Variants associated with HHIP expression have sex-differential effects on lung function

Autor: Carl A. Melbourne, Caroline Hayward, Stefan Karrasch, Dirk Keidel, Katherine A. Fawcett, Susan M. Ring, Yohan Bossé, Carol A. Wang, Ben Michael Brumpton, Claudia Langenberg, Peter K. Joshi, Ke Hao, Igor Rudan, David J. Porteous, Don D. Sin, Raquel Granell, Blair H. Smith, Jian'an Luan, Kristian Hveem, Sarah E. Harris, Sandosh Padmanabhan, Archie Campbell, Sebastian May-Wilson, Veronique Vitart, Nicola Pirastu, Arnulf Langhammer, Craig E. Pennell, John M. Starr, Stefan Weiss, Karina Patasova, Nicholas J. Wareham, James F. Wilson, Deborah Jarvis, Tim D. Spector, Nick Shrine, David P. Strachan, Martin D. Tobin, Beate Stubbe, David M. Evans, Kirsi H. Pietiläinen, Mangino Massimo, Ian P. Hall, Graham L. Hall, Jaakko Kaprio, Ralf Ewert, Rachel E. Foong, Claudia Flexeder, Louise V. Wain, Ma'en Obeidat, Cristen J. Willer, Leo-Pekka Lyytikäinen, Olli T. Raitakari, John Henderson, Konstantin Strauch, Marta R Moksnes, Cosetta Minelli, Nicole Probst-Hensch, Pirro G. Hysi, Anna L. Guyatt, Henry Völzke, Thomas Meitinger, Peter D. Sly, Ozren Polasek, Anne Richmond, Mika Kähönen, Maarten van den Berge, Medea Imboden, Thibaud Boutin, Lucija Klaric, Laura Portas, Terho Lehtimäki, Ian J. Deary, Taina Rantanen, Catherine John, Teemu Palviainen

Publikováno v: Fawcett, K, Granell, R & Wain, L V 2021, ' Variants associated with HHIP expression have sex-differential effects on lung function ', Wellcome Open Research, vol. 5, pp. 1-20 . https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Wellcome open research, 5:111
Wellcome Open Research
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-Wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L P, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Berge, M V D, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-Hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sexdifferential effects on lung function ', Wellcome Open Research, vol. 5, pp. 1-20 . https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Wellcome Open Res. 5:111 (2021)
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Van Den Berge, M, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sex-differential effects on lung function ', Wellcome Open Research, vol. 5, pp. 111 . https://doi.org/10.12688/wellcomeopenres.15846.1

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312f5db945545c66e6f18c62faf6290c
https://research-information.bris.ac.uk/ws/files/287782046/3fa30dd5_3d84_4cd9_880c_57cb63dda7c6_15846_katherine_fawcett_v2.pdf

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