Zobrazeno 1 - 10
of 60
pro vyhledávání: '"M. R. Juchau"'
Publikováno v:
Alcoholism, clinical and experimental research. 24(9)
The human prenatal brain is very sensitive to the toxic effects of ethanol, but very little information is available concerning the conversion of ethanol to the highly cytotoxic metabolite, acetaldehyde, in that organ. Thus, experiments were designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2900e5f7d5e96f55d05a5ffd695b2e1
https://pubmed.ncbi.nlm.nih.gov/11003211
https://pubmed.ncbi.nlm.nih.gov/11003211
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
Cytochrome P4503A7 (CYP3A7) is the primary CYP isoform expressed in human fetal hepatic microsomes, and its potential role in human embryotoxicity has attracted considerable investigative attention. In this study, we investigated the 4-hydroxylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b2d9d7636f8f6cef1bbce815a2805f4
https://pubmed.ncbi.nlm.nih.gov/10950848
https://pubmed.ncbi.nlm.nih.gov/10950848
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(3)
Oxidative conversion of all-trans-retinol (t-ROH) to all-trans-retinal (t-RAL) is recognized as the rate-limiting step for biosynthesis of all-trans-retinoic acid from t-ROH in mammalian hepatic tissues. The purpose of this study was to investigate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51d2c09afa4f1946864f754a705c948f
https://pubmed.ncbi.nlm.nih.gov/10681376
https://pubmed.ncbi.nlm.nih.gov/10681376
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(11)
We investigated the catalysis of drug monooxygenation by human embryonic hepatic tissues at a very early stage of gestation (days 52-59). Imipramine was used as a model substrate and the metabolites generated were identified and quantified by electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6b2be00ccbe5a652cd5afb54c146d6c
https://pubmed.ncbi.nlm.nih.gov/10534316
https://pubmed.ncbi.nlm.nih.gov/10534316
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
Cytochrome P-450 2E1 (CYP2E1) is a readily inducible hemoprotein that catalyzes the oxidation of endogenous compounds and many low molecular weight xenobiotics. As the major component of the microsomal ethanol oxidizing system, it contributes signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e94a81d69b629de20c5d0aac7d4e6e3b
https://pubmed.ncbi.nlm.nih.gov/10336564
https://pubmed.ncbi.nlm.nih.gov/10336564
Autor:
H, Chen, M R, Juchau
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(3)
The purpose of this study was to investigate whether and to what extent the steric isomerization of retinoic acids in conceptal tissues can be attributed to enzymatic catalysis in addition to thiol-dependent, nonenzymatic catalysis. Conversions of 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b190a614000764d66f06138e57a35958
https://pubmed.ncbi.nlm.nih.gov/9492384
https://pubmed.ncbi.nlm.nih.gov/9492384
Autor:
M R, Juchau
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 49
In this review, an attempt has been made to summarize our current understanding of the mechanisms whereby certain chemicals cause birth defects. The chemicals selected for consideration were those that have been designated as established or recognize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fea9e870ed410ca37fe569d0ee85d5d0
https://pubmed.ncbi.nlm.nih.gov/9388384
https://pubmed.ncbi.nlm.nih.gov/9388384
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(12)
Investigations of catalysis of the O-dealkylation and O-debenzylation of phenoxazone (resorufin) ethers in human and rodent embryonic tissue homogenates indicated that, with few exceptions, each conceptal tissue investigated contained enzymes capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::638535456d58cb97bf9ae76bb21b1da8
https://pubmed.ncbi.nlm.nih.gov/8971143
https://pubmed.ncbi.nlm.nih.gov/8971143
Publikováno v:
Teratology. 53(1)
Previously, we reported that massive cell death was induced in the mesencephalic area of cultured rat embryos after embryos of gestational day 10.5 were intra-amniotically microinjected with sodium nitroprusside (SNP, 800 microM) and cultured for 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dfd79b37977d248035c5161df28eb20e
https://pubmed.ncbi.nlm.nih.gov/8928084
https://pubmed.ncbi.nlm.nih.gov/8928084
Autor:
J C, Kraft, M R, Juchau
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(10)
These investigations provide data pertaining to the metabolism and disposition of exogenous 9-cis-retinoic acid and all-trans-retinoic acid during neurulation in Xenopus embryos. Each isomer elicited malformations of the heart, eye, and brain, but ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7734dbfc8e5811da93cb440120f5b7f
https://pubmed.ncbi.nlm.nih.gov/8654193
https://pubmed.ncbi.nlm.nih.gov/8654193