Zobrazeno 1 - 10
of 110
pro vyhledávání: '"M. R. El-Maghrabi"'
Autor:
Meredith Hawkins, Preeti Kishore, Kehao Zhang, Sudha Koppaka, Sylvia Kehlenbrink, Roger Gutierrez-Juarez, M. R. El-Maghrabi, M. Hu
Publikováno v:
Diabetologia. 55(6)
Increased NEFA levels, characteristic of type 2 diabetes mellitus, contribute to skeletal muscle insulin resistance. While NEFA-induced insulin resistance was formerly attributed to decreased glycolysis, it is likely that glucose transport is the rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c76ef7ed0338e28c4741414eceb144
https://pubmed.ncbi.nlm.nih.gov/22460760
https://pubmed.ncbi.nlm.nih.gov/22460760
Publikováno v:
Biochemical and Biophysical Research Communications. 195:229-236
The role of Cys-138 in the catalysis of the skeletal muscle 6-phosphofructo-2-kinase reaction was investigated by mutating this residue to serine, glutamine and alanine, expressing the mutants in E. coli with a T7 RNA polymerase-based expression syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663f4b07911f131c63d9628a4caf1fca
https://doi.org/10.1006/bbrc.1993.2034
https://doi.org/10.1006/bbrc.1993.2034
Publikováno v:
Journal of Biological Chemistry. 268:17665-17668
A cDNA for an adipocyte membrane protein, implicated in the transport of long-chain fatty acids, was isolated by screening with a synthetic oligonucleotide derived from the amino terminal sequence of the protein. The 88-kDa adipocyte membrane protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca1428f927e302bdf17126b6c59164ff
https://doi.org/10.1016/s0021-9258(17)46753-6
https://doi.org/10.1016/s0021-9258(17)46753-6
Publikováno v:
Journal of Biological Chemistry. 268:14056-14064
The role of the NH2-terminal region of the liver and skeletal muscle 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases was investigated, as well that of a mutant of the liver isoform lacking the first 22 amino acids, by the overexpression of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9caffde4fe04b193b63bf2ca4f8e8752
https://doi.org/10.1016/s0021-9258(19)85208-0
https://doi.org/10.1016/s0021-9258(19)85208-0
Autor:
D K Granner, R Hall, A. M. Vargas, Carme Espinet, A.J. Lange, Richard J. Miksicek, M R el-Maghrabi, Simon J. Pilkis
Publikováno v:
Journal of Biological Chemistry. 267:15673-15680
At least two genes encode isoenzymes of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Alternative splicing of one of these genes generates a skeletal muscle-specific transcript from an upstream promoter and a liver-specific transcript fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a42c291ab63a1ea6ff3c9569504f00
https://doi.org/10.1016/s0021-9258(19)49588-4
https://doi.org/10.1016/s0021-9258(19)49588-4
Autor:
José Carreras, Fernando Climent, P Puigdomenech, L de Lecea, Xavier Graña, Jesús M. Ureña, M R el-Maghrabi, S. J. Pilkis, C Caellas
Publikováno v:
Journal of Biological Chemistry. 267:12797-12803
The primary sequence of maize 2,3-bisphosphoglycerate-independent phosphoglycerate mutase was deduced from cDNAs isolated from maize cDNA libraries by screening with specific antibodies to the cofactor-independent enzyme and from a maize genomic clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a73931e7c27119bb963d87a3ab79fd
https://doi.org/10.1016/s0021-9258(18)42346-0
https://doi.org/10.1016/s0021-9258(18)42346-0
Publikováno v:
Journal of Biological Chemistry. 267:6526-6530
Lysine 274 is conserved in all known fructose-1,6-bisphosphatase sequences. It has been implicated in substrate binding and/or catalysis on the basis of reactivity with pyridoxal phosphate as well as by x-ray crystallographic analysis. Lys274 of rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2488011f7522738b3261c0c68d56500
https://doi.org/10.1016/s0021-9258(19)50459-8
https://doi.org/10.1016/s0021-9258(19)50459-8
Publikováno v:
Journal of Biological Chemistry. 267:4416-4423
The mechanism by which cAMP-dependent protein kinase-catalyzed phosphorylation modulates the activities of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase was examined after site-specific mutation of the cAMP-dependent phosphorylation site (Ser3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::252cfc1f0150174a37714644300a472c
https://doi.org/10.1016/s0021-9258(18)42851-7
https://doi.org/10.1016/s0021-9258(18)42851-7
Publikováno v:
Journal of Biological Chemistry. 266:2115-2120
The gene encoding rat fructose-1,6-bisphosphatase was isolated from a rat genomic Charon 4A library by screening with a cDNA to the rat liver enzyme. Southern blotting of rat genomic DNA showed that there is a single copy of the fructose-1,6-bisphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::102e649727182337c47fcb45d66cd87b
https://doi.org/10.1016/s0021-9258(18)52217-1
https://doi.org/10.1016/s0021-9258(18)52217-1
Autor:
J Pilkis, M R el-Maghrabi, A.J. Lange, I. J. Kurland, Liang Zhong Xu, Kai Lin, Simon J. Pilkis
Publikováno v:
Protein Expression and Purification. 1:169-176
A number of mammalian enzymes have been expressed in Escherichia coli using the T7 RNA polymerase system, but the production of large amounts of these proteins has been limited by the low percentage of active enzyme that is found in the soluble fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535235ac57fe04e4dc368d1f0a8d705c
https://doi.org/10.1016/1046-5928(90)90012-n
https://doi.org/10.1016/1046-5928(90)90012-n