R. Giniatullin, Guzel F. Zakyrjanova
Publikováno v:
Molecular and cellular neurosciences. 88
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the initial denervation of skeletal muscle and subsequent death of motor neurons. A dying-back pattern of ALS suggests a crucial role for neuromuscular junction dysf
Publikováno v:
Neuroscience and Behavioral Physiology. 44:1020-1030
Experiments on neuromuscular preparations from the frog Rana ridibunda assessed the effects of oxidation of membrane cholesterol on the presynaptic vesicle cycle. Application of cholesterol oxidase (1 activity unit) for 30 min oxidized about 0.007 mg
Publikováno v:
Neuropharmacology. 117
24S-hydroxycholesterol (24S-HC) is a brain-derived product of lipid metabolism present in the systemic circulation, where its level can change significantly in response to physiological and pathophysiological conditions. Here, using electrophysiologi
Publikováno v:
Biochimica et biophysica acta. 1861(7)
Cholesterol oxidation products frequently have a high biological activity. In the present study, we have used microelectrode recording of end plate currents and FM-based optical detection of synaptic vesicle exo-endocytosis to investigate the effects
Publikováno v:
Biochimica et biophysica acta. 1851(5)
We have investigated the effects of 5α-cholesten-3-one (5Ch3, 200 nM) on synaptic transmission in mouse diaphragm. 5Ch3 had no impact on the amplitude or frequency of miniature endplate currents (MEPCs, spontaneous secretion), but decreased the ampl
Publikováno v:
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 99(2)
In experiments on frog (Rana ridibunda) neuromuscular junction the influence of cholesterol oxidation on the presynaptic vesicular cycle was investigated. Application of cholesterol oxidase (1 u. a.) during 1/2 hour led to the oxidation of - 0.007 mg
Publikováno v:
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 95(7)
In experiments on the frog neuro-muscular preparations using electrophysiological (two electrode fixing of potential) and optical (fluorescent endocytic dye FM1-43) methods, the value of surface cholestertol for exo-endocytic cycle of synaptic vesicl