Výsledky vyhledávání - "M. R. Jirousek"

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

Autor: Hidehiro Ishii, George L. King, H. Nawata, S E Bursell, F. Umeda, Makoto Kunisaki, M. R. Jirousek, Allen C. Clermont, L. M. Ballas

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 269:E239-E246

We have characterized effects of d-alpha-tocopherol (vitamin E) on activation of protein kinase C (PKC) and diacylglycerol (DAG) levels in retinal tissues of diabetic rats and correlated its effects to diabetes-induced changes in retinal hemodynamics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1c9dd8023e99c765be09483d38928b
https://doi.org/10.1152/ajpendo.1995.269.2.e239

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The Effect of 2- and 3-Lateral Substituents on the Acid Side of 4,4′-Disubstituted Phenylbenzoates and Phenylthiobenzoates on Mesomorphic Properties

Autor: M. R. Jirousek, Mary E. Neubert, K. Murray, S. Sabol Keast, F. Herlinger, J. Rambler, Y. Dixon-polverine, Katherine Leung

Publikováno v: Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 250:109-123

A variety of esters/thioesters of the type where A or B=F, Cl, Me; Z=O, S and Y=C10, OC10, COC9, CO2C9 and OCOC9 for Z=O and C5, C10, OC7, OC10 for Z=S and R=C8H17, C10H2, C12H25 were synthesized and their mesomorphic properties determined by hot-sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6acd6edf21436de948cfd0826b30d8a8
https://doi.org/10.1080/10587259408028197

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The Effect of Carbonyl Containing Terminal Chains on Mesomorphic Properties in 4,4′-Disubstituted Phenylbenzoates and Phenylthiobenzoates. 5. Phenylbenzoates Containing a (CH2)n02CR′ Group (n=1,2) on the Phenolic End

Autor: M. E. Neubert, C. M. Citano, M. C. Ezenyilimba, M. R. Jirousek, S. Sabol-keast, R. B. Sharma

Publikováno v: Molecular Crystals and Liquid Crystals. 206:103-116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fd9c6e32a3e2cb8ec20ffa7082aed90
https://doi.org/10.1080/00268949108037722

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The Effect of Carbonyl Containing Terminal Chains on Mesomorphic Properties in 4,4′- Disubstituted Phenylbenzoates and Phenylthiobenzoates. 4. Phenylbenzoates Containing A (CH2)nCO2R'Group (n = 0–2) on the Phenolic End

Autor: M. E. Neubert, K. Leung, M. R. Jirousek, M. C. Ezenyilimba, S. Sabol-keast, B. Ziemnicka-merchant, R. B. Sharma

Publikováno v: Molecular Crystals and Liquid Crystals. 197:21-41

The effect of a (CH2),CO2R' group on the mesomorphic properties of the esters where X= alkyl or alkoxy, Y=(CH2)nCO2R'(R'=C7 and C9) and n = 0–2 has been studied by synthesizing these esters and determining their mesomorphic properties by hot-stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1871192691b5cb17459d96eef8f1246c
https://doi.org/10.1080/00268949108029700

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Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors, and agents in development

Autor: P G, Goekjian, M R, Jirousek

Publikováno v: Current medicinal chemistry. 6(9)

Protein kinase C (PKC) is a family of enzymes that play a ubiquitous role in intracellular signal transduction. Our understanding of the precise role of PKC has evolved considerably as a result of improved methodology and a better understanding of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::efbb1f7caa6b981f4971d19f6ef4c9a2
https://pubmed.ncbi.nlm.nih.gov/10495357

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

Autor: M R, Jirousek, J R, Gillig, C M, Gonzalez, W F, Heath, J H, McDonald, D A, Neel, C J, Rito, U, Singh, L E, Stramm, A, Melikian-Badalian, M, Baevsky, L M, Ballas, S E, Hall, L L, Winneroski, M M, Faul

Publikováno v: Journal of medicinal chemistry. 39(14)

Protein kinase C (PKC) is a family of closely related serine and threonine kinases. Overactivation of some PKC isozymes has been postulated to occur in several diseases states, including diabetic complications. Selective inhibition of overactivated P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb5ac00681b250b31322178de9017690
https://pubmed.ncbi.nlm.nih.gov/8709095

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The Effect of Methyl Group Position in Branched Alkyl Chains on the Thiolic End of 4,4′-Disubstituted Thiophenylbenzoates on Mesomorphic Properties and Some Optically Active Analogs as New Ferroelectric Liquid Crystals

Autor: Mary E. Neubert, Ktherine Leung, Stanley J. Laskos, Matthew C. Ezenyilimba, M. R. Jirousek, Darrin Leonhardt, Brian A. Williams, Barbara Ziemnicka-merchant

Publikováno v: Molecular Crystals and Liquid Crystals Incorporating Nonlinear Optics. 166:181-230

The effect of the methyl group position in the branched alkyl chains of the thioesters where X = C8H7, RO, and C9CO2; m = 1–3 and n = 0–2 on mesomorphic properties is reported. These thioesters were prepared by esterification of the appropriate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae9bd8b1111cf7ee226278b5e0a23529
https://doi.org/10.1080/00268948908037150

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ChemInform Abstract: Robustadials. Part 4. Molecular Mechanics and Nuclear Magnetic Resonance Studies on Conformational and Configurational Equilibria: 3,4-Dihydrospiro(2H-1-benzopyran-2,2′-bicyclo(2.2.1)heptanes)

Autor: Samuel M. Mazza, Robert G. Salomon, M. R. Jirousek

Publikováno v: ChemInform. 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::344cfedc20b4b178a83d85189e48298a
https://doi.org/10.1002/chin.198906167

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