Výsledky vyhledávání - "M. R. Gastonguay"

Exposure-response modeling and clinical trial simulation of the effect of tolterodine on QT intervals in healthy volunteers

Autor: K R, Sweeney, M R, Gastonguay, L, Benincosa, C L, Cronenberger, P, Glue, B K, Malhotra

Publikováno v: Drug discoveriestherapeutics. 4(1)

The objective of this analysis was to explore exposure-response modeling of data from a thorough QT (TQT) study of tolterodine in CYP2D6 extensive (EMs) and poor metabolizers (PMs). Crossover treatments of the TQT study included the recommended (2 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::445f875866f5f91279b35acc33f3a5c9
https://pubmed.ncbi.nlm.nih.gov/22491151

Zobrazit plný text záznamu

Population pharmacokinetic modeling of pantoprazole in pediatric patients from birth to 16 years

Autor: W. Knebel, Xu Meng, C. Udata, B. Tammara, G. Comer, M. R. Gastonguay

Publikováno v: Journal of clinical pharmacology. 51(3)

The population pharmacokinetics of pantoprazole was characterized in pediatric patients from birth to 16 years using NONMEM and evaluated via bootstrap and predictive check. Data were described using a 2-compartment model with a typical parameterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec957b1dcb9ab0072c4e2a90ca5f518
https://pubmed.ncbi.nlm.nih.gov/20484619

Zobrazit plný text záznamu

Population pharmacokinetics of fluconazole in young infants

Autor: K C, Wade, D, Wu, D A, Kaufman, R M, Ward, D K, Benjamin, J E, Sullivan, N, Ramey, B, Jayaraman, K, Hoppu, P C, Adamson, M R, Gastonguay, J S, Barrett, Celeste, Crouse

Publikováno v: Antimicrobial agents and chemotherapy. 52(11)

Fluconazole is being increasingly used to prevent and treat invasive candidiasis in neonates, yet dosing is largely empirical due to the lack of adequate pharmacokinetic (PK) data. We performed a multicenter population PK study of fluconazole in 23-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43693ae5c8289a97fdd557c752ee319
https://pubmed.ncbi.nlm.nih.gov/18809946

Zobrazit plný text záznamu

Population pharmacokinetics and pharmacodynamics of sotalol in pediatric patients with supraventricular or ventricular tachyarrhythmia

Autor: J, Shi, T M, Ludden, A P, Melikian, M R, Gastonguay, P H, Hinderling

Publikováno v: Journal of pharmacokinetics and pharmacodynamics. 28(6)

To derive useful pharmacokinetic (PK) and pharmacodynamic (PD) information for guiding the clinical use of sotalol in pediatric patients with supraventricular (SVT) or ventricular tachyarrhythmia (VT).Two studies were conducted in-patients with SVT o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20c65ebdbe57b6e382f75fa4d836eb05
https://pubmed.ncbi.nlm.nih.gov/11999292

Zobrazit plný text záznamu

The use of multiple doses and pharmacodynamic system analysis to distinguish between dispositional delays and time-variant pharmacodynamics

Autor: M R, Gastonguay, S L, Schwartz

Publikováno v: Pharmaceutical research. 11(12)

Pharmacokinetic-pharmacodynamic modeling algorithms, in general, rely on hysteresis minimization techniques that assume time-invariant pharmacodynamics (constant biophase concentration-effect relationships). When time-variant pharmacodynamics are obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::439af0e7624dc8c33e5a1859b3c0f972
https://pubmed.ncbi.nlm.nih.gov/7899250

Zobrazit plný text záznamu

Physiologically based pharmacokinetic modelling of nicotine

Autor: M. R. Gastonguay, D. E. Robinson, N. J. Balter, S. L. Schwartz

Publikováno v: Nicotine and Related Alkaloids ISBN: 9789401049368

Pharmacokinetic models are used to describe or predict the time-dependent changes in drug concentration in blood and tissues, i.e., concentration × time (C × t) curves. There are two basic approaches to pharmacokinetic modelling. In the first, empi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52cf6c3818f6ff67aee4e078504d89d8
https://doi.org/10.1007/978-94-011-2110-1_12

Zobrazit plný text záznamu

Evaluation of the effect of residual error covariance for a parent-metabolite population pharmacokinetic model

Autor: B. E. Houk, Michael Amantea, M. R. Gastonguay

Publikováno v: Clinical Pharmacology & Therapeutics. 77:P91-P91

Background The residual error of parent and metabolite concentrations in pharmacokinetic (PK) samples can be correlated due to issues such as mislabeled timing, sample extraction, and misspecification, although it is not typically estimated in popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95a448c9226b219a352f32a3b113153b
https://doi.org/10.1016/j.clpt.2004.12.242

Zobrazit plný text záznamu

Effect of NONMEM minimization status and number of replicates on bootstrap parameter distributions for population pharmacokinetic models: A case study

Autor: A. El‐Tahtawy, M. R. Gastonguay

Publikováno v: Clinical Pharmacology & Therapeutics. 77:P2-P2

Aims Bootstrap (BS) parameter distributions are often used to characterize estimation uncertainty and determine confidence intervals (CI) for population pharmacokinetic (PPK) model parameters. These results are used to guide inferences about clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db6e759cb4ff6e5ac63a39438af9cb0e
https://doi.org/10.1016/j.clpt.2004.11.010

Zobrazit plný text záznamu

Population pharmacokinetic-pharmacodynamic modeling of efaproxiral in cancer patients receiving radiation therapy

Autor: R. Steffen, M. R. Gastonguay, J. Hackman, J. Venitz

Publikováno v: Clinical Pharmacology & Therapeutics. 77:P89-P89

Aims Efaproxiral (EFP), a synthetic allosteric modifier of hemoglobin (Hb), reduces O2-binding affinity in blood (p50) and is investigated as a radiation therapy sensitizer. The goal of this work was to describe the pharmacokinetics (PK) and pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22b0d2d6242ecb43f50a5213156fb668
https://doi.org/10.1016/j.clpt.2004.12.233

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání